Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Recent Advances in Lipopolysaccharide Recognition Systems

(2020) Lalita Mazgaeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TMEM173 Drives Lethal Coagulation in Sepsis

(2020) Hui Zhang et al.   Cell Host & Microbe

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction

(2019) Jinsu An et al.   Scientific Reports

E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation

(2019) Qingjun Liu et al.   CELL DEATH AND DIFFERENTIATION

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis

(2019) Ruochan Chen et al.   Science Advances

ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages

(2019) Chen-Ying Zeng et al.   APOPTOSIS

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

(2019) Sacha Benaoudia et al.   EMBO REPORTS

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

Mechanism of membrane pore formation by human gasdermin‐D

(2018) Estefania Mulvihill et al.   EMBO JOURNAL

LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation

(2018) José Carlos Santos et al.   EMBO JOURNAL

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes

(2018) Natalie J Bitto et al.   IMMUNOLOGY AND CELL BIOLOGY

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide from Bacterial Outer Membrane Vesicles

(2018) Lan Gu et al.   SHOCK

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

(2018) Lan H. Chu et al.   Nature Communications

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

(2018) Brice Lagrange et al.   Nature Communications

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

(2018) Beiyun C. Liu et al.   Cell Reports

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From Inflammasome to Exosome—Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

(2018) Wojciech Cypryk et al.   Frontiers in Immunology

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

(2017) Ryan Finethy et al.   mBio

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages

(2016) Elina Välimäki et al.   JOURNAL OF IMMUNOLOGY

Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection

(2016) Wojciech Cypryk et al.   JOURNAL OF PROTEOME RESEARCH

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

(2014) T. Ohman et al.   JOURNAL OF IMMUNOLOGY

Quantitative Proteomics of Extracellular Vesicles Released from Human Monocyte-Derived Macrophages upon β-Glucan Stimulation

(2014) Wojciech Cypryk et al.   JOURNAL OF PROTEOME RESEARCH

Inefficient star formation in extremely metal poor galaxies

(2014) Yong Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY