Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

(2015) Neil J. Grimsey et al.   JOURNAL OF CELL BIOLOGY

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection

(2015) Kelly M. Storek et al.   JOURNAL OF IMMUNOLOGY

Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model

(2015) Z. Shao et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Olfactomedin 4 Serves as a Marker for Disease Severity in Pediatric Respiratory Syncytial Virus (RSV) Infection

(2015) H. K. Brand et al.   PLoS One

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

(2015) Timothy E. Sweeney et al.   Science Translational Medicine

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Patterns of Gene Expression in Peripheral Blood Mononuclear Cells and Outcomes from Patients with Sepsis Secondary to Community Acquired Pneumonia

(2014) Patricia Severino et al.   PLoS One

Host Responses to Sepsis Vary in Different Low-Lethality Murine Models

(2014) Lori F. Gentile et al.   PLoS One

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

(2014) Christopher R. Lupfer et al.   PLoS Pathogens

The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria

(2013) J.Y. Zhang et al.   BRITISH JOURNAL OF DERMATOLOGY

A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

(2013) Purvesh Khatri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Severe Sepsis and Septic Shock

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1

(2012) Daniel J.-F. Chinnapen et al.   DEVELOPMENTAL CELL

Type I IFN Receptor and the B Cell Antigen Receptor Regulate TLR7 Responses via Distinct Molecular Mechanisms

(2012) J. S. Poovassery et al.   JOURNAL OF IMMUNOLOGY

Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection

(2012) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

A Single Native Ganglioside GM1-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

(2012) M. G. Jobling et al.   mBio

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes

(2011) Jeffrey Maranto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Characteristics of Clinical Sepsis Reflected in a Reliable and Reproducible Rodent Sepsis Model

(2011) Falk A. Gonnert et al.   JOURNAL OF SURGICAL RESEARCH

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic and cell intrinsic roles of Gq  signaling in the regulation of innate immunity, oxidative stress, and longevity in Caenorhabditis elegans

(2010) T. Kawli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shock

(2009) Duane Funk et al.   Current Opinion in Critical Care

Site-Specific Carboxypeptidase B1 Tyrosine Nitration and Pathophysiological Implications following Its Physical Association with Nitric Oxide Synthase-3 in Experimental Sepsis

(2009) S. Chatterjee et al.   JOURNAL OF IMMUNOLOGY

Enhanced Monocyte Response and Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections

(2009) Monica I. Ardura et al.   PLoS One

Functions of the complement components C3 and C5 during sepsis

(2008) Michael A. Flierl et al.   FASEB JOURNAL

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM1 Molecules

(2008) A. A. Wolf et al.   INFECTION AND IMMUNITY

Complexity of complement activation in sepsis

(2008) Maciej M. Markiewski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)

(2008) Lawrence L.K. Leung et al.   MOLECULAR IMMUNOLOGY

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES