Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

(2016) Paula Walle et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatic and serum lipid signatures specific to nonalcoholic steatohepatitis in murine models

(2016) Franck Chiappini et al.   Scientific Reports

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids

(2015) Bianca M. Arendt et al.   HEPATOLOGY

Non-alcoholic fatty liver – Perhaps not so benign

(2015) Leon A. Adams et al.   JOURNAL OF HEPATOLOGY

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

(2015) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Oleic acid modulates mRNA expression of liver X receptor (LXR) and its target genes ABCA1 and SREBP1c in human neutrophils

(2014) María Edith Reyes-Quiroz et al.   EUROPEAN JOURNAL OF NUTRITION

Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway

(2014) Ju-Hee Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease

(2014) Maryann Maximos et al.   HEPATOLOGY

Fattyaciddesaturase 1gene polymorphisms control human hepatic lipid composition

(2014) Libo Wang et al.   HEPATOLOGY

Ventromedial hypothalamus–specific Ptpn1 deletion exacerbates diet-induced obesity in female mice

(2014) Franck Chiappini et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma

(2013) K. Muir et al.   CANCER RESEARCH

Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis

(2013) Cristina López-Vicario et al.   GUT

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Membrane lipid unsaturation as physiological adaptation to animal longevity

(2013) Alba Naudí et al.   Frontiers in Physiology

In Situ Chemical Composition Analysis of Cirrhosis by Combining Synchrotron Fourier Transform Infrared and Synchrotron X-ray Fluorescence Microspectroscopies on the Same Tissue Section

(2012) François Le Naour et al.   ANALYTICAL CHEMISTRY

Characterization of lipid and lipoprotein metabolism in primary human hepatocytes

(2012) Ji Ling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

(2012) Naoki Tanaka et al.   HEPATOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Micrometric molecular histology of lipids by mass spectrometry imaging

(2011) David Touboul et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation

(2011) Sandra Pelz et al.   EXPERIMENTAL CELL RESEARCH

High-resolution, imaging TOF-SIMS: novel applications in medical research

(2010) Per Malmberg et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Multimodal Spectroscopy Combining Time-of-Flight-Secondary Ion Mass Spectrometry, Synchrotron-FT-IR, and Synchrotron-UV Microspectroscopies on the Same Tissue Section

(2010) Vanessa W. Petit et al.   ANALYTICAL CHEMISTRY

Mass spectrometry imaging: Towards a lipid microscope?

(2010) David Touboul et al.   BIOCHIMIE

Fatty acid regulation of hepatic lipid metabolism

(2010) Donald B Jump   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes

(2010) Philippe Podevin et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

In SituLipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging

(2009) Delphine Debois et al.   ANALYTICAL CHEMISTRY

Assessment of Hepatic Steatosis by Expert Pathologists

(2009) Ashraf Mohammad El-Badry et al.   ANNALS OF SURGERY

Relationship Between Polymerase Gamma (POLG) Polymorphisms and Antiretroviral Therapy-Induced Lipodystrophy in HIV-1 Infected Patients: A Case-Control Study

(2009) Franck Chiappini et al.   CURRENT HIV RESEARCH

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Decreased Liver Fatty Acid Δ-6 and Δ-5 Desaturase Activity in Obese Patients

(2009) Julia Araya et al.   Obesity

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum

(2009) Anna Kotronen et al.   Obesity

Chemical Imaging on Liver Steatosis Using Synchrotron Infrared and ToF-SIMS Microspectroscopies

(2009) François Le Naour et al.   PLoS One

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis

(2008) Thomas Pusl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of hepatic fatty acid elongase 5 by LXRα–SREBP-1c

(2008) Yan Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH

Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition

(2008) Yun Wang et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY