Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

(2017) Alessio Nocentini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

(2017) Xianfeng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study

(2017) Alessio Nocentini et al.   ACS Medicinal Chemistry Letters

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

(2017) Ebere Sonoiki et al.   Nature Communications

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

(2016) Vincenzo Alterio et al.   CHEMICAL COMMUNICATIONS

Recent Developments in the Chemistry and Biological Applications of Benzoxaboroles

(2015) Agnieszka Adamczyk-Woźniak et al.   CHEMICAL REVIEWS

Bacterial, fungal and protozoan carbonic anhydrases as drug targets

(2015) Clemente Capasso et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

(2014) Karen O'Dwyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigation of fungicidal activity of 3-piperazine-bis(benzoxaborole) and its boronic acid analogue

(2014) Dorota Wieczorek et al.   APPLIED ORGANOMETALLIC CHEMISTRY

The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments

(2014) C. Tony Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ComparativeIn VitroActivities of GSK2251052, a Novel Boron-Containing Leucyl-tRNA Synthetase Inhibitor, against 916 Anaerobic Organisms

(2013) Ellie J. C. Goldstein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

(2013) Vincent Hernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potency and Spectrum of Activity of AN3365, a Novel Boron-Containing Protein Synthesis Inhibitor, Tested against Clinical Isolates of Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli

(2013) Rodrigo E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

(2013) Tsutomu Akama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

(2013) Tsutomu Akama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles

(2013) SS Printsevskaya et al.   Future Medicinal Chemistry

Boron chemicals in diagnosis and therapeutics

(2013) Bhaskar C Das et al.   Future Medicinal Chemistry

The synthesis of benzoxaboroles and their applications in medicinal chemistry

(2013) Jiong Zhang et al.   Science China-Chemistry

Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase

(2013) Qing-Hua Hu et al.   Scientific Reports

Boron Containing Compounds as Protease Inhibitors

(2012) Reem Smoum et al.   CHEMICAL REVIEWS

Disclosing the Structure/Activity Correlation in Trivalent Boron-Containing Compounds: A Tendency Map

(2012) Jessica Cid et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antiparasitic agents: new drugs on the horizon

(2012) Pascal Mäser et al.   CURRENT OPINION IN PHARMACOLOGY

Molecule of the Month

(2012) Robert T. Jacobs et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Boron as a platform for new drug design

(2012) Laura Ciani et al.   Expert Opinion on Drug Discovery

New therapeutic options for onychomycosis

(2012) Aditya K Gupta et al.   EXPERT OPINION ON PHARMACOTHERAPY

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

(2012) Yvonne R. Freund et al.   FEBS LETTERS

Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents

(2012) Zhitao Qiao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

(2012) Andrés Palencia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recent Progress in the Synthesis of Antimalarial Agents

(2012) Yong-Kang Zhang et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Neglected tropical diseases: survey and geometry of randomised evidence

(2012) S. Kappagoda et al.   BMJ-British Medical Journal

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties

(2011) Xianfeng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors

(2011) Yi Xia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

(2011) Yong-Kang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Boron-containing inhibitors of synthetases

(2011) Stephen J. Baker et al.   CHEMICAL SOCIETY REVIEWS

Boron-based drugs as antiprotozoals

(2011) Robert T. Jacobs et al.   CURRENT OPINION IN INFECTIOUS DISEASES

State of the Art in African Trypanosome Drug Discovery

(2011) Robert T. Jacobs et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

(2011) Robert T Jacobs et al.   Future Medicinal Chemistry

Design, Synthesis, and Structure−Activity Relationship ofTrypanosoma bruceiLeucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

(2011) Dazhong Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel benzoxaborole-containing phenylalanine analogues

(2011) Xianfeng Li et al.   TETRAHEDRON LETTERS

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application

(2010) Yong-Kang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease

(2010) Xianfeng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

(2010) Charles Z. Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents

(2010) Yong-Kang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

REVIEW ARTICLE: Toenail onychomycosis: an important global disease burden

(2010) J. Thomas et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications

(2010) Paul C. Trippier et al.   MedChemComm

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

(2009) Tsutomu Akama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids asd,d-Carboxypeptidase R39 Inhibitors

(2009) Steven R. Inglis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Benzoboroxoles as Efficient Glycopyranoside-Binding Agents in Physiological Conditions: Structure and Selectivity of Complex Formation

(2008) Marie Bérubé et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY