Interactions between Host PPARs and Gut Microbiota in Health and Disease

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

(2018) Adil Mardinoglu et al.   Cell Metabolism

PPARγ activation mitigates glucocorticoid receptor-induced excessive lipolysis in adipocytes via homeostatic crosstalk

(2018) Arif U. Hasan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice

(2018) P Lu et al.   Mucosal Immunology

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Associations between Gut Microbiota and Common Luminal Intestinal Parasites

(2018) Christen Rune Stensvold et al.   TRENDS IN PARASITOLOGY

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity

(2018) Patricia Corrales et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

(2018) Keith A. Sharkey et al.   Nature Reviews Gastroenterology & Hepatology

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Commensal bacteria make GPCR ligands that mimic human signalling molecules

(2017) Louis J. Cohen et al.   NATURE

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response

(2017) Qian Chen et al.   Nutrients

Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis

(2017) Chien-Chao Chiu et al.   Nutrients

Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver

(2017) Claudia C. Alves et al.   Frontiers in Microbiology

Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD

(2017) Irene Pierantonelli et al.   Scientific Reports

The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review

(2016) Erigene Rutayisire et al.   BMC GASTROENTEROLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine

(2016) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

(2016) Kimberly A. Krautkramer et al.   MOLECULAR CELL

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

(2016) Barbara Gross et al.   Nature Reviews Endocrinology

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

(2016) Julie Tomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis

(2015) Won Sohn et al.   DIGESTIVE DISEASES AND SCIENCES

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

(2015) Licio A. Velloso et al.   ENDOCRINE REVIEWS

Probiotic Lactobacillus casei Zhang reduces pro-inflammatory cytokine production and hepatic inflammation in a rat model of acute liver failure

(2015) Yuzhen Wang et al.   EUROPEAN JOURNAL OF NUTRITION

Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice

(2015) Raffaele Simeoli et al.   JOURNAL OF NUTRITION

Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

(2015) Arif U. Hasan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Commensal Streptococcus salivarius Modulates PPARγ Transcriptional Activity in Human Intestinal Epithelial Cells

(2015) Benoît Couvigny et al.   PLoS One

Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver

(2015) Lu Mei et al.   PLoS One

Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity

(2014) Arif U Hasan et al.   HYPERTENSION RESEARCH

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Probiotic Mix VSL#3 Is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis

(2014) Houssam E. Mardini et al.   INFLAMMATORY BOWEL DISEASES

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity

(2014) M. Li et al.   Beneficial Microbes

Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway

(2014) Parag Kundu et al.   PLoS Pathogens

Obesity and NAFLD

(2013) Ajay Duseja et al.   Clinics in Liver Disease

Diversity of human small intestinalStreptococcusandVeillonellapopulations

(2013) Bartholomeus van den Bogert et al.   FEMS MICROBIOLOGY ECOLOGY

Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice

(2013) Yundong Sun et al.   GASTROENTEROLOGY

Meta-analyses of studies of the human microbiota

(2013) C. A. Lozupone et al.   GENOME RESEARCH

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Species and strain specificity of Lactobacillus probiotics effect on weight regulation

(2013) Matthieu Million et al.   MICROBIAL PATHOGENESIS

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats

(2013) Feng-Ching Hsieh et al.   Nutrition & Metabolism

Prenatal Methyl-Donor Supplementation Augments Colitis in Young Adult Mice

(2013) Sabina A. Mir et al.   PLoS One

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbiota Regulate Intestinal Absorption and Metabolism of Fatty Acids in the Zebrafish

(2012) Ivana Semova et al.   Cell Host & Microbe

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

(2012) Michael H. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactobacillus casei Shirota protects from fructose-induced liver steatosis: A mouse model

(2012) Sabine Wagnerberger et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals

(2012) Matthieu Million et al.   MICROBIAL PATHOGENESIS

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

(2012) Hamed Laroui et al.   PLoS One

Role of Toll Like Receptors in Irritable Bowel Syndrome: Differential Mucosal Immune Activation According to the Disease Subtype

(2012) Liliana Belmonte et al.   PLoS One

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

(2012) Andrea Mencarelli et al.   PLoS One

Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism

(2012) Josep Bassaganya-Riera et al.   PLoS One

Human Microbiome in Health and Disease

(2011) Kathryn J. Pflughoeft et al.   Annual Review of Pathology-Mechanisms of Disease

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome

(2011) Mirjana Rajilić–Stojanović et al.   GASTROENTEROLOGY

Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome

(2011) Delphine M. Saulnier et al.   GASTROENTEROLOGY

B-Group vitamin production by lactic acid bacteria - current knowledge and potential applications

(2011) J.G. LeBlanc et al.   JOURNAL OF APPLIED MICROBIOLOGY

Prebiotic Oligosaccharides Reduce Proinflammatory Cytokines in Intestinal Caco-2 Cells via Activation of PPARγ and Peptidoglycan Recognition Protein 3

(2011) Marwa Zenhom et al.   JOURNAL OF NUTRITION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

(2011) Naruhisa Ota et al.   NATURE IMMUNOLOGY

Fecal microbiota transplantation and emerging applications

(2011) Thomas J. Borody et al.   Nature Reviews Gastroenterology & Hepatology

PPARγ-dependent peptidoglycan recognition protein 3 (PGlyRP3) expression regulates proinflammatory cytokines by microbial and dietary fatty acids

(2010) Marwa Zenhom et al.   IMMUNOBIOLOGY

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

(2010) L. Peyrin-Biroulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome

(2010) Erja Malinen   WORLD JOURNAL OF GASTROENTEROLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

(2009) P. A. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Enterococcus faecalis from newborn babies regulate endogenous PPAR  activity and IL-10 levels in colonic epithelial cells

(2008) A. Are et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA