PPARα and NCOR/SMRT corepressor network in liver metabolic regulation

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

(2020) Lise Van Wyngene et al.   EMBO Molecular Medicine

Hepatic PPARα is critical in the metabolic adaptation to sepsis

(2019) Réjane Paumelle et al.   JOURNAL OF HEPATOLOGY

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

(2019) Ning Liang et al.   Nature Communications

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

(2019) Meredith A Sommars et al.   eLife

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

(2019) Anton Iershov et al.   Nature Communications

Autophagy regulates lipid metabolism through selective turnover of NCoR1

(2019) Tetsuya Saito et al.   Nature Communications

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action

(2019) Hiroaki Shimizu et al.   PLoS One

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

(2019) Nadia Bougarne et al.   Frontiers in Immunology

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

(2019) Fabiana Quagliarini et al.   MOLECULAR CELL

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

(2019) Mercedes Dávalos-Salas et al.   Nature Communications

New opportunities for kinase drug repurposing and target discovery

(2018) Stefan Knapp   BRITISH JOURNAL OF CANCER

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) Nadia Bougarne et al.   ENDOCRINE REVIEWS

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

(2018) Qing Ou-Yang et al.   HEPATOLOGY

G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages

(2018) Zhiqiang Huang et al.   FASEB JOURNAL

The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development

(2018) Fan Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond

(2018) Pallavi R. Devchand et al.   Frontiers in Pharmacology

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

(2017) Rasmus Siersbæk et al.   MOLECULAR CELL

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

(2016) Swetha Rudraiah et al.   Annual Review of Pharmacology and Toxicology

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

(2016) Rongrong Fan et al.   NATURE MEDICINE

Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes

(2016) Hisham Mohammed et al.   Nature Protocols

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

(2016) Gianpaolo Rando et al.   eLife

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

(2015) Young Suk Jo et al.   HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Transcriptional Coregulators: Fine-Tuning Metabolism

(2014) Laurent Mouchiroud et al.   Cell Metabolism

Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway

(2014) Inna Astapova et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HDAC3 promotes ligand-independent PPARγ activation by protein acetylation

(2014) Xiaoting Jiang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

NCoR1 and SMRT Play Unique Roles in Thyroid Hormone ActionIn Vivo

(2014) Hiroaki Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

GPS2/KDM4A Pioneering Activity Regulates Promoter-Specific Recruitment of PPARγ

(2014) M. Dafne Cardamone et al.   Cell Reports

Changes in Nucleosome Occupancy Associated with Metabolic Alterations in Aged Mammalian Liver

(2014) Irina M. Bochkis et al.   Cell Reports

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

(2013) Pingping Li et al.   CELL

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Improving Insulin Sensitivity With HDAC Inhibitor

(2013) J. Ye   DIABETES

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

(2013) A. Mottis et al.   GENES & DEVELOPMENT

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo

(2013) Seo-Hee You et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

(2012) H. Li et al.   DIABETES

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation

(2012) Amine Toubal et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ–inducible protein 10 in a casein kinase 2–dependent manner

(2012) Jung-Yoon Yoo et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia

(2011) Philipp Kulozik et al.   Cell Metabolism

S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

(2011) KyeongJin Kim et al.   HEPATOLOGY

Nuclear hormone receptor co-repressors: Structure and function

(2011) Peter J. Watson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis

(2011) Inna Astapova et al.   MOLECULAR ENDOCRINOLOGY

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

(2011) Jasmeen Oberoi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

(2011) S. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)

(2011) L. Fozzatti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Nuclear Receptor Corepressor SMRT Regulates Mitochondrial Oxidative Metabolism and Mediates Aging-Related Metabolic Deterioration

(2010) Shannon M. Reilly et al.   Cell Metabolism

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR  in the hepatic acute phase response

(2010) N. Venteclef et al.   GENES & DEVELOPMENT

The Interaction between Nuclear Receptor Corepressor and Histone Deacetylase 3 Regulates Both Positive and Negative Thyroid Hormone Actionin Vivo

(2010) Seo-Hee You et al.   MOLECULAR ENDOCRINOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

SUMOylation of Human Peroxisome Proliferator-activated Receptor α Inhibits Its Trans-activity through the Recruitment of the Nuclear Corepressor NCoR

(2009) Benoit Pourcet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

(2009) Nicolas Leuenberger et al.   JOURNAL OF CLINICAL INVESTIGATION

GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus

(2009) Tomas Jakobsson et al.   MOLECULAR CELL

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

A Natural Polymorphism in Peroxisome Proliferator-Activated Receptor-α Hinge Region Attenuates Transcription due to Defective Release of Nuclear Receptor Corepressor from Chromatin

(2008) Mei Hui Liu et al.   MOLECULAR ENDOCRINOLOGY

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

(2008) R. R. Nofsinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

(2008) I. Astapova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA