Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 73, Pages 10312-10315Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05755a
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- CNR-DSB Progetto-Bandiera InterOmics''
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N-Unsubstituted carbamates have scarcely been investigated so far as carbonic anhydrase inhibitors (CAIs). By means of kinetic and structural studies, in this paper we demonstrate that such molecules can effectively inhibit hCAs and can be used as lead compounds for the development of CAIs possessing a binding mode similar to one of the CA substrates, bicarbonate.
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