Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

(2019) Xiaoli Huang et al.   Cell and Bioscience

Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

(2019) Anja Pfalzgraff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation

(2018) José Carlos Santos et al.   EMBO JOURNAL

Toll Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide from Bacterial Outer Membrane Vesicles

(2018) Lan Gu et al.   SHOCK

Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

(2018) Shouwen Chen et al.   PLoS Pathogens

HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis

(2018) Ho Min Kim et al.   IMMUNITY

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

High-Fat Diet During the Perinatal Period Induces Loss of Myenteric Nitrergic Neurons and Increases Enteric Glial Density, Prior to the Development of Obesity

(2018) Caitlin A. McMenamin et al.   NEUROSCIENCE

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

(2018) Shigetoshi Yokoyama et al.   eLife

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling

(2017) François Reichardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon

(2017) I. Kaji et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

(2017) Ryan Finethy et al.   mBio

Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon

(2017) Conor J. McCann et al.   Nature Communications

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

(2017) Carolina Pellegrini et al.   Frontiers in Immunology

High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon

(2016) Yogesh Bhattarai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Upregulation of bile acid receptor TGR5 and nNOS in gastric myenteric plexus is responsible for delayed gastric emptying after chronic high-fat feeding in rats

(2015) Hui Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice

(2015) Angelica Soares et al.   BMC GASTROENTEROLOGY

Prolonged high fat diet ingestion, obesity, and type 2 diabetes symptoms correlate with phenotypic plasticity in myenteric neurons and nerve damage in the mouse duodenum

(2015) Chloe M. Stenkamp-Strahm et al.   CELL AND TISSUE RESEARCH

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

(2015) Mirza Saqib Baig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

(2015) Yan Geng et al.   JOURNAL OF HEPATOLOGY

Caspase target drives pyroptosis

(2015) Petr Broz   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

(2014) V Derangère et al.   CELL DEATH AND DIFFERENTIATION

High-Fat Diet Promotes Neuronal Loss in the Myenteric Plexus of the Large Intestine in Mice

(2014) Evandro José Beraldi et al.   DIGESTIVE DISEASES AND SCIENCES

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet

(2014) L. R. Rivera et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

(2014) Christopher R. Lupfer et al.   PLoS Pathogens

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

High-fat diet ingestion correlates with neuropathy in the duodenum myenteric plexus of obese mice with symptoms of type 2 diabetes

(2013) Chloe M. Stenkamp-Strahm et al.   CELL AND TISSUE RESEARCH

MicroRNA 375 Mediates Palmitate-Induced Enteric Neuronal Damage and High-Fat Diet-Induced Delayed Intestinal Transit in Mice

(2013) Behtash Ghazi Nezami et al.   GASTROENTEROLOGY

Loss of TLR2 Worsens Spontaneous Colitis in MDR1A Deficiency through Commensally Induced Pyroptosis

(2013) B. Ey et al.   JOURNAL OF IMMUNOLOGY

Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice

(2013) François Reichardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enteric Neuropathy Can Be Induced by High Fat Diet In Vivo and Palmitic Acid Exposure In Vitro

(2013) Ulrikke Voss et al.   PLoS One

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Comparison of Effects of Long-Term Low-Fat vs High-Fat Diets on Blood Lipid Levels in Overweight or Obese Patients: A Systematic Review and Meta-Analysis

(2013) Lukas Schwingshackl et al.   Journal of the Academy of Nutrition and Dietetics

The importance of interstitial cells of cajal in the gastrointestinal tract

(2013) OthmanA Al-Shboul   Saudi Journal of Gastroenterology

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

(2013) Tricia H. Smith et al.   Jove-Journal of Visualized Experiments

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis

(2012) Sanna Nyström et al.   EMBO JOURNAL

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway

(2012) J. D. Schilling et al.   JOURNAL OF IMMUNOLOGY

nNOS mediated mitochondrial injury in LPS stimulated oligodendrocytes

(2012) S.-Y. Yao et al.   MITOCHONDRION

Potential mechanisms for the emerging link between obesity and increased intestinal permeability

(2012) Tatiana F.S. Teixeira et al.   NUTRITION RESEARCH

Deleterious effects of intestinal ischemia/reperfusion injury in the mouse enteric nervous system are associated with protein nitrosylation

(2011) Leni Rose Rivera et al.   CELL AND TISSUE RESEARCH

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Constipation and Colonic Transit Times in Children With Morbid Obesity

(2011) Olga H vd Baan-Slootweg et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor

(2011) Charlotte Baudry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Breast milk contains relevant neurotrophic factors and cytokines for enteric nervous system development

(2011) Michael Fichter et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Selective responses of myenteric neurons to oxidative stress and diabetic stimuli

(2011) E. Voukali et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Characterization of Fetal and Postnatal Enteric Neuronal Cell Lines With Improvement in Intestinal Neural Function

(2008) Mallappa Anitha et al.   GASTROENTEROLOGY