HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression

Simvastatin Inhibits Endotoxin-Induced Apoptosis in Liver and Spleen Through Up-Regulation of Survivin/NF-κB/p65 Expression

(2019) Lana Nežić et al.   Frontiers in Pharmacology

Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

(2019) Anja Pfalzgraff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ

(2019) Xiaojin Zhang et al.   CELL DEATH AND DIFFERENTIATION

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke

(2018) Yu Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Crystal structure of the mammalian lipopolysaccharide detoxifier

(2018) Alexei Gorelik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization

(2018) Qiuyue Kong et al.   DIABETES

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury

(2017) Benkun Zou et al.   PLoS Pathogens

Pyroptosis as a Regulated Form of Necrosis

(2016) Jun-ichi Abe et al.   CIRCULATION RESEARCH

Induction of heat shock protein 27 by bicyclol attenuates d -galactosamine/lipopolysaccharide-induced liver injury

(2016) Hui-Juan Dai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

(2016) Brooke A. Napier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein

(2016) Zhili Yao et al.   JOURNAL OF IMMUNOLOGY

Liver — guardian, modifier and target of sepsis

(2016) Pavel Strnad et al.   Nature Reviews Gastroenterology & Hepatology

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

(2015) Shuhong Guo et al.   JOURNAL OF IMMUNOLOGY

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

(2015) Melissa C. Wren et al.   Molecular Neurodegeneration

Hepatic Scavenger Receptor BI Protects Against Polymicrobial-induced Sepsis through Promoting LPS Clearance in Mice

(2014) Ling Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous Heat Shock Cognate Protein 70 Pretreatment Attenuates Cardiac and Hepatic Dysfunction With Associated Anti-inflammatory Responses in Experimental Septic Shock

(2014) Jong-Hau Hsu et al.   SHOCK

Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity

(2013) B. M. Janelsins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes

(2012) Baomei Shao et al.   Innate Immunity

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

(2012) Peter Recknagel et al.   PLOS MEDICINE

Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice

(2011) Aditya Ambade et al.   HEPATOLOGY

Host Inactivation of Bacterial Lipopolysaccharide Prevents Prolonged Tolerance Following Gram-Negative Bacterial Infection

(2008) Mingfang Lu et al.   Cell Host & Microbe

β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes

(2008) Melanie J. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY