The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

(2016) Laurent Counillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production

(2015) S. C. Chafe et al.   CANCER RESEARCH

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?

(2015) Schammim R. Amith et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The Na+/HCO3−Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

(2015) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

(2015) Dharmendra Dingar et al.   Journal of Proteomics

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2E3 Ligase Substrates

(2015) Etienne Coyaud et al.   MOLECULAR & CELLULAR PROTEOMICS

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

(2015) C Lodillinsky et al.   ONCOGENE

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

(2015) Carol Ward et al.   Oncotarget

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis

(2014) H.-Y. Jung et al.   CLINICAL CANCER RESEARCH

Hypoxia as a biomarker for radioresistant cancer stem cells

(2014) Claudia Peitzsch et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

(2014) Brian T. Beaty et al.   JOURNAL OF CELL BIOLOGY

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

(2014) I. R. Macpherson et al.   JOURNAL OF CELL SCIENCE

Matrix-Metalloproteinases in Head and Neck Carcinoma–Cancer Genome Atlas Analysis and Fluorescence Imaging in Mice

(2014) Samantha J. Hauff et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

(2014) C. Rosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of invadopodia by the tumor microenvironment

(2014) Christine M Gould et al.   Cell Adhesion & Migration

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Assessment of Hypoxia in the Stroma of Patient-Derived Pancreatic Tumor Xenografts

(2014) Ines Lohse et al.   Cancers

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

(2013) Begoña Díaz et al.   JOURNAL OF CELL BIOLOGY

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

(2013) Sara C. Hanna et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages Are More Potent Immune Suppressors Ex Vivo Than Immature Myeloid-Derived Suppressor Cells Induced by Metastatic Murine Mammary Carcinomas

(2013) M. J. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

(2013) PETER RADVAK et al.   ONCOLOGY REPORTS

HPV16 Oncoproteins Promote Cervical Cancer Invasiveness by Upregulating Specific Matrix Metalloproteinases

(2013) Jittranan Kaewprag et al.   PLoS One

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

(2013) Ian F. Robey et al.   Biomed Research International

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

(2012) A. McIntyre et al.   CLINICAL CANCER RESEARCH

Pathological roles of invadopodia in cancer invasion and metastasis

(2012) Hideki Yamaguchi   EUROPEAN JOURNAL OF CELL BIOLOGY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

(2011) P. Ditte et al.   CANCER RESEARCH

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

(2011) Marco A. O. Magalhaes et al.   JOURNAL OF CELL BIOLOGY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)

(2011) Fabrice Lucien et al.   PLoS One

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain

(2010) Magda Gioia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Scyl1 Facilitates Nuclear tRNA Export in Mammalian Cells by Acting at the Nuclear Pore Complex

(2010) Shawn C. Chafe et al.   MOLECULAR BIOLOGY OF THE CELL

ProHits: integrated software for mass spectrometry–based interaction proteomics

(2010) Guomin Liu et al.   NATURE BIOTECHNOLOGY

A guided tour of the Trans-Proteomic Pipeline

(2010) Eric W. Deutsch et al.   PROTEOMICS

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells

(2009) Taizo Tomari et al.   CANCER SCIENCE

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

Generating specificity and diversity in the transcriptional response to hypoxia

(2009) Urban Lendahl et al.   NATURE REVIEWS GENETICS

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

(2008) Yuanmei Lou et al.   DEVELOPMENTAL DYNAMICS

Promiscuous protein biotinylation by Escherichia coli biotin protein ligase

(2004) Eunjoo Choi-Rhee et al.   PROTEIN SCIENCE