The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

Tumor pH and metastasis: a malignant process beyond hypoxia

(2019) Oliver Thews et al.   CANCER AND METASTASIS REVIEWS

Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding

(2019) Sofia Gkountela et al.   CELL

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

(2019) Mariantonia Logozzi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

(2019) Nazanin Rohani et al.   CANCER RESEARCH

What is pH regulation, and why do cancer cells need it?

(2019) Pawel Swietach   CANCER AND METASTASIS REVIEWS

Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells

(2019) Anne Riemann et al.   NEOPLASIA

Positron Emission Tomography/Computed Tomography with 89 Zr-girentuximab Can Aid in Diagnostic Dilemmas of Clear Cell Renal Cell Carcinoma Suspicion

(2018) Marlène C.H. Hekman et al.   EUROPEAN UROLOGY

HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters

(2018) Norio Suzuki et al.   EXPERIMENTAL CELL RESEARCH

The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells

(2018) Samantha Ames et al.   Oncotarget

Cancer radiotheranostics targeting carbonic anhydrase-IX with 111In- and 90Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy

(2018) Shimpei Iikuni et al.   Theranostics

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

(2018) Shen-Han Lee et al.   BRITISH JOURNAL OF CANCER

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

(2017) Sofia Avnet et al.   INTERNATIONAL JOURNAL OF CANCER

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion

(2017) M Swayampakula et al.   ONCOGENE

Tuning Collective Cell Migration by Cell–Cell Junction Regulation

(2017) Peter Friedl et al.   Cold Spring Harbor Perspectives in Biology

Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity

(2017) Helena C. Christianson et al.   Oncotarget

The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

(2016) Brian P. Mahon et al.   BIOCHEMISTRY

Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers

(2016) Peng-Cheng Lv et al.   BIOCONJUGATE CHEMISTRY

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy

(2016) Ivana Vidlickova et al.   BMC CANCER

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells

(2016) E. Bourseau-Guilmain et al.   Nature Communications

Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts

(2016) Delphine Tamara Marie-Egyptienne et al.   Oncotarget

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

(2016) Scott K. Parks et al.   Oncotarget

Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis

(2016) Simon J. A. van Kuijk et al.   Frontiers in Oncology

Metabolism and Its Sequelae in Cancer Evolution and Therapy

(2015) Robert J. Gillies et al.   CANCER JOURNAL

Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production

(2015) S. C. Chafe et al.   CANCER RESEARCH

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

[18F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models

(2015) Sarah G. J. A. Peeters et al.   MOLECULAR IMAGING AND BIOLOGY

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

(2015) Jaromir Pastorek et al.   SEMINARS IN CANCER BIOLOGY

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

(2015) Ioanna Ledaki et al.   Oncotarget

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

(2015) Somayeh Jamali et al.   Scientific Reports

Expression Pattern of Carbonic Anhydrase IX in Medullary Thyroid Carcinoma Supports a Role for RET-Mediated Activation of the HIF Pathway

(2014) Martina Takacova et al.   AMERICAN JOURNAL OF PATHOLOGY

Monoclonal antibody G250 targeting CA IX: Binding specificity, internalization and therapeutic effects in a non-renal cancer model

(2014) MIRIAM ZATOVICOVA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Site-specific metabolic phenotypes in metastatic breast cancer

(2014) Hye Min Kim et al.   Journal of Translational Medicine

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

(2013) Tania Fiaschi et al.   CELL CYCLE

Application of Monoclonal Antibody G250 Recognizing Carbonic Anhydrase IX in Renal Cell Carcinoma

(2013) Jeannette Oosterwijk-Wakka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

(2013) PETER RADVAK et al.   ONCOLOGY REPORTS

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

(2013) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration

(2013) Lucia Csaderova et al.   Frontiers in Physiology

Binding of carbonic anhydrase IX to extracellular loop 4 of the NBCe1 Na+/HCO3− cotransporter enhances NBCe1-mediated HCO3− influx in the rat heart

(2012) Alejandro Orlowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

(2012) A. McIntyre et al.   CLINICAL CANCER RESEARCH

Dendritic cell reprogramming by the hypoxic environment

(2012) Maria Carla Bosco et al.   IMMUNOBIOLOGY

Reproducibility and biological basis of in vivoT2* magnetic resonance imaging of liver metastasis of colorectal cancer

(2012) E. G. W. ter Voert et al.   MAGNETIC RESONANCE IN MEDICINE

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

(2011) Saskia E Rademakers et al.   BMC CANCER

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

(2011) P. Ditte et al.   CANCER RESEARCH

Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes

(2011) N. K. Tafreshi et al.   CLINICAL CANCER RESEARCH

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX

(2011) Margarita T. Murri-Plesko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High Stromal Carbonic Anhydrase IX Expression Is Associated With Decreased Survival in p16-Negative Head-and-Neck Tumors

(2011) Nigel Brockton et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

(2011) Eliska Svastova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Mechanism and Efficacy of the Antibody-Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9

(2011) H. M. Petrul et al.   MOLECULAR CANCER THERAPEUTICS

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Measuring carbonic anhydrase IX as a hypoxia biomarker: differences in concentrations in serum and plasma using a commercial enzyme-linked immunosorbent assay due to influences of metal ions

(2011) T. C. Wind et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic Domain

(2010) M. Zatovicova et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy

(2010) Alexander B. Stillebroer et al.   EUROPEAN UROLOGY

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antibody-specific detection of CAIX in breast and prostate cancers

(2009) Ying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian α-carbonic anhydrase isoforms

(2009) Seppo Parkkila et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

(2009) J K J Ahlskog et al.   BRITISH JOURNAL OF CANCER

Protons make tumor cells move like clockwork

(2009) Christian Stock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant

(2008) Y. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

(2008) Jennifer S. Fang et al.   SEMINARS IN CANCER BIOLOGY