Drug induced liver injury: an update

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury

(2019) Elizabeth T. Cirulli et al.   GASTROENTEROLOGY

EASL Clinical Practice Guidelines: Drug-induced liver injury

(2019) Raúl Andrade et al.   JOURNAL OF HEPATOLOGY

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

(2019) Tao Shen et al.   GASTROENTEROLOGY

Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies

(2019) Joseph J. Jennings et al.   Expert Opinion on Drug Metabolism & Toxicology

Epidemiology of drug-induced liver injury in a University Hospital from Colombia: Updated RUCAM being used for prospective causality assessment

(2019) Alejandra Cano-Paniagua et al.   Annals of Hepatology

Assessment of Serious Acute and Chronic Idiosyncratic Drug-Induced Liver Injury in Clinical Practice

(2019) Fernando Bessone et al.   SEMINARS IN LIVER DISEASE

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury

(2019) Natalie S Holman et al.   TOXICOLOGICAL SCIENCES

Development and Validation of Model Consisting of Comorbidity Burden to Calculate Risk of Death Within 6 months for Patients With Suspected Drug-Induced Liver Injury

(2019) Marwan Ghabril et al.   GASTROENTEROLOGY

Drug-Induced Liver Injury — Types and Phenotypes

(2019) Jay H. Hoofnagle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variation in the gut microbial community is associated with the progression of liver regeneration

(2019) Qiongling Bao et al.   HEPATOLOGY RESEARCH

Efficacy and safety of magnesium isoglycyrrhizinate injection in patients with acute drug‐induced liver injury: A phase II trial

(2019) Yongfeng Wang et al.   LIVER INTERNATIONAL

Drug-induced liver injury

(2019) Raul J. Andrade et al.   Nature Reviews Disease Primers

Clinical Characteristics and Adverse Impact of Hepatotoxicity due to Immune Checkpoint Inhibitors

(2019) Ethan D. Miller et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking

(2019) Maiquan Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Diagnostic and prognostic assessment of suspected drug‐induced liver injury in clinical practice

(2019) Raúl J. Andrade et al.   LIVER INTERNATIONAL

Drug Hepatotoxicity

(2019) Allyce Caines et al.   Clinics in Liver Disease

Drug-Induced Liver Injury Resources and Reporting for the Clinician

(2019) Marisa Isaacson et al.   Clinics in Liver Disease

Genetic Predisposition to Drug-Induced Liver Injury

(2019) Camilla Stephens et al.   Clinics in Liver Disease

Drug-Induced liver Injury Associated with Severe Cutaneous Hypersensitivity Reactions: A Complex Entity in Need of a Multidisciplinary Approach

(2019) Judith Sanabria-Cabrera et al.   CURRENT PHARMACEUTICAL DESIGN

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

(2018) Robim M. Rodrigues et al.   ARCHIVES OF TOXICOLOGY

Botanicals and Hepatotoxicity

(2018) Marina M. Roytman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

(2018) Lucija Kuna et al.   CURRENT DRUG METABOLISM

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

(2018) Rachel J. Church et al.   HEPATOLOGY

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22

(2018) Rebecca J. Brownlie et al.   IMMUNOLOGY

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications

(2018) Kalaiyarasi Kaliyaperumal et al.   JOURNAL OF HEPATOLOGY

Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors

(2018) Eleonora De Martin et al.   JOURNAL OF HEPATOLOGY

Interplay of gender, age and drug properties on reporting frequency of drug-induced liver injury

(2018) Nayana George et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Liver–Microbiome Axis in Health and Disease

(2018) Timon E. Adolph et al.   TRENDS IN IMMUNOLOGY

Animal models of drug-induced liver injury

(2018) Mitchell R. McGill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Can BSEP Inhibition Testing In Drug Discovery And Development Reduce Liver Injury Risk? - An International Transporter Consortium Perspective

(2018) J Gerry Kenna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug-induced liver injury with skin reactions: Drugs and host risk factors, clinical phenotypes and prognosis

(2018) Harshad Devarbhavi et al.   LIVER INTERNATIONAL

Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration

(2018) Xiaohe Xiao et al.   Acta Pharmaceutica Sinica B

Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues

(2017) Chofit Chai et al.   GASTROENTEROLOGY

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

(2017) Paola Nicoletti et al.   GASTROENTEROLOGY

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

Drug rechallenge following drug-induced liver injury

(2017) Christine M. Hunt et al.   HEPATOLOGY

Death and liver transplantation within 2 years of onset of drug-induced liver injury

(2017) Paul H. Hayashi et al.   HEPATOLOGY

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

(2017) Andrea Iorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response

(2017) Jessica Whritenour et al.   Journal of Immunotoxicology

Drug-induced acute liver failure in children and adults: Results of a single-centre study of 128 patients

(2017) Harshad Devarbhavi et al.   LIVER INTERNATIONAL

Histopathological challenges in suspected drug-induced liver injury

(2017) David E. Kleiner   LIVER INTERNATIONAL

Troglitazone Inhibits Bile Acid Amidation: A Possible Risk Factor for Liver Injury

(2017) Eiichiro Ogimura et al.   TOXICOLOGICAL SCIENCES

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

(2017) Rosa Chan et al.   TOXICOLOGICAL SCIENCES

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

(2017) Ian D. Wilson et al.   Translational Research

Clinical Features and Outcomes of Complementary and Alternative Medicine Induced Acute Liver Failure and Injury

(2016) Luke Hillman et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Drug-induced steatohepatitis

(2016) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Drug-induced liver and skin reactions: In need of a consensus definition

(2016) Inmaculada Medina-Cáliz et al.   HEPATOLOGY

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

(2016) Volker M. Lauschke et al.   HEPATOLOGY

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury

(2016) Inmaculada Medina-Caliz et al.   JOURNAL OF HEPATOLOGY

Pro-Euro-Dili Registry: A Collaborative Effort to Enhance the Understanding of Dili

(2016) M. Slim et al.   JOURNAL OF HEPATOLOGY

Prevalence, risk factors, management, and treatment outcomes of first-line antituberculous drug-induced liver injury: a prospective cohort study

(2016) Qin Sun et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis

(2016) Albert J Czaja   WORLD JOURNAL OF GASTROENTEROLOGY

Persistent Liver Biochemistry Abnormalities Are More Common in Older Patients and those With Cholestatic Drug Induced Liver Injury

(2015) Robert J Fontana et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Drug-Induced Liver Injury

(2015) Kurt Fisher et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Risk of Acute Liver Failure in Patients With Drug-Induced Liver Injury: Evaluation of Hy’s Law and a New Prognostic Model

(2015) Vincent Lo Re et al.   Clinical Gastroenterology and Hepatology

Secondary sclerosing cholangitis in patients with drug-induced liver injury

(2015) Hafsteinn O. Gudnason et al.   DIGESTIVE AND LIVER DISEASE

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients

(2015) Thomas Powles et al.   EUROPEAN JOURNAL OF CANCER

Population-Representative Incidence of Drug-Induced Acute Liver Failure Based on an Analysis of an Integrated Health Care System

(2015) David S. Goldberg et al.   GASTROENTEROLOGY

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury

(2015) Andreas Benesic et al.   GUT

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury

(2015) Seung-Hyun Kim et al.   HEPATOLOGY

Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports

(2015) Einar S. Björnsson et al.   HEPATOLOGY

Drug-induced liver injury associated with stevens-Johnson syndrome/toxic epidermal necrolysis: Patient characteristics, causes, and outcome in 36 cases

(2015) Harshad Devarbhavi et al.   HEPATOLOGY

RUCAM in Drug and Herb Induced Liver Injury: The Update

(2015) Gaby Danan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute liver failure following atorvastatin dose escalation: Is there a threshold dose for idiosyncratic hepatotoxicity?

(2015) Miguel F. Carrascosa et al.   JOURNAL OF HEPATOLOGY

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity

(2015) Mercedes Robles-Diaz et al.   LIVER INTERNATIONAL

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications

(2015) Lily Dara et al.   LIVER INTERNATIONAL

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Model for end-stage liver disease score as a predictor of short-term outcome in patients with drug-induced liver injury

(2015) Rubi Jeong et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

(2015) Felcy Pavithra Selwyn et al.   TOXICOLOGICAL SCIENCES

Peliosis hepatis: Personal experience and literature review

(2015) Daniele Crocetti   WORLD JOURNAL OF GASTROENTEROLOGY

Viral hepatitis prevalence in patients with active and latent tuberculosis

(2015) Hesam Ahmadi Nooredinvand   WORLD JOURNAL OF GASTROENTEROLOGY

Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases

(2015) Susana Rodrigues   WORLD JOURNAL OF GASTROENTEROLOGY

Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review

(2015) Jonathan G. Stine et al.   Expert Review of Gastroenterology & Hepatology

ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(2014) Naga P Chalasani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Causality Assessment for Suspected DILI During Clinical Phases of Drug Development

(2014) Arie Regev et al.   DRUG SAFETY

Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

(2014) Mercedes Robles–Diaz et al.   GASTROENTEROLOGY

Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives

(2014) Robert J. Fontana   GASTROENTEROLOGY

Spectrum of statin hepatotoxicity: Experience of the drug-induced liver injury network

(2014) Mark W. Russo et al.   HEPATOLOGY

Age-related differences in reporting of drug-associated liver injury: Data-mining of WHO Safety Report Database

(2014) Christine M. Hunt et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Drug-Induced Liver Injury with Autoimmune Features

(2014) David Foureau et al.   SEMINARS IN LIVER DISEASE

Amoxicillin/clavulanic acid-induced cholestatic liver injury after pediatric liver transplantation

(2013) Joanna Pawłowska   Annals of Transplantation

Current Challenges and Controversies in Drug-Induced Liver Injury

(2013) Alberto Corsini et al.   DRUG SAFETY

Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland

(2013) Einar S. Björnsson et al.   GASTROENTEROLOGY

Steroid use in acute liver failure

(2013) Jamuna Karkhanis et al.   HEPATOLOGY

Hepatic histological findings in suspected drug-induced liver injury: Systematic evaluation and clinical associations

(2013) David E. Kleiner et al.   HEPATOLOGY

Drug-induced liver injury in obesity

(2013) Bernard Fromenty   JOURNAL OF HEPATOLOGY

Acute Liver Failure

(2013) William Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

An automated causality assessment algorithm to detect drug-induced liver injury in electronic medical record data

(2013) T. Craig Cheetham et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Hepatitis C Virus Co-Infection Increases the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity among Patients with Pulmonary Tuberculosis

(2013) Nino Lomtadze et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Serum Glutamate Dehydrogenase—Biomarker for Liver Cell Death or Mitochondrial Dysfunction?

(2013) Hartmut Jaeschke et al.   TOXICOLOGICAL SCIENCES

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria

(2013) Derick Han et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Prospective Nationwide Study of Drug-Induced Liver Injury in Korea

(2012) Ki Tae Suk et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

(2012) Thomas J. Urban et al.   Pharmacogenetics and Genomics

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Steroid and Ursodesoxycholic Acid Combination Therapy in Severe Drug-Induced Liver Injury

(2011) Alexander Wree et al.   DIGESTION

A generic operational strategy to qualify translational safety biomarkers

(2011) Katja Matheis et al.   DRUG DISCOVERY TODAY

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Drug-Induced liver injury with hypersensitivity features has a better outcome: A single-center experience of 39 children and adolescents

(2011) Harshad Devarbhavi et al.   HEPATOLOGY

Causality assessment methods in drug induced liver injury: Strengths and weaknesses

(2011) Miren García-Cortés et al.   JOURNAL OF HEPATOLOGY

Hepatotoxicity associated with statins: Reports of idiosyncratic liver injury post-marketing

(2011) Einar Björnsson et al.   JOURNAL OF HEPATOLOGY

Nodular regenerative hyperplasia: Evolving concepts on underdiagnosed cause of portal hypertension

(2011) Marek Hartleb   WORLD JOURNAL OF GASTROENTEROLOGY

Evaluation of Naranjo Adverse Drug Reactions Probability Scale in causality assessment of drug-induced liver injury

(2010) M. GARCÍA-CORTÉS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Important Elements for the Diagnosis of Drug-Induced Liver Injury

(2010) Vijay K. Agarwal et al.   Clinical Gastroenterology and Hepatology

Safety of 3 Different Reintroduction Regimens of Antituberculosis Drugs after Development of Antituberculosis Treatment–Induced Hepatotoxicity

(2010) Surendra K. Sharma et al.   CLINICAL INFECTIOUS DISEASES

Standardization of nomenclature and causality assessment in drug-induced liver injury: Summary of a clinical research workshop

(2010) Robert J. Fontana et al.   HEPATOLOGY

Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment method

(2010) Don C. Rockey et al.   HEPATOLOGY

Drug-induced autoimmune hepatitis: Clinical characteristics and prognosis

(2010) Einar Björnsson et al.   HEPATOLOGY

Análisis de las causas, características y consecuencias de la reexposición al fármaco o compuesto responsable de un episodio de hepatotoxicidad

(2010) A. Fernández-Castañer et al.   REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS

Carnitine in the treatment of valproic acid-induced toxicity

(2009) Philippe E.R. Lheureux et al.   CLINICAL TOXICOLOGY

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

Ciprofloxacin Suppresses Cyp3a in Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora

(2009) Takahiro Toda et al.   Drug Metabolism and Pharmacokinetics

Drug-Induced Liver Injury Network (DILIN) Prospective Study

(2009) Robert J. Fontana et al.   DRUG SAFETY

Rechallenge in drug-induced liver injury: the attractive hazard

(2009) Raúl J Andrade et al.   Expert Opinion On Drug Safety

Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure

(2009) William M. Lee et al.   GASTROENTEROLOGY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histological patterns in drug-induced liver disease

(2009) R Ramachandran et al.   JOURNAL OF CLINICAL PATHOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury

(2008) James Rochon et al.   HEPATOLOGY

The long-term follow-up after idiosyncratic drug-induced liver injury with jaundice

(2008) Einar Björnsson et al.   JOURNAL OF HEPATOLOGY