Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
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Title
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
Authors
Keywords
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Journal
Cells
Volume 9, Issue 7, Pages 1638
Publisher
MDPI AG
Online
2020-07-10
DOI
10.3390/cells9071638
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Note: Only part of the references are listed.- A 3‐week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death
- (2020) François Briand et al. CTS-Clinical and Translational Science
- Efficacy and safety of anti-hyperglycaemic drugs in patients with non-alcoholic fatty liver disease with or without diabetes: An updated systematic review of randomized controlled trials
- (2020) A. Mantovani et al. DIABETES & METABOLISM
- Towards genetic prediction of non-alcoholic fatty liver disease trajectories: PNPLA3 and beyond
- (2020) Marcin Krawczyk et al. GASTROENTEROLOGY
- Synbiotic Alters Fecal Microbiomes, but not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Non-alcoholic Fatty Liver Disease
- (2020) Eleonora Scorletti et al. GASTROENTEROLOGY
- Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis
- (2020) Rod S. Taylor et al. GASTROENTEROLOGY
- Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
- (2020) Anand R. Saran et al. GASTROENTEROLOGY
- Therapeutic landscape for NAFLD in 2020
- (2020) Brent A. Neuschwander-Tetri GASTROENTEROLOGY
- Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease
- (2020) Vian Azzu et al. GASTROENTEROLOGY
- Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations
- (2020) Mayu Kawasaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regulation of lipid‐induced macrophage polarization through modulating PPAR‐γ activity affects hepatic lipid metabolism via TLR4/NF‐κB signaling pathway
- (2020) Hui‐Min Wu et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Update on NAFLD genetics: from new variants to the clinic
- (2020) Eric Trépo et al. JOURNAL OF HEPATOLOGY
- The role of nutrition in non‐alcoholic fatty liver disease: Pathophysiology and management
- (2020) Genoveva Berná et al. LIVER INTERNATIONAL
- Current management of non‐alcoholic steatohepatitis
- (2020) Mark D. Muthiah et al. LIVER INTERNATIONAL
- Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis
- (2020) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study
- (2020) Yang Xia et al. Nutrition & Metabolism
- Exercise Training-Induced PPARβ Increases PGC-1α Protein Stability and Improves Insulin-Induced Glucose Uptake in Rodent Muscles
- (2020) Ju-Sik Park et al. Nutrients
- Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis
- (2020) Naoki Yoshioka et al. Scientific Reports
- Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
- (2020) Yachen Shen et al. Cell Reports
- PPAR-Mediated Toxicology and Applied Pharmacology
- (2020) Yue Xi et al. Cells
- Managing NAFLD in Type 2 Diabetes: The Effect of Lifestyle Interventions, a Narrative Review
- (2020) Siôn A. Parry et al. ADVANCES IN THERAPY
- Bariatric Surgery is Associated With Decreased Progression of Nonalcoholic Fatty Liver Disease to Cirrhosis
- (2020) Keith M. Wirth et al. ANNALS OF SURGERY
- Physical activity intervention for non-diabetic patients with non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials
- (2020) Shu-ting Wang et al. BMC GASTROENTEROLOGY
- Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
- (2020) Xiaobo Wang et al. Cell Metabolism
- PPARα and NCOR/SMRT corepressor network in liver metabolic regulation
- (2020) Zhanfang Kang et al. FASEB JOURNAL
- Nonalcoholic Fatty Liver Disease in Children: Unique Considerations and Challenges
- (2020) Dana Goldner et al. GASTROENTEROLOGY
- Genetic pathways in nonalcoholic fatty liver disease: Insights from systems biology
- (2020) Silvia Sookoian et al. HEPATOLOGY
- Hepatic molecular signatures highlight the sexual dimorphism of Non‐Alcoholic SteatoHepatitis (NASH)
- (2020) Jimmy Vandel et al. HEPATOLOGY
- Nutrition and Genetics in NAFLD: The Perfect Binomium
- (2020) Marica Meroni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
- (2020) Yaping Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk
- (2020) Rohit A. Sinha et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent
- (2020) Guillaume Grzych et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages
- (2020) Sander Lefere et al. JOURNAL OF HEPATOLOGY
- Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort
- (2020) Quentin M. Anstee et al. JOURNAL OF HEPATOLOGY
- Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
- (2020) Steven Zhao et al. NATURE
- Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders
- (2020) Judith Aron-Wisnewsky et al. Nature Reviews Gastroenterology & Hepatology
- Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature
- (2020) Mikiko Watanabe et al. Obesity Reviews
- Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease
- (2020) Panu K. Luukkonen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
- (2020) Yusuke Sasaki et al. Scientific Reports
- Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
- (2020) Marion Régnier et al. Scientific Reports
- PPAR Beta/Delta and the Hallmarks of Cancer
- (2020) Nicole Wagner et al. Cells
- Effect of saroglitazar 2 mg and 4 mg on glycemic control, lipid profile and cardiovascular disease risk in patients with type 2 diabetes mellitus: a 56-week, randomized, double blind, phase 3 study (PRESS XII study)
- (2020) Manjunath Krishnappa et al. Cardiovascular Diabetology
- Elafibranor Interrupts Adipose Dysfunction-mediated Gut and Liver Injury in Mice with Alcoholic Steatohepatitis
- (2019) Tzu-Hao Li et al. CLINICAL SCIENCE
- Interactions between Host PPARs and Gut Microbiota in Health and Disease
- (2019) Arif Hasan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NASH in Lean Individuals
- (2019) Ramy Younes et al. SEMINARS IN LIVER DISEASE
- Post hoc analyses of surrogate markers of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis in patients with type 2 diabetes in a digitally supported continuous care intervention: an open-label, non-randomised controlled study
- (2019) Eduardo Vilar-Gomez et al. BMJ Open
- The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
- (2019) Antonio Paoli et al. Nutrients
- A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease
- (2019) Walid Kamal Abdelbasset et al. MEDICINE
- TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population
- (2019) Qun Liu et al. Lipids in Health and Disease
- Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis
- (2019) Noha F. Hassan et al. INFLAMMATION
- Sex Differences in NAFLD : State of the Art and Identification of Research Gaps
- (2019) Amedeo Lonardo et al. HEPATOLOGY
- A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21
- (2019) Steven A. Kliewer et al. Cell Metabolism
- Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis
- (2019) Satoshi Ida et al. Cardiovascular Diabetology
- Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis – Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue
- (2019) Samuel J. Daniels et al. BIOMEDICINE & PHARMACOTHERAPY
- Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial
- (2019) Kathleen E. Corey et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels
- (2019) Hayden Weng Siong Tan et al. Autophagy
- Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway
- (2019) Wenxi He et al. DIGESTIVE DISEASES AND SCIENCES
- Unexpected Rapid Increase in the Burden of Nonalcoholic Fatty Liver Disease in China From 2008 to 2018: A Systematic Review and Meta‐Analysis
- (2019) Feng Zhou et al. HEPATOLOGY
- Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
- (2019) Ning Liang et al. Nature Communications
- Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis
- (2019) Meredith A Sommars et al. eLife
- New dual peroxisome proliferator activated receptor agonist—Saroglitazar in diabetic dyslipidemia and non-alcoholic fatty liver disease: integrated analysis of the real world evidence
- (2019) Upendra Kaul et al. Cardiovascular Diabetology
- The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
- (2019) Jean-Charles Fruchart et al. Cardiovascular Diabetology
- Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes
- (2019) S. Smati et al. DIABETES & METABOLISM
- Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial
- (2019) Fernando Bril et al. DIABETES CARE
- Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility
- (2019) Federica Gilardi et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The dual PPAR-α/γ agonist saroglitazar ameliorates thioacetamide-induced liver fibrosis in rats through regulating leptin
- (2019) Mirhan N. Makled et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
- (2019) Anton Iershov et al. Nature Communications
- Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH
- (2019) Jonathan D. Roth et al. Scientific Reports
- Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease
- (2019) Dimitrios A. Koutoukidis et al. JAMA Internal Medicine
- Serum Vitamin E Levels of Adults with Nonalcoholic Fatty Liver Disease: An Inverse Relationship with All-Cause Mortality in Non-Diabetic but Not in Pre-Diabetic or Diabetic Subjects
- (2019) Peiling Tsou et al. Journal of Clinical Medicine
- Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner
- (2019) Zhuo Wei et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool
- (2019) Stefan Jordan et al. CELL
- Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH)
- (2019) Menso J. Westerouen Van Meeteren et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue
- (2019) Magdalene K. Montgomery et al. FASEB JOURNAL
- Association between Vitamin D Status and Non-Alcoholic Fatty Liver Disease: A Population-Based Study
- (2019) Shiying LIU et al. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
- Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet
- (2019) Mariana de Mendonça et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Non-alcoholic fatty liver disease in adults: Current concepts in etiology, outcomes and management
- (2019) Thomas Marjot et al. ENDOCRINE REVIEWS
- Exposure to Persistent Organic Pollutants (POPs) and Their Relationship to Hepatic Fat and Insulin Insensitivity among Asian Indian Immigrants in the United States
- (2019) Michele A. La Merrill et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- The Potential of the FSP1cre-Pparb/d−/− Mouse Model for Studying Juvenile NAFLD
- (2019) Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination
- (2019) Yamashita et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate
- (2019) Yusuke Sasaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- β-Klotho gene variation is associated with liver damage in children with NAFLD
- (2019) Paola Dongiovanni et al. JOURNAL OF HEPATOLOGY
- Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2019) Stephen A Harrison et al. LANCET
- Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology
- (2019) Mohammed Eslam et al. Nature Reviews Gastroenterology & Hepatology
- Are Lifestyle Therapies Effective for NAFLD Treatment?
- (2019) Nermeen N. El-Agroudy et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
- (2019) Robert N Helsley et al. eLife
- The Association between SOCS1−1656G>A Polymorphism, Insulin Resistance and Obesity in Nonalcoholic Fatty Liver Disease (NAFLD) Patients
- (2019) Agnieszka Kempinska-Podhorodecka et al. Journal of Clinical Medicine
- Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
- (2019) Zobair M Younossi et al. LANCET
- Systematic Review with Meta-Analysis: The Effects of Probiotics in Nonalcoholic Fatty Liver Disease
- (2019) Meng-Wei Xiao et al. Gastroenterology Research and Practice
- Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered
- (2019) Maria Corina Plaz Torres et al. Nutrients
- Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
- (2019) Naba Saeed et al. Nutrients
- Effect of a Dual PPAR α/γ agonist on Insulin Sensitivity in Patients of Type 2 Diabetes with Hypertriglyceridemia- Randomized double-blind placebo-controlled trial
- (2019) Nimisha Jain et al. Scientific Reports
- Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
- (2019) Joost Boeckmans et al. Cells
- Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis
- (2018) Srilaxmi Kalavalapalli et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
- (2018) Adil Mardinoglu et al. Cell Metabolism
- Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis
- (2018) Nicole E. Rich et al. Clinical Gastroenterology and Hepatology
- Response to Pioglitazone in Patients With Nonalcoholic Steatohepatitis With vs Without Type 2 Diabetes
- (2018) Fernando Bril et al. Clinical Gastroenterology and Hepatology
- Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial
- (2018) Eiichi Araki et al. DIABETES CARE
- Molecular actions of PPARα in lipid metabolism and inflammation
- (2018) Nadia Bougarne et al. ENDOCRINE REVIEWS
- Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue
- (2018) Durgesh Kumar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study
- (2018) Alina M. Allen et al. HEPATOLOGY
- Insights into the Role of PPARβ/δ in NAFLD
- (2018) Jiapeng Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Functional Regulation of PPARs through Post-Translational Modifications
- (2018) Reinhard Brunmeir et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice
- (2018) Masami Sairyo et al. Journal of Atherosclerosis and Thrombosis
- Efficacy and Safety of Pemafibrate Versus Fenofibrate in Patients with High Triglyceride and Low HDL Cholesterol Levels: A Multicenter, Placebo-Controlled, Double-Blind, Randomized Trial
- (2018) Hidenori Arai et al. Journal of Atherosclerosis and Thrombosis
- Fructose metabolism and metabolic disease
- (2018) Sarah A. Hannou et al. JOURNAL OF CLINICAL INVESTIGATION
- Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial
- (2018) Shun Ishibashi et al. Journal of Clinical Lipidology
- Genetics and epigenetics of NAFLD and NASH: Clinical impact
- (2018) Mohammed Eslam et al. JOURNAL OF HEPATOLOGY
- Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
- (2018) Thomas Jensen et al. JOURNAL OF HEPATOLOGY
- Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?
- (2018) Amedeo Lonardo et al. JOURNAL OF HEPATOLOGY
- Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice
- (2018) Albert G. Linden et al. JOURNAL OF LIPID RESEARCH
- Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate
- (2018) Benaïssa Boubia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization
- (2018) Qiong A. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- Insights into the role of hepatocyte PPARα activity in response to fasting
- (2018) Marion Régnier et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice
- (2018) Flavia Maria Silva-Veiga et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women
- (2018) Lesley Hoyles et al. NATURE MEDICINE
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
- (2018) Liping Zhao et al. SCIENCE
- Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis
- (2018) Kirstine S Tølbøl et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Practical Dietary Recommendations for the Prevention and Management of Nonalcoholic Fatty Liver Disease in Adults
- (2018) Elena S George et al. Advances in Nutrition
- Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase
- (2018) David Lasar et al. Cell Reports
- Pioglitazone and bladder cancer risk: a systematic review and meta-analysis
- (2018) Huilin Tang et al. Cancer Medicine
- A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis
- (2018) Marina Kawaguchi-Suzuki et al. Frontiers in Pharmacology
- Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha
- (2018) Guolin Li et al. Molecular Metabolism
- The Peroxisome Proliferator-Activated Receptor α is dispensable for cold-induced adipose tissue browning in mice
- (2018) Merel Defour et al. Molecular Metabolism
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
- (2018) Mohammad Zarei et al. Molecular Metabolism
- The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice
- (2018) Masaya Araki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study
- (2018) Jan Oscarsson et al. Journal of Clinical Lipidology
- Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease
- (2018) Vincent Wai-Sun Wong et al. JOURNAL OF HEPATOLOGY
- Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice
- (2018) Chad N. Brocker et al. JOURNAL OF LIPID RESEARCH
- Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease
- (2018) Jian-Hui Yan et al. MEDICINE
- Should patients with NAFLD/NASH be surveyed for HCC?
- (2018) Maria Reig et al. TRANSPLANTATION
- Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression
- (2018) Hwa Young Ahn et al. PPAR Research
- Complementary intestinal mucosa and microbiota responses to caloric restriction
- (2018) Kalina Duszka et al. Scientific Reports
- The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity
- (2018) Aniket Nikam et al. Scientific Reports
- Effect of pioglitazone on bone mineral density in patients with nonalcoholic steatohepatitis: A 36-month clinical trial
- (2018) Paola Portillo-Sanchez et al. Journal of Diabetes
- Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study
- (2018) Aruna D. Pradhan et al. AMERICAN HEART JOURNAL
- A systematic review of observational studies of the association between pioglitazone use and bladder cancer
- (2018) E. Ripamonti et al. DIABETIC MEDICINE
- The role of the microbiome in NAFLD and NASH
- (2018) Aleksandra A Kolodziejczyk et al. EMBO Molecular Medicine
- Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease
- (2018) Fasiha Kanwal et al. GASTROENTEROLOGY
- Improvements in Histologic Features and Diagnosis associated with Improvement in Fibrosis in NASH : Results from the NASH Clinical Research Network Treatment Trials
- (2018) Elizabeth M Brunt et al. HEPATOLOGY
- Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH
- (2018) Geoff Farrell et al. HEPATOLOGY
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- Role of vitamin E in nonalcoholic fatty liver disease
- (2018) Mayumi Nagashimada et al. IUBMB LIFE
- Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis
- (2018) Bubu A. Banini et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues
- (2018) Pierre-Gilles Blanchard et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Bariatric surgery improves nonalcoholic fatty liver disease: a contemporary systematic review and meta-analysis
- (2018) Tannous K. Fakhry et al. Surgery for Obesity and Related Diseases
- Gemfibrozil reduces lipid accumulation in SMMC‑7721 cells via the involvement of PPARα and SREBP1
- (2018) Xiaonan Zhang et al. Experimental and Therapeutic Medicine
- Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
- (2018) Jessie Qiaoyi Liang et al. Nature Communications
- Benefits and risks of the treatment with fibrates––a comprehensive summary
- (2018) Bogusław Okopień et al. Expert Review of Clinical Pharmacology
- Comparison of fenofibrate and pioglitazone effects on patients with nonalcoholic fatty liver disease
- (2017) Malek Yaghoubi et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes
- (2017) Mariya Markova et al. GASTROENTEROLOGY
- Inflammation is independent of steatosis in a murine model of steatohepatitis
- (2017) Wei Wang et al. HEPATOLOGY
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
- (2017) Soumik BasuRay et al. HEPATOLOGY
- Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance
- (2017) Melania Gaggini et al. HEPATOLOGY
- The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
- (2017) Naga Chalasani et al. HEPATOLOGY
- Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis
- (2017) Nicole Ehrhardt et al. HUMAN MOLECULAR GENETICS
- A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease
- (2017) Paola Dongiovanni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription
- (2017) Cecilia Patitucci et al. JOURNAL OF CLINICAL INVESTIGATION
- Distinct but complementary contributions of PPAR isotypes to energy homeostasis
- (2017) Vanessa Dubois et al. JOURNAL OF CLINICAL INVESTIGATION
- Response to: Comment to “EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease”
- (2017) Giulio Marchesini et al. JOURNAL OF HEPATOLOGY
- Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review
- (2017) Ryuki Hashida et al. JOURNAL OF HEPATOLOGY
- Treatment of NAFLD with diet, physical activity and exercise
- (2017) Manuel Romero-Gómez et al. JOURNAL OF HEPATOLOGY
- PPARα protects against trans -fatty-acid-containing diet-induced steatohepatitis
- (2017) Xiao Hu et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice
- (2017) Kenta Takei et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models
- (2017) Mukul R. Jain et al. LIVER INTERNATIONAL
- Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
- (2017) Wenjie Dai et al. MEDICINE
- Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis
- (2017) Christina N Katsagoni et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Personal model‐assisted identification of NAD + and glutathione metabolism as intervention target in NAFLD
- (2017) Adil Mardinoglu et al. Molecular Systems Biology
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- Targeting nuclear receptors for the treatment of fatty liver disease
- (2017) Naoki Tanaka et al. PHARMACOLOGY & THERAPEUTICS
- Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
- (2017) Sulin Cheng et al. Scientific Reports
- Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients
- (2017) Franck Chiappini et al. Scientific Reports
- Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease
- (2017) Wenjing Luo et al. Scientific Reports
- Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis
- (2017) Giovanni Musso et al. JAMA Internal Medicine
- High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease
- (2017) Sechang Oh et al. Scientific Reports
- Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis
- (2017) Yasushi Honda et al. Scientific Reports
- Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia
- (2017) Marcela Doktorova et al. Scientific Reports
- MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
- (2017) Benedetta Donati et al. Scientific Reports
- Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis
- (2017) Pi-Jung Hsiao et al. Scientific Reports
- Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus
- (2016) Kenneth Cusi et al. ANNALS OF INTERNAL MEDICINE
- Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
- (2016) Nadira Ruzehaji et al. ANNALS OF THE RHEUMATIC DISEASES
- Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease
- (2016) Joel T. Haas et al. Annual Review of Physiology
- The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis
- (2016) Nathalie Hennuyer et al. ATHEROSCLEROSIS
- Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.
- (2016) Matthew C. Cave et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis
- (2016) N A Smart et al. BRITISH JOURNAL OF SPORTS MEDICINE
- Body Fat Distribution and Risk of Incident and Regressed Nonalcoholic Fatty Liver Disease
- (2016) Donghee Kim et al. Clinical Gastroenterology and Hepatology
- Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation
- (2016) Lutgarda Bozzetto et al. DIABETOLOGIA
- Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
- (2016) Samir Softic et al. DIGESTIVE DISEASES AND SCIENCES
- Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening
- (2016) Vlad Ratziu et al. GASTROENTEROLOGY
- The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
- (2016) Rosellina Margherita Mancina et al. GASTROENTEROLOGY
- Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
- (2016) Alexandra Montagner et al. GUT
- Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
- (2016) Zobair M. Younossi et al. HEPATOLOGY
- The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
- (2016) Jérôme Boursier et al. HEPATOLOGY
- Non-Alcoholic Fatty Liver Disease and Extra-Hepatic Cancers
- (2016) Claudia Sanna et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Body Mass Index and Risk of Nonalcoholic Fatty Liver Disease: Two Electronic Health Record Prospective Studies
- (2016) A. Katrina Loomis et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice
- (2016) Abigail Wolf Greenstein et al. JOURNAL OF ENDOCRINOLOGY
- The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
- (2016) Matthew James Armstrong et al. LANCET
- Lipid phenotypes in patients with nonalcoholic fatty liver disease
- (2016) Tingting Du et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Non-alcoholic fatty liver disease and dyslipidemia: An update
- (2016) Niki Katsiki et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The role of the gut microbiota in NAFLD
- (2016) Christopher Leung et al. Nature Reviews Gastroenterology & Hepatology
- Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies
- (2016) L. Li et al. Obesity Reviews
- Effectiveness of exercise in hepatic fat mobilization in non-alcoholic fatty liver disease: Systematic review
- (2016) Pegah Golabi et al. WORLD JOURNAL OF GASTROENTEROLOGY
- White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
- (2016) V. Barquissau et al. Molecular Metabolism
- Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy
- (2016) Fuyang Zhang et al. EBioMedicine
- Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
- (2016) Alexandra Montagner et al. Scientific Reports
- Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation
- (2015) Syeda H. Afroze et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis
- (2015) Chrysi Koliaki et al. Cell Metabolism
- Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies
- (2015) Siddharth Singh et al. Clinical Gastroenterology and Hepatology
- Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial
- (2015) K. Hallsworth et al. CLINICAL SCIENCE
- Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
- (2015) Amedeo Lonardo et al. DIGESTIVE AND LIVER DISEASE
- TM6SF2: Catch-22 in the Fight Against Nonalcoholic Fatty Liver Disease and Cardiovascular Disease?
- (2015) Bratati Kahali et al. GASTROENTEROLOGY
- Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis
- (2015) Eduardo Vilar-Gomez et al. GASTROENTEROLOGY
- Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
- (2015) Paul Angulo et al. GASTROENTEROLOGY
- Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients
- (2015) Guillaume Lassailly et al. GASTROENTEROLOGY
- Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
- (2015) Paola Dongiovanni et al. HEPATOLOGY
- Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease
- (2015) Sahar Mohamed El-Haggar et al. Hepatology International
- Effect of Chronic Pioglitazone Treatment on Hepatic Gene Expression Profile in Obese C57BL/6J Mice
- (2015) Chunming Jia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver
- (2015) Sana Raza-Iqbal et al. Journal of Atherosclerosis and Thrombosis
- High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels
- (2015) Paola Portillo-Sanchez et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
- (2015) Stuart McPherson et al. JOURNAL OF HEPATOLOGY
- PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis
- (2015) Sven Francque et al. JOURNAL OF HEPATOLOGY
- Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial
- (2015) Curtis K. Argo et al. JOURNAL OF HEPATOLOGY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Visceral Obesity Predicts Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
- (2015) Su Jong Yu et al. MEDICINE
- Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease
- (2015) Sheng-Jie Wu et al. MEDICINE
- Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure UponPparα Deficiency
- (2015) Michal Pawlak et al. MOLECULAR ENDOCRINOLOGY
- PPARαIs Required for PPARδAction in Regulation of Body Weight and Hepatic Steatosis in Mice
- (2015) Wojciech G. Garbacz et al. PPAR Research
- Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
- (2015) Ling Chen et al. Oncotarget
- NASH resolution is associated with improvements in HDL and triglyceride levels but not improvement in LDL or non-HDL-C levels
- (2014) K. E. Corey et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
- (2014) April D. Lake et al. AMINO ACIDS
- Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes
- (2014) Raymond E. Soccio et al. Cell Metabolism
- Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers
- (2014) Sebastian C. Hasenfuss et al. Cell Metabolism
- The First Approved Agent in the Glitazar’s Class: Saroglitazar
- (2014) Ritesh Agrawal CURRENT DRUG TARGETS
- The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
- (2014) Michal Pawlak et al. HEPATOLOGY
- PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
- (2014) Carlo Pirazzi et al. HUMAN MOLECULAR GENETICS
- Bariatric Surgery Improves Histological Features of Nonalcoholic Fatty Liver Disease and Liver Fibrosis
- (2014) Andrew A. Taitano et al. JOURNAL OF GASTROINTESTINAL SURGERY
- PPARδ activation attenuates hepatic steatosis inLdlr−/−mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
- (2014) Lazar A. Bojic et al. JOURNAL OF LIPID RESEARCH
- High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids
- (2014) Sonia C. Garcia Caraballo et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Nutrient-sensing nuclear receptors coordinate autophagy
- (2014) Jae Man Lee et al. NATURE
- Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
- (2014) Oddgeir L Holmen et al. NATURE GENETICS
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review
- (2014) Bogna Grygiel-Górniak Nutrition Journal
- Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents
- (2014) Laila Al-Eryani et al. TOXICOLOGIC PATHOLOGY
- Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial
- (2014) Shira Zelber-Sagi WORLD JOURNAL OF GASTROENTEROLOGY
- TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
- (2014) Yang-Lin Liu et al. Nature Communications
- Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease
- (2014) Adil Mardinoglu et al. Nature Communications
- Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
- (2013) Piero Pingitore et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Prevention and reversal of hepatic steatosis with a high-protein diet in mice
- (2013) Sonia C. Garcia-Caraballo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease
- (2013) Meropi D. Kontogianni et al. CLINICAL NUTRITION
- The Role of Diet and Nutritional Intervention for the Management of Patients with NAFLD
- (2013) Francisco Barrera et al. Clinics in Liver Disease
- Dual Peroxisome Proliferator-Activated Receptor / Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects
- (2013) B. Cariou et al. DIABETES CARE
- A Multicenter, Prospective, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Saroglitazar 2 and 4 mg Compared with Placebo in Type 2 Diabetes Mellitus Patients Having Hypertriglyceridemia Not Controlled with Atorvastatin Therapy (PRESS VI)
- (2013) Rajendrakumar H. Jani et al. Diabetes Technology & Therapeutics
- Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
- (2013) Jennifer E. Lambert et al. GASTROENTEROLOGY
- Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
- (2013) Bart Staels et al. HEPATOLOGY
- Hepatic molecular effects of rosiglitazone in human non-alcoholic steatohepatitis suggest long-term pro-inflammatory damage
- (2013) Maud Lemoine et al. HEPATOLOGY RESEARCH
- Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups
- (2013) Mark M Smits et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease
- (2013) Marno C. Ryan et al. JOURNAL OF HEPATOLOGY
- Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells
- (2013) Eva Morán-Salvador et al. JOURNAL OF HEPATOLOGY
- Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor
- (2013) Simon Ducheix et al. JOURNAL OF HEPATOLOGY
- A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use
- (2013) Sihao Liu et al. NATURE
- Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR
- (2013) F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
- (2012) Paul A. Dutchak et al. CELL
- Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients
- (2012) L. Bozzetto et al. DIABETES CARE
- Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism
- (2012) Mi Young Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
- (2012) Rohit Loomba et al. HEPATOLOGY
- Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
- (2012) John Zhong Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis
- (2012) Shelley E. Keating et al. JOURNAL OF HEPATOLOGY
- PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats
- (2012) Aina Rodríguez-Vilarrupla et al. JOURNAL OF HEPATOLOGY
- PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
- (2012) Daniela Cipolletta et al. NATURE
- A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
- (2012) Johan W. Jonker et al. NATURE
- Dietary Protein Affects Gene Expression and Prevents Lipid Accumulation in the Liver in Mice
- (2012) Jessica Schwarz et al. PLoS One
- Protection from liver fibrosis by a peroxisome proliferator-activated receptor agonist
- (2012) K. Iwaisako et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism
- (2012) Q. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PPARs at the crossroads of lipid signaling and inflammation
- (2012) Walter Wahli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- PPARγ contributes to PKM2 and HK2 expression in fatty liver
- (2012) Ganna Panasyuk et al. Nature Communications
- GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
- (2012) Radina Kostadinova et al. Cell and Bioscience
- Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
- (2011) E. Boettcher et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Endocrine Disruptors: From Endocrine to Metabolic Disruption
- (2011) Cristina Casals-Casas et al. Annual Review of Physiology
- Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
- (2011) Eva Morán-Salvador et al. FASEB JOURNAL
- Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
- (2011) K. Hallsworth et al. GUT
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
- (2011) Nicola Santoro et al. HEPATOLOGY
- Low doses of bisphenol a induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver
- (2011) Alice Marmugi et al. HEPATOLOGY
- Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents
- (2011) Joel E. Lavine JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Vitamin E and the Risk of Prostate Cancer
- (2011) Eric A. Klein et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Influence of Fatty Liver on Plasma Small, Dense LDL- Cholesterol in Subjects with and without Metabolic Syndrome
- (2011) Ikumi Sugino et al. Journal of Atherosclerosis and Thrombosis
- Human SREBP1c Expression in Liver Is Directly Regulated by Peroxisome Proliferator-activated Receptor α (PPARα)
- (2011) Ana Fernández-Alvarez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat
- (2011) Elayne Hondares et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peroxisome proliferator-activated receptor-α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis
- (2011) Claire Z Larter et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver
- (2011) Mohamed A. Abdelmegeed et al. JOURNAL OF NUTRITION
- Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors
- (2011) Nathalie C. Leite et al. LIVER INTERNATIONAL
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators
- (2010) Jennifer G. Duncan et al. CIRCULATION
- Pioglitazone: side effect and safety profile
- (2010) Priya Shah et al. Expert Opinion On Drug Safety
- Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
- (2010) Manal F. Abdelmalek et al. HEPATOLOGY
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
- (2010) Herbert Tilg et al. HEPATOLOGY
- Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation
- (2010) Sihao Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Fenofibrate and Niacin on Intrahepatic Triglyceride Content, Very Low-Density Lipoprotein Kinetics, and Insulin Action in Obese Subjects with Nonalcoholic Fatty Liver Disease
- (2010) Elisa Fabbrini et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease
- (2010) Claudia O. Zein et al. JOURNAL OF HEPATOLOGY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Peroxisome Proliferator-Activated Receptor Alpha Target Genes
- (2010) Maryam Rakhshandehroo et al. PPAR Research
- Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
- (2009) Aparna Purushotham et al. Cell Metabolism
- Adiponectin Expression Is Induced by Vitamin E via a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism
- (2009) Jean-François Landrier et al. ENDOCRINOLOGY
- Peroxisome Proliferator-Activated Receptor-α Control of Lipid and Glucose Metabolism in Human White Adipocytes
- (2009) Carole Ribet et al. ENDOCRINOLOGY
- Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease
- (2009) Philippe Mathurin et al. GASTROENTEROLOGY
- Pioglitazone: More than just an insulin sensitizer
- (2009) Mark J. Czaja HEPATOLOGY
- Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the united states population
- (2009) George N. Ioannou et al. HEPATOLOGY
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- Gemfibrozil, stretching arms beyond lipid lowering
- (2009) Avik Roy et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
- (2009) Nicolas Leuenberger et al. JOURNAL OF CLINICAL INVESTIGATION
- Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver
- (2009) Linda M. Sanderson et al. PHYSIOLOGICAL GENOMICS
- Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27
- (2008) Kimihiko Matsusue et al. Cell Metabolism
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- (2008) Cecilia Gälman et al. Cell Metabolism
- Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
- (2008) Justin I. Odegaard et al. Cell Metabolism
- Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
- (2008) Naga P. Chalasani et al. Contemporary Clinical Trials
- A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease
- (2008) C. Fernández-Miranda et al. DIGESTIVE AND LIVER DISEASE
- Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial
- (2008) Vlad Ratziu et al. GASTROENTEROLOGY
- Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis
- (2008) Guruprasad P. Aithal et al. GASTROENTEROLOGY
- Peroxisome proliferator-activated receptor-δ induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
- (2008) Xiaomei Qin et al. HEPATOLOGY
- Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
- (2008) David van der Poorten et al. HEPATOLOGY
- Fructose consumption as a risk factor for non-alcoholic fatty liver disease
- (2008) Xiaosen Ouyang et al. JOURNAL OF HEPATOLOGY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice
- (2008) Yue-Min Nan et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression
- (2008) Weiwei Shan et al. TOXICOLOGICAL SCIENCES
- Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism
- (2007) Sander Kersten PPAR Research
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