Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice

(2016) Rhonda D. Kineman et al.   ENDOCRINOLOGY

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice

(2016) Soona Shin et al.   HEPATOLOGY

Mogat1deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

(2016) Anil K. Agarwal et al.   JOURNAL OF LIPID RESEARCH

Impact of high-fat diet on the proteome of mouse liver

(2016) Outhiriaradjou Benard et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice

(2016) Olga Horakova et al.   PLoS One

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis

(2016) Jung Hwan Yu et al.   Scientific Reports

Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation

(2015) Jung Hwan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of hepatic lipase activity by sphingomyelin in plasma lipoproteins

(2015) Peng Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

(2015) Jose Cordoba-Chacon et al.   DIABETES

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass

(2015) Jose Cordoba-Chacon et al.   GROWTH HORMONE & IGF RESEARCH

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

(2015) Pär Steneberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

(2015) Nicole M Ashpole et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis

(2014) Joseph J Lee et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice

(2014) Jose Cordoba-Chacon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

(2014) A. M. Hall et al.   DIABETES

Long- But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of β-Cell Function, Which Cannot Be Accounted for by Changes in β-Cell Mass

(2014) Jose Cordoba-Chacon et al.   ENDOCRINOLOGY

Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice

(2014) Kimihiko Matsusue et al.   FEBS LETTERS

Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities but Not Inflammation and Injury in Mice

(2014) Nisreen Soufi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

(2014) Joao A. G. Duarte et al.   JOURNAL OF LIPID RESEARCH

Liver transplantation and non-alcoholic fatty liver disease

(2014) Petros Zezos   WORLD JOURNAL OF GASTROENTEROLOGY

Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer

(2013) Abigale Lade et al.   CURRENT OPINION IN ONCOLOGY

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis inob/obmice

(2013) Fatiha Nassir et al.   JOURNAL OF LIPID RESEARCH

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic Fatty Acid Trafficking: Multiple Forks in the Road

(2013) Douglas G. Mashek   Advances in Nutrition

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

(2012) Ksenia Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

(2012) Günther Silbernagel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling

(2012) Sascha Obrowsky et al.   JOURNAL OF LIPID RESEARCH

Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver

(2012) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Nuclear receptor PPAR -regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

(2012) Y. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

(2011) Rosalind A. Coleman et al.   CHEMICAL REVIEWS

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008

(2011) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

(2011) Liang Bai et al.   HEPATOLOGY

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice

(2010) Anisha A. Gupte et al.   HEPATOLOGY

An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat

(2010) Tomomi Yamazaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Peroxisome proliferator-activated receptor-γ regulates the expression and function of very-low-density lipoprotein receptor

(2009) Huan Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

(2009) Víctor A. Cortés et al.   Cell Metabolism

Persistent Diet-Induced Obesity in Male C57BL/6 Mice Resulting from Temporary Obesigenic Diets

(2009) Juen Guo et al.   PLoS One

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

(2008) Vlad Ratziu et al.   GASTROENTEROLOGY

A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes

(2008) Carine Beysen et al.   JOURNAL OF LIPID RESEARCH

Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice

(2008) Yue-Min Nan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY