Interfering with pH regulation in tumours as a therapeutic strategy

An intramolecular transport metabolon: fusion of carbonic anhydrase II to the COOH terminus of the Cl−/HCO3− exchanger, AE1

(2011) Daniel Sowah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII

(2011) Christina Battke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model

(2011) Kathrin Schwager et al.   HUMAN REPRODUCTION

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

(2011) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Tenascins and the Importance of Adhesion Modulation

(2011) R. Chiquet-Ehrismann et al.   Cold Spring Harbor Perspectives in Biology

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies

(2010) Michael Fiechter et al.   ATHEROSCLEROSIS

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

(2010) William Harley et al.   BRAIN RESEARCH

Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII

(2010) O. Guler et al.   CURRENT MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibition/Activation: Trip of a Scientist Around the World in the Search of Novel Chemotypes and Drug Targets

(2010) Claudiu T. Supuran   CURRENT PHARMACEUTICAL DESIGN

Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy

(2010) Alexander B. Stillebroer et al.   EUROPEAN UROLOGY

A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies

(2010) Alexander Berndt et al.   HISTOCHEMISTRY AND CELL BIOLOGY

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy

(2010) Enrico P Spugnini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism

(2010) S. Fais   JOURNAL OF INTERNAL MEDICINE

Proton dynamics in cancer

(2010) Veronica Huber et al.   Journal of Translational Medicine

Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors

(2010) Seppo Parkkila et al.   MODERN PATHOLOGY

A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients

(2010) M. Siebels et al.   WORLD JOURNAL OF UROLOGY

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian α-carbonic anhydrase isoforms

(2009) Seppo Parkkila et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

(2009) Julia K.J. Ahlskog et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients

(2009) S. Sauer et al.   BLOOD

In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy

(2009) C. Schliemann et al.   BLOOD

A Proteomic Approach for the Identification of Vascular Markers of Liver Metastasis

(2009) B. Borgia et al.   CANCER RESEARCH

V-ATPase inhibitors and implication in cancer treatment

(2009) Mario Pérez-Sayáns et al.   CANCER TREATMENT REVIEWS

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

(2009) Peter Ebbesen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma

(2009) Christoph Schliemann et al.   LEUKEMIA RESEARCH

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

(2009) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

(2009) Kathrin Schwager et al.   ARTHRITIS RESEARCH & THERAPY

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2diffusion

(2008) Pawel Swietach et al.   BJU INTERNATIONAL

Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2

(2008) C. Schliemann et al.   BLOOD

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non-Small Cell Lung Cancer

(2008) A. Soltermann et al.   CLINICAL CANCER RESEARCH

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

(2008) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

(2008) Maamar Stiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: Two human antibodies investigated in clinical trials in patients with cancer

(2008) Marta Pedretti et al.   LUNG CANCER

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

(2008) Jennifer S. Fang et al.   SEMINARS IN CANCER BIOLOGY