Article
Oncology
Jiang Li, Haisu Tao, Erlei Zhang, Zhiyong Huang
Summary: The study evaluated the diagnostic value of GAPR combined with GAR and AAR in AFP-negative hepatocellular carcinoma patients. The combination of these ratios was effective in distinguishing AFP-negative HCC group from control, chronic hepatitis, and liver cirrhosis groups, especially in patients with good liver function, early stage, or small tumor size.
Article
Cardiac & Cardiovascular Systems
Athiththan Yogeswaran, Khodr Tello, Jonas Lund, Hans Klose, Lars Harbaum, Natascha Sommer, Tim Oqueka, Jan K. Hennigs, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Manuel J. Richter, Henning Gall
Summary: This study assessed the prognostic value of gamma-glutamyl transferase (GGT), aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, and neutrophil-to-lymphocyte ratio (NLR) in patients with pulmonary arterial hypertension (PAH). A scoring system based on these biomarkers showed high predictive power and was comparable to the existing risk stratification scheme.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Oncology
Wenlong Wu, Quancheng Wang, Dandan Han, Jianhui Li, Ye Nie, Dongnan Guo, Long Yang, Kaishan Tao, Xuan Zhang, Kefeng Dou
Summary: The study confirmed that the preoperative GPR and ALR-GPR-PLR score models were independent predictors for DFS and OS in patients with HCC, and showed good performance in stratifying patients with different outcomes.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Nao Sukeda, Hidetsugu Fujigaki, Tatsuya Ando, Honomi Ando, Yasuko Yamamoto, Kuniaki Saito
Summary: Cisplatin is a chemotherapeutic drug used for treating malignant tumors, but nephrotoxicity is a dose-limiting factor. The study identified 2',4',6'-trihydroxyacetophenone (THA) as an inhibitor of cisplatin-induced nephrotoxicity. THA pretreatment can effectively alleviate cisplatin-induced kidney damage.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Weijie Chen, Danmian Hong, Zeliang Chen, Xiaoqing Dai, Jing Cao, Min Yu, Liping Li
Summary: This study investigated the reference ranges of GPR and GLR in the Chinese Han population in the Chaoshan region of South China. The study found that GPR and GLR varied with age and sex.
BMC GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hemily Batista-Silva, Betina Fernanda Dambros, Kieiv Resende Sousa de Moura, Nicolas Elie, Christelle Delalande, Glen van der Kraak, Fatima Regina Mena Barreto Silva
Summary: This study investigated the effects of varying environmental Ca2+ concentrations on the influx of Ca2+ to the testis, testicular morphology, and liver enzymes in the zebrafish. The results showed that different Ca2+ concentrations in the water can affect the influx of Ca2+ in the testis, cause morphological changes in the testes, and induce liver damage.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lin He, Dennis Kai Ming Ip, Greta Tam, Vincent Chi Hang Lui, Paul Kwong Hang Tam, Patrick Ho Yu Chung
Summary: A systematic review of studies evaluating biomarkers for BA diagnosis and post-KPE prognosis showed that MMP-7, IL-33, and GGT are useful for diagnosing BA, while APRi can predict liver fibrosis and cirrhosis after KPE. These noninvasive biomarkers can be integrated into BA management protocols.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Elnaz Lorzadeh, Mohsen Akhondi-Meybodi, Hassan Mozaffari-Khosravi, Masoud Mirzaei, Amin Salehi-Abargouei
Summary: This study in Iranian adults found that a western dietary pattern was associated with adverse effects on serum GGT levels, increasing the likelihood of developing abnormal enzyme levels. However, traditional and hydrogenated fat and sugar dietary patterns did not show the same association with liver enzymes.
Article
Agriculture, Multidisciplinary
Eshita Sharma, Milan Kumar Lal, Arvind Gulati, Ashu Gulati
Summary: An extracellular gamma-glutamyl transpeptidase (GGT) from Bacillus altitudinis IHB B1644 was purified using ion-exchange chromatography, and it was composed of two subunits of 40 and 22 kDa determined by SDS-PAGE. The enzyme showed optimal activity at pH 9 and 37 degrees C, and it was stable in a pH range of 5-10 and below 50 degrees C. The enzyme exhibited highest affinity for L-methionine and serine or threonine and tryptophan residues were found to be essential for its activity. The production of L-theanine was optimized by a one-variable-at-a-time approach with a conversion rate of 60-65%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Xiang-An Zhao, Jian Wang, Jie Wei, Jiacheng Liu, Guangmei Chen, Li Wang, Guiyang Wang, Juan Xia, Weihua Wu, Shengxia Yin, Xin Tong, Xiaomin Yan, Weimao Ding, Xiaoxing Xiang, Rui Huang, Chao Wu
Summary: The study found that some HBeAg-negative CHB patients have significant liver inflammation or fibrosis, and GPR is an accurate predictor for predicting liver inflammation and fibrosis in these patients.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Oncology
Yunshi Cai, Bohan Zhang, Jiaxin Li, Hui Li, Hailing Liu, Kunlin Xie, Chengyou Du, Hong Wu
Summary: The study found that GPR and INR had higher prognostic value in ICC patients compared to other indexes. Patients with a high GPR-INR score had significantly decreased overall survival and recurrence-free survival. The proposed nomogram based on GPR-INR score showed good consistency and representation in clinical practice.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xiang-An Zhao, Jian Wang, Jie Wei, Jiacheng Liu, Guangmei Chen, Li Wang, Guiyang Wang, Juan Xia, Weihua Wu, Shengxia Yin, Xin Tong, Xiaomin Yan, Weimao Ding, Xiaoxing Xiang, Rui Huang, Chao Wu
Summary: More than half of HBeAg-negative CHB patients with detectable HBV DNA and normal ALT levels exhibited significant liver inflammation or fibrosis. GPR can serve as an accurate predictor of liver inflammation and fibrosis in these patients.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Hironobu Nishijima, Matthew J. Zunitch, Masafumi Yoshida, Kenji Kondo, Tatsuya Yamasoba, James E. Schwob, Eric H. Holbrook
Summary: This study identified two fluorescence probes that can rapidly detect and evaluate the entire extent of mice OE. These probes can be used to monitor OE degeneration and the regenerative response to therapeutic interventions.
Article
Chemistry, Multidisciplinary
Yohei Kondo, Yutaro Saito, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Tatsuya Nishihara, Marino Itoda, Hiroshi Nonaka, Masayuki Matsuo, Shinsuke Sando
Summary: Dynamic nuclear polarization (DNP) is an emerging method for acquiring metabolic and physiological information in vivo. The development of a deuterated probe, gamma-Glu-[1-C-13]Gly-d(2), has been shown to extend the lifetime of hyperpolarized signals. By evaluating enzymatic conversion and magnetic properties, this study confirms the effectiveness of gamma-Glu-[1-C-13]Gly as a DNP NMR molecular probe for detecting GGT activity in serum.
Review
Plant Sciences
Takehiro Ito, Naoko Ohkama-Ohtsu
Summary: GSH is an essential thiol for plants, but its degradation has not been fully elucidated, limiting our understanding of plant life. Recent studies have shown that GSH is degraded by cytosolic enzymes or after conjugation with other molecules. This highlights the need to reassess previous assumptions and provide a novel overview of the plant GSH degradation pathway. This review aims to summarize current understanding of GSH/glutathione conjugate degradation and lay a foundation for future studies.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Gastroenterology & Hepatology
Javier Crespo, Joaquin Cabezas, Antonio Aguilera, Marina Berenguer, Maria Buti, Xavier Forns, Federico Garcia, Javier Garcia-Samaniego, Manuel Hernandez-Guerra, Francisco Jorquera, Jeffrey Lazarus, Sabela Lens, Elisa Martro, Juan Antonio Pineda, Martin Prieto, Francisco Rodriguez-Frias, Manuel Rodriguez, Miguel Angel Serra, Juan Turnes, Raquel Dominguez-Hernandez, Miguel Angel Casado, Jose Luis Calleja
Summary: The Spanish Society of Digestive Pathology (SEPD), the Spanish Association for the Study of the Liver (AEEH), the Spanish Society of Infections and Clinical Microbiology (SEIMC) and its Viral Hepatitis Study Group (GEHEP), with the endorsement of the Alliance for the Elimination of Viral Hepatitis in Spain (AEHVE), have developed a document for comprehensive diagnosis of viral hepatitis (B, C, and D) from a single blood sample. They propose an algorithm to analyze the rest of the viruses, including viral load, when a positive result for viral hepatitis or HIV is found in the blood sample. They also recommend ruling out previous hepatitis A virus infection and determining the HIV serology. Automated alerts and epidemiological monitoring should be initiated in case of a positive result for any of the viruses.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Gastroenterology & Hepatology
Jiaxu Liang, Javier Ampuero, Javier Castell, Qiong Zhang, Sijia Zhang, Yong Chen, Manuel Romero-Gomez
Summary: Hepatocellular carcinoma (HCC) is a major public health problem worldwide and is closely related to liver fibrosis. Magnetic resonance elastography (MRE) has emerged as a non-invasive technique with excellent diagnostic accuracy for assessing liver fibrosis and tumor stiffness. Recent studies have shown that MRE has several novel clinical applications in HCC management, including predicting HCC development, differentiating between benign/malignant liver lesions and HCC pathological grades, assessing treatment response, and predicting recurrence after treatment. However, some findings are controversial. This review summarizes the novel applications of MRE in HCC patients and discusses their limitations and future advancement.
ANNALS OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laura Ramos, Cristina Reygosa, Marta Carrillo-Palau, Inmaculada Alonso-Abreu, Yanira Gonzalez-Mendez, Raquel de la Barreda, Carla Amaral, Anjara Hernandez, Federica Benitez-Zafra, Manuel Hernandez-Guerra
Summary: This study assesses the efficacy, efficiency, patient satisfaction, and acceptability of using telephone consultation in an IBD unit. The results show that telephone consultation is effective and efficient in caring for IBD patients during the COVID-19 pandemic, and it is well accepted by patients.
DIGESTIVE DISEASES
(2023)
Article
Pharmacology & Pharmacy
Eva Montane, Javier Santesmases
Summary: This study describes the characteristics of safety alerts issued by the Spanish Medicines Agency over a 7-year period and the regulatory actions they generated. The results showed that a total of 126 safety alerts were issued during this period, with 92 alerts reporting 147 adverse drug reactions (ADRs) involving 84 drugs. The study highlights the importance of spontaneous reporting of ADRs and the need to assess safety throughout the lifecycle of medicines.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Jose Ignacio Fortea, Angela Puente, Javier Crespo, Emilio Fabrega
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Review
Biology
Antonio Olveira, Salvador Augustin, Salvador Benlloch, Javier Ampuero, Jorge Alonso Suarez-Perez, Susana Armesto, Eva Vilarrasa, Isabel Belinchon-Romero, Pedro Herranz, Javier Crespo, Francisco Guimera, Lara Gomez-Labrador, Victor Martin, Jose Manuel Carrascosa
Summary: IL-17 plays a crucial role in the pathogenesis of both psoriasis and MAFLD. It is mainly produced by TH17 and Tc17 cells, but other cells also contribute to its production. IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and is implicated in the development of fibrosis and insulin resistance. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could improve metabolic and liver parameters.
Article
Dermatology
J. M. Carrascosa, E. Vilarrasa, I. Belinchon, P. Herranz, J. Crespo, F. Guimera, A. Olveira
Summary: In recent years, efforts have been made to understand the relationship between psoriasis and metabolic-associated fatty liver disease (MAFLD). MALFD is not only diagnosed more frequently in patients with psoriasis but also has a more aggressive clinical course. Therefore, a common approach is needed for early detection of liver disease in patients with psoriasis. It is important to analyze the risks and benefits of potentially hepatotoxic treatments. This consensus paper presents the recommendations of experts in dermatology and hepatology regarding screening for MALFD and criteria for monitoring patients and referring them to hepatologists when liver disease is suspected.
ACTAS DERMO-SIFILIOGRAFICAS
(2023)
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Aitor Odriozola, Alvaro Santos-Laso, Maria del Barrio, Joaquin Cabezas, Paula Iruzubieta, Maria Teresa Arias-Loste, Coral Rivas, Juan Carlos Rodriguez Duque, Angela Anton, Emilio Fabrega, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ArLD) are both well-known causes of liver damage, leading to the progression of liver disease and liver-related events. The impact of alcohol consumption on NAFLD patients is still debated, as it is unclear whether low to moderate alcohol consumption is beneficial or detrimental to liver health. Identifying and measuring the synergistic deleterious effect of alcohol consumption in patients with NAFLD is crucial for clinicians to improve the prognosis of patients with both NAFLD and alcohol-related liver disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Del Barrio, Lucia Lavin, Alvaro Santos-Laso, Maria Teresa Arias-Loste, Aitor Odriozola, Juan Carlos Rodriguez-Duque, Coral Rivas, Paula Iruzubieta, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) currently. Lifestyle change is the only available therapeutic recommendation, but adherence to this approach is often challenging. Manipulation of the microbiota and improving intestinal permeability may offer promising therapeutic strategies for NAFLD. Faecal microbiota transplantation (FMT) is a potential method to achieve this. In this review, we summarize key aspects of FMT, discuss its current indications, and highlight recent advances in NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Dan Dumitrascu, Igor Bakulin, Annalisa Berzigotti, Marilia Cravo, Laura Gombosova, Milan Lukas, Anna Pietrzak, Jose Maria Remes-Troche, Manuel Romero-Gomez, Mercedes Amieva Balmori, Tiago Curdia Goncalves, Lamine Hamzaoui, Radovan Juricek, Leticia Moreira, Katarzyna Neubauer, Teodora Surdea-Blaga, Igor N. Tikhonov, Jan Trna, Gianluca Ianiro, Francesca Romana Ponziani, Antonio Gasbarrini
Summary: Various environmental factors can lead to gut microbial imbalance and the development of diseases. Hepatic encephalopathy, irritable bowel syndrome, and diverticular disease are all related to dysfunction of the gut-liver-brain axis, but the pathophysiology differs for each condition.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2023)
Article
Nutrition & Dietetics
Diego Casas-Deza, Vanesa Bernal-Monterde, Elena Betore-Glaria, Ana Belen Julian-Gomara, Carmen Yague-Caballero, Alejandro Sanz-Paris, Eva Maria Fernandez-Bonilla, Javier Fuentes-Olmo, Jose M. Arbones-Mainar
Summary: This study evaluated the ability of the Liver Disease Undernutrition Screening Tool (LDUST) to predict mortality and decompensation in outpatients with clinically significant portal hypertension (CSPH). The results showed that LDUST could help identify patients in need of nutritional supplementation and intervention. Combining LDUST with Child and MELD scores improved their decompensation prediction.
Article
Education, Scientific Disciplines
Eva Montane, Cristina Vilaplana, Joan Riera, Marina Pujol, Maria Mendez, Albert Mas, Angel Vara, David Pares
Summary: The aim of this study was to analyze the opinion of medical students about their learning process and the influence of their experience according to their year of medical degree. The study found that student motivation and teaching quality were generally high, and student-teacher interaction and new learning technological tools were important for student motivation. Late-year students showed a higher interest in becoming part of a medical team and in learning to write scientific articles. The study concluded that the year of career had little influence on the medical students' opinion on their learning process, and the use of new technologies and student-teacher interaction is essential for student motivation.
MEDICAL SCIENCE EDUCATOR
(2023)