Structure-based drug discovery of carbonic anhydrase inhibitors

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

(2011) Shyamasri Biswas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

(2011) Francesco Mincione et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium

(2011) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

(2011) Simona Maria Monti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Structure-Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

(2011) L. W. Lawrence Woo et al.   ChemMedChem

Novel therapies for glaucoma: a patent review 2007 – 2011

(2011) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology

(2011) Francesca Fabrizi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Characterization and inhibition studies of an α-carbonic anhydrase from the endangered sturgeon speciesAcipenser gueldenstaedti

(2011) Sevgi Kolayli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and XIV

(2011) Naama Hen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Rescue of Enzymes: Proton Transfer in Mutants of Human Carbonic Anhydrase II

(2011) C. Mark Maupin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Bacterial Carbonic Anhydrases as Drug Targets: Toward Novel Antibiotics?

(2011) Claudiu T. Supuran   Frontiers in Pharmacology

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

(2010) Jason Wagner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition studies of a β-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides

(2010) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

(2010) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides

(2010) Fabio Pacchiano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

Brucella Carbonic Anhydrases: New Targets for Designing Anti-Infective Agents

(2010) Jean-Yves Winum et al.   CURRENT PHARMACEUTICAL DESIGN

The β-Carbonic Anhydrases from Mycobacterium tuberculosis as Drug Targets

(2010) Isao Nishimoria et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides

(2010) Lina Baranauskienė et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

(2009) Rebecca M. Steele et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

(2009) Julia K.J. Ahlskog et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active β-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

(2009) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme

(2009) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

(2009) Peter Ebbesen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors. Cloning, Characterization, and Inhibition Studies of a New β-Carbonic Anhydrase fromMycobacterium tuberculosis

(2009) Isao Nishimori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Cloning, Characterization, and Inhibition Studies of the Rv1284 β-Carbonic Anhydrase fromMycobacterium tuberculosiswith Sulfonamides and a Sulfamate

(2009) Tomoko Minakuchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial β-Carbonic Anhydrases Rv1284 and Rv3273

(2009) Özlen Güzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

(2009) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Recent Advances in Research on the Most Novel Carbonic Anhydrases,CA XIII and XV

(2008) S. Parkkila et al.   CURRENT PHARMACEUTICAL DESIGN

The α and β Classes Carbonic Anhydrases from Helicobacter pylori as Novel Drug Targets

(2008) Hiroaki Takeuchi et al.   CURRENT PHARMACEUTICAL DESIGN

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

(2008) John F. Domsic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

(2008) Yan Xu et al.   NATURE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

(2008) Anna Di Fiore et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS