An updated view on the structure and function of PYRIN domains

Regulated Cell Death: Signaling and Mechanisms

(2014) Avi Ashkenazi et al.   Annual Review of Cell and Developmental Biology

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4

(2014) K A Porter et al.   GENES AND IMMUNITY

A Critical Role for Human Caspase-4 in Endotoxin Sensitivity

(2014) Y. Kajiwara et al.   JOURNAL OF IMMUNOLOGY

cASCading specks

(2014) Lori Broderick et al.   NATURE IMMUNOLOGY

The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

(2014) Sonal Khare et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Crystal Structure of a Complex of NOD1 CARD and Ubiquitin

(2014) Aaron M. Ver Heul et al.   PLoS One

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions

(2014) Clarissa Eibl et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and preliminary X-ray crystallographic studies of cPOP1

(2013) Kyung Hoon Do et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

(2013) Tengchuan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Regulates Caspase Recruitment Domain-mediated Signaling by Nucleotide-binding Oligomerization Domain-containing Proteins NOD1 and NOD2

(2013) Aaron M. Ver Heul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD

(2013) Tae-ho Jang et al.   PLoS One

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy

(2013) S. R. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Structural and Functional Analysis of the NLRP4 Pyrin Domain

(2012) Clarissa Eibl et al.   BIOCHEMISTRY

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Structural Features of Caspase-Activating Complexes

(2012) Hyun Ho Park   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

(2012) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Redox control of NLRP3 inflammasome activation in health and disease

(2012) Anna Rubartelli   JOURNAL OF LEUKOCYTE BIOLOGY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

Structural analyses of death domains and their interactions

(2011) Hyun Ho Park   APOPTOSIS

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Uncoupling of Pyrin-only Protein 2 (POP2)-mediated Dual Regulation of NF-κB and the Inflammasome

(2011) Maninjay K. Atianand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

(2011) Ju Young Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

(2011) N. Jounai et al.   JOURNAL OF IMMUNOLOGY

The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights

(2011) Anderson S. Pinheiro et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The death-fold superfamily of homotypic interaction motifs

(2011) Kristof Kersse et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Three-dimensional Structure of the NLRP7 Pyrin Domain

(2010) Anderson S. Pinheiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

(2010) Nicole B Bryan et al.   Journal of Inflammation-London

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation

(2009) J. Michael Elliott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Mapping of POP1-binding Site on Pyrin Domain of ASC

(2008) Thiagarajan Srimathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY