Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation

(2016) Silvia Peppicelli et al.   CELL CYCLE

Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms

(2016) Veronika Simko et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic reprogramming as a continuous changing behavior of tumor cells

(2015) Silvia Peppicelli et al.   TUMOR BIOLOGY

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells

(2014) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

(2014) Olga Sedlakova   Frontiers in Physiology

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

(2013) PETER RADVAK et al.   ONCOLOGY REPORTS

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

(2013) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Additive Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells

(2013) Takao Matsubara et al.   Frontiers in Oncology

Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

(2011) X. Tang et al.   CANCER RESEARCH

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion

(2011) H.-J. Shin et al.   JOURNAL OF CELL SCIENCE

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

(2011) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target

(2009) Giuseppina De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS