Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

Published 2018 View Full Article

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Title
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents
Authors
Keywords
Anticancer activity, Selective hCA IX and XII inhibitors, SLC-0111 hybrids, Tail approach, VEGFR-2 inhibitors
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 162, Issue -, Pages 147-160
Publisher
Elsevier BV
Online
2018-11-03
DOI
10.1016/j.ejmech.2018.10.068

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