Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

Death and liver transplantation within 2 years of onset of drug-induced liver injury

(2017) Paul H. Hayashi et al.   HEPATOLOGY

Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia

(2016) Mila Rivkin et al.   GASTROENTEROLOGY

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance

(2016) Mark W. Russo et al.   LIVER INTERNATIONAL

Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury

(2016) Maria Mikus et al.   LIVER INTERNATIONAL

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

(2016) Natalie S. Holman et al.   TOXICOLOGICAL SCIENCES

Persistent Liver Biochemistry Abnormalities Are More Common in Older Patients and those With Cholestatic Drug Induced Liver Injury

(2015) Robert J Fontana et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Plasma osteopontin in acute liver failure

(2015) Praveen Srungaram et al.   CYTOKINE

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

(2014) Mercedes Robles–Diaz et al.   GASTROENTEROLOGY

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis

(2013) James W. Dear et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

(2013) Petra Thulin et al.   LIVER INTERNATIONAL

Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: Results of a double-blind randomized clinical trial

(2013) Kevin M. Flanigan et al.   NEUROMUSCULAR DISORDERS

Assessment of Emerging Biomarkers of Liver Injury in Human Subjects

(2013) Shelli Schomaker et al.   TOXICOLOGICAL SCIENCES

Alanine Aminotransferase: A Clinical and Regulatory Tool for Detecting Liver Injury–Past, Present, and Future

(2012) J R Senior   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

(2012) A H Harrill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A generic operational strategy to qualify translational safety biomarkers

(2011) Katja Matheis et al.   DRUG DISCOVERY TODAY

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury

(2010) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

Serum Transaminase Levels in Boys With Duchenne and Becker Muscular Dystrophy

(2010) H. J. McMillan et al.   PEDIATRICS

A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

(2009) Ulf Andersson et al.   BIOMARKERS

Drug-Induced Liver Injury Network (DILIN) Prospective Study

(2009) Robert J. Fontana et al.   DRUG SAFETY

Muscular exercise can cause highly pathological liver function tests in healthy men

(2007) Jonas Pettersson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY