Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

Hepatic Monoacylglycerol Acyltransferase 1 is Induced by Prolonged Food Deprivation to Modulate the Hepatic Fasting Response

(2019) Andrew J. Lutkewitte et al.   JOURNAL OF LIPID RESEARCH

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential

(2019) Jean-Charles Fruchart et al.   Cardiovascular Diabetology

Chemokine ligand 20 (CCL20) expression increases with NAFLD stage and hepatic stellate cell activation and is regulated by miR-590-5p

(2019) Amanda Hanson et al.   CYTOKINE

Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate

(2019) Yusuke Sasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adaptive immunity: an emerging player in the progression of NAFLD

(2019) Salvatore Sutti et al.   Nature Reviews Gastroenterology & Hepatology

CIDE family proteins control lipid homeostasis and the development of metabolic diseases

(2019) Feng‐Jung Chen et al.   TRAFFIC

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights

(2018) Tadayoshi Karasawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis

(2018) Kia M. Peters et al.   CURRENT OPINION IN LIPIDOLOGY

Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial

(2018) Shun Ishibashi et al.   Journal of Clinical Lipidology

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis

(2018) Byeong-Moo Kim et al.   Scientific Reports

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

(2017) Janin Henkel et al.   MOLECULAR MEDICINE

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

(2017) Yasutaka Miyachi et al.   Cell Reports

Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis

(2017) Yasushi Honda et al.   Scientific Reports

GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells

(2017) Quan Li et al.   Scientific Reports

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis

(2016) Nathalie Hennuyer et al.   ATHEROSCLEROSIS

Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition

(2016) Weihua Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Molecular Pathogenesis of NASH

(2016) Alessandra Caligiuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mechanisms of intrahepatic triglyceride accumulation

(2016) Claudia Ress   WORLD JOURNAL OF GASTROENTEROLOGY

Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease

(2016) Hirotaka Shoji et al.   Scientific Reports

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver

(2015) Sana Raza-Iqbal et al.   Journal of Atherosclerosis and Thrombosis

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

(2015) Dan Zhou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

(2015) Masashi Miyao et al.   LABORATORY INVESTIGATION

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

(2015) Chiara Saponaro et al.   Nutrients

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

PPARβ/δ activation of CD300a controls intestinal immunity

(2014) Toshiya Tanaka et al.   Scientific Reports

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum

(2011) Pamela J. McFie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes

(2008) Hideaki Miyoshi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans

(2008) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL