Article
Gastroenterology & Hepatology
Genario Santos, Estela Regina Ramos Figueira, Luiz Augusto Carneiro D'Albuquerque, Paulo Bittencourt Lisboa, Marcio Dias de Almeida, Norma Arteiro Filgueira, Ilka Boin, Gilda Porta, Rita de Cassia Martins Alves da Silva, Cyntia Ferreira Gomes Viana, Luciana Costa Faria, Mario Reis Alvares-da-Silva, Adriano Claudio Pereira de Moraes, Daphne Benatti Goncalves Morsoletto, Liana Codes, Raymundo Parana
Summary: Based on the study findings, the main causes of acute liver failure in Brazil are unknown reasons and drug-induced liver injury, while acetaminophen toxicity and liver injury due to herbal and dietary supplements are uncommon.
ANNALS OF HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meng Li, Qiong Luo, Yanyan Tao, Xin Sun, Chenghai Liu
Summary: This article reviews the accumulated literature on drug-induced liver injury (DILI) with evidence-based medicine researches and discusses the limitations of clinical studies and the prospective development for DILI therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Katerina Roma, Salman Mohammed, Blake Sieck, Katrina Naik, Shahid Wahid
Summary: Alternative medicine supplements, such as kratoms, have become a significant cause of liver injury in the US. Reports of adverse events linked to kratom use are increasing, including liver injury, organ dysfunction, and even death. The need for increased regulation and public awareness of the risks associated with kratom is emphasized.
JOURNAL OF HEPATOLOGY
(2023)
Review
Integrative & Complementary Medicine
Zilong Zhang, Haibo Zou, Zonglin Dai, Jin Shang, Shining Sure, Chunyou Lai, Ying Shi, Qinyan Yang, Guangming Xiang, Yutong Yao, Tianhang Feng, Deyuan Zhong, Xiaolun Huang
Summary: Gynura segetum can rarely cause acute drug-induced liver injury (DILI) developing into acute liver failure (ALF). It is essential to timely prevent, identify, and manage DILI for patients with a history of taking Gynura segetum and other hepatotoxic drugs to avoid ALF.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Gastroenterology & Hepatology
Lin Han, Ang Huang, Jinjun Chen, Guangju Teng, Ying Sun, Binxia Chang, Hong-Li Liu, Manman Xu, Xiaoqin Lan, Qingsheng Liang, Jun Zhao, Hui Tian, Songhai Chen, Yun Zhu, Huan Xie, Tong Dang, Jing Wang, Ning Li, Xiaoxia Wang, Yu Chen, Yong-Feng Yang, Dong Ji, Zhengsheng Zou
Summary: This study aims to identify high-risk factors for non-acetaminophen (APAP) drug-induced acute liver failure (ALF) and develop a predictive model for transplant-free survival (TFS). Analysis of 482 patients with non-APAP drug-induced ALF revealed herbal and dietary supplements (HDS) as the most common causative agents. The DIALF-5 model, based on easily identifiable clinical data, accurately predicts 21-day TFS.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Fisheries
Shiyou Chen, Yan Lin, Linghong Miao, Wenjing Pan, Wenqiang Jiang, Linjie Qian, Jingyuan Hao, Bingwen Xi, Bo Liu, Xianping Ge
Summary: The study investigated the effects of ferulic acid (FA) on oxidative stress and inflammatory responses in blunt snout bream by creating a model of oxidative stress and inflammation through lipopolysaccharide (LPS) injection. FA treatment showed significant reductions in apoptosis rates, improvements in liver structure, enhanced antioxidant enzyme activities, and decreased pro-inflammatory cytokine levels, highlighting its potential as an effective antioxidant and anti-inflammatory agent in fish feed additives.
Article
Gastroenterology & Hepatology
Sabine Weber, Christine Woischke, Gerald Denk, Alexander L. Gerbes
Summary: This study found that individual laboratory markers or scores have limited predictive ability for orthotopic liver transplantation or death in drug-induced acute liver failure (DI-ALF). However, combinations of these scores have higher predictive ability.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huma Hameed, Muhammad Farooq, Celine Vuillier, Claire Piquet-Pellorce, Annaig Hamon, Marie-Therese Dimanche-Boitrel, Michel Samson, Jacques Le Seyec
Summary: This study reveals that RIPK1 plays a protective role in preventing hepatocyte apoptosis caused by acute liver injury. TNF-alpha and FasL have emerged as factors promoting hepatocyte survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Du, Mengmeng Teng, Luting Yang, Chao Meng, Yulan Qiu, Chuhui Wang, Jiaojiao Chen, Taotao Wang, Siying Chen, Yu Luo, Jinyao Sun, Yalin Dong
Summary: This study investigates the metabolic characteristics and potential mechanisms of Voriconazole (VOR) - induced liver injury. Plasma metabolic profiles were analyzed in a rat model of VOR - induced liver injury, and significant changes were observed in lipid metabolites and cholesterol and bile acids metabolites. Decreased fatty acids oxidation and bile acid excretion might be the potential mechanisms of VOR - induced liver injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Gastroenterology & Hepatology
Alexandra Shingina, Nizar Mukhtar, Jamile Wakim-Fleming, Saleh Alqahtani, Robert J. Wong, Berkeley N. Limketkai, Anne M. Larson, Lafaine Grant
Summary: Acute liver failure (ALF) is a rare, potentially reversible condition that causes severe liver damage and rapid clinical deterioration in patients without preexisting liver disease. Due to limited studies, guidelines provided by the American College of Gastroenterology serve as the official practice recommendations for the identification, treatment, and management of ALF. The guidelines were developed through a process of reviewing scientific evidence and using expert opinions when robust evidence was lacking. Individualized care should be applied in specific clinical scenarios due to the varied clinical presentations of ALF.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nanoscience & Nanotechnology
Peng Tang, Huiyin Wu, Mengru Wang, Ruihan Zhang, Bin Liang, Xiaoli Li, Weilie Xiao
Summary: In this study, linear poly(rosmarinic acid) nanomedicines were synthesized and showed improved therapeutic effects in the treatment of acute liver injury. This research suggests that drug-based backbone polymers provide a new approach for the development of versatile nanomedicines.
ACS APPLIED NANO MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Mercedes Robles-Diaz, Lana Nezic, Vesna Vujic-Aleksic, Einar S. Bjornsson
Summary: UDCA may have some benefits in the treatment and prevention of DILI according to available data, but a well designed RCT is needed to draw a firm conclusion on its efficacy in DILI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Xi Dong, Yun Luo, Shan Lu, Han Ma, Wenchao Zhang, Yue Zhu, Guibo Sun, Xiaobo Sun
Summary: This study demonstrates that ursodesoxycholic acid (UDCA) can alleviate liver fibrosis by promoting liver regeneration through activation of the ID1-WNT2/hepatocyte growth factor (HGF) pathway. Additionally, it was found that Id1 plays a crucial role in the protective effects of UDCA against liver fibrosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Bolin Zhu, Bing Liu, Guodong Tang, Pengfei Jin, Deping Liu
Summary: This paper presents two unusual cases of febuxostat-induced acute liver injury. Two patients with heart failure developed febuxostat-induced hepatotoxicity during their hospital stay. The paper provides a detailed description of the medical history, drug treatment, clinical symptoms, liver function tests, diagnosis, and prognosis. The researchers suggest further investigation to determine whether heart failure is a risk factor for febuxostat-related liver injury.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Review
Cell & Tissue Engineering
Jia-Hang Zhou, Xuan Lu, Cui-Lin Yan, Xin-Yu Sheng, Hong-Cui Cao
Summary: Studies have shown that mesenchymal stromal cells (MSCs) alleviate chemically-induced acute liver injury in animal models and interact with immune cells, which may serve as an effective strategy for treating drug-induced liver injury (DILI) in humans.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Gastroenterology & Hepatology
David M. Calcagno, Angela Chu, Susanne Gaul, Nika Taghdiri, Avinash Toomu, Aleksandra Leszczynska, Benedikt Kaufmann, Bettina Papouchado, Alexander Wree, Lukas Geisler, Hal M. Hoffman, Ariel E. Feldstein, Kevin R. King
Summary: Activation of NLRP3 causes chronic extramedullary myelopoiesis in the liver, leading to inflammation and fibrosis. This activation also down-regulates metabolic pathways in hepatocytes and shifts hepatic stellate cells towards an activated profibrotic state.
Review
Biochemistry & Molecular Biology
Jana Knorr, Alexander Wree, Ariel E. Feldstein
Summary: This review discusses the key molecular and cellular processes that induce pyroptosis in the liver and its significance in the pathogenesis of common liver diseases in different human and experimental mouse studies.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Peter Lemmer, Paul Manka, Jan Best, Alisan Kahraman, Julia Kaelsch, Ramiro Vilchez-Vargas, Alexander Link, Hsin Chiang, Guido Gerken, Ali Canbay, Lars P. Bechmann, Svenja Sydor
Summary: Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver diseases worldwide. While clinically distinguished by alcohol consumption, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Studies have shown that even moderate alcohol consumption has impacts on liver injury, lipid metabolism, and the composition of gut microbiota.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marten Schulz, Anne-Christin B. Wilde, Muenevver Demir, Tobias Mueller, Frank Tacke, Alexander Wree
Summary: This study characterized the severity of liver disease in PBC patients using non-invasive methods including 2D-SWE, SWD, and ATI. The results demonstrate the reliability of 2D-SWE for fibrosis assessment in PBC, and the correlation of SWD with the prognostic marker ALP suggests a potentially valuable role of this new non-invasive method in evaluating liver disease activity in PBC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Paul Manka, Svenja Sydor, Julia M. Schaenzer-Ocklenburg, Malte Brandenburg, Jan Best, Ramiro Vilchez-Vargas, Alexander Link, Dominik Heider, Susanne Brodesser, Anja Figge, Andreas Jaehnert, Jason D. Coombes, Francisco Javier Cubero, Alisan Kahraman, Moon-Sung Kim, Julia Kaelsch, Sonja Kinner, Klaas Nico Faber, Han Moshage, Guido Gerken, Wing-Kin Syn, Ali Canbay, Lars P. Bechmann
Summary: Even in CeD patients in clinical remission under a gluten-free diet, alterations in gut-liver axis, especially bile acid signaling, may contribute to steatotic liver injury.
Review
Medicine, General & Internal
Christian Liedtke, Yulia A. Nevzorova, Tom Luedde, Henning Zimmermann, Daniela Kroy, Pavel Strnad, Marie-Luise Berres, Juergen Bernhagen, Frank Tacke, Jacob Nattermann, Ulrich Spengler, Tilman Sauerbruch, Alexander Wree, Zeinab Abdullah, Rene H. Tolba, Jonel Trebicka, Twan Lammers, Christian Trautwein, Ralf Weiskirchen
Summary: The Transregional Collaborative Research Center on Organ Fibrosis conducted a 13-year study to gain detailed knowledge on the mechanisms, immunological factors, and therapeutic approaches of organ fibrosis. This review summarizes the key findings in liver fibrogenesis, including cell death and cell cycle pathways, nutritional and iron-related mechanisms, and immune cell compartments. Potential signaling pathways and pharmacological targets are also highlighted for improved therapy and diagnosis of liver fibrosis.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Svenja Sydor, Christian Dandyk, Johannes Schwerdt, Paul Manka, Dirk Benndorf, Theresa Lehmann, Kay Schallert, Maximilian Wolf, Udo Reichl, Ali Canbay, Lars P. Bechmann, Robert Heyer
Summary: High-calorie diets can lead to liver diseases and disruptions in the gut microbiome. Analyzing medical parameters and fecal metaproteome can help identify biomarkers for diagnosing non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Machine learning algorithms achieved high accuracy in distinguishing between healthy controls, NASH, and HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Julian Pohl, Philip Bischoff, Robert Oellinger, Wenzel Schoening, Georg Lurje, Johann Pratschke, David Horst, Frank Tacke, Alexander Wree
Summary: Metamizole, a commonly prescribed analgetic drug, can cause liver injury. Although there are only a few reported cases of metamizole-associated liver injury, it can lead to acute liver failure requiring liver transplantation. A recent study from Germany reported a larger cohort of metamizole-related liver injury cases, drawing wider attention to this issue. In our study, we report two cases of acute liver failure requiring emergency liver transplantation due to the use of metamizole as a pain medication. Pathology assessment confirmed the diagnosis of metamizole-associated liver injury. This rare but potentially overlooked adverse drug effect should be considered as a differential diagnosis in cases of cryptogenic liver failure.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Gastroenterology & Hepatology
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtman, Lukas Geisler, Jana L. Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin-Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Milnevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree
Summary: This study reveals the role of IL-18 in the development of liver fibrosis by directly affecting HSC activation, identifying IL-18 as a potential target for the treatment of liver fibrosis.
Article
Gastroenterology & Hepatology
Fabian Jost-Brinkmann, Muenevver Demir, Alexander Wree, Tom Luedde, Sven H. Loosen, Tobias Mueller, Frank Tacke, Christoph Roderburg, Raphael Mohr
Summary: The combination of atezolizumab and bevacizumab has been established as the standard treatment for unresectable hepatocellular carcinoma. However, concerns about its efficacy in non-viral HCC and its safety in patients with advanced cirrhosis remain. This study found that atezolizumab plus bevacizumab showed good efficacy and safety in patients with unresectable HCC, including those with advanced cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Linde Kehmann, Marie-Luise Berres, Maria Gonzalez-Carmona, Dominik P. Modest, Raphael Mohr, Alexander Wree, Marino Venerito, Christian Strassburg, Verena Keitel, Christian Trautwein, Tom Luedde, Christoph Roderburg
Summary: This study aims to evaluate the safety and efficacy of trifluridine/tipiracil plus irinotecan in patients with biliary tract cancer refractory to previous gemcitabine based treatment.
Article
Medicine, Research & Experimental
Klaus Stahl, Friederike Klein, Torsten Voigtlaender, Anika Grosshennig, Thorsten Book, Tobias M. Mueller, Alexander Wree, Armin Kuellmer, Jochen I. Weigt, Alexander Dechene, Edris Wedi, Arne Kandulski, Christian Lange, Dennis Holzwart, Dorothee von Witzendorff, Kristina Ringe, Heiner M. Wedemeyer, Benjamin Heidrich
Summary: The BISCIT study aims to demonstrate that scheduled biliary interventions can reduce the incidence of cholangiosepsis, liver transplantation, or death in patients with secondary sclerosing cholangitis in critically ill patients (SSC-CIP). A total of 104 patients will be randomized to receive either scheduled biliary interventions or standard of care, and the occurrence of death, liver transplantation, or cholangiosepsis within 6 months will be observed. The results of this study will be disseminated through international congresses, workshops, and peer-reviewed publications.
Article
Health Care Sciences & Services
Sotiria Bedreli, Paul Manka, Matthias Buechter, Michael Jahn, Jens M. Theysohn, Ali Canbay, Antonios Katsounas
Summary: This pilot study aimed to evaluate the changes and differences in coagulation function between peripheral circulation (PERC) and portal circulation (PORC) in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) surgery. The results showed that there were no differences in coagulation function between PERC and PORC, which contradicted previous studies. Therefore, the evaluation of coagulation function in PERC using rotational thromboelastometry can reliably reflect the coagulation function in PORC.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Felix Bolduan, Dominik Geisel, Stefan Pahl, Alexander Wree, Frank Tacke
JOURNAL OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Suzan Schwertheim, Malek Alhardan, Paul P. Manka, Jan-Peter Sowa, Ali Canbay, Hartmut H. -J. Schmidt, Hideo A. Baba, Julia Kaelsch
Summary: Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver conditions, from mild fatty liver (NAFL) to more severe non-alcoholic steatohepatitis (NASH) with inflammation and cirrhosis. This study investigates the proteins involved in the progression from NAFL to NASH, and found that pNRF2, SOCS3, IRF3, and RIG1 play a role in hepatic lipid metabolism. These proteins may have potential as therapeutic targets for NAFLD/NASH treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
