Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6

(2020) Li-Xing Tian et al.   CELLULAR IMMUNOLOGY

Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer’s Disease Mice

(2020) Baruh Polis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation

(2020) Yaguang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

(2020) Yi Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vasorelaxant effects of Crataegus pentagyna: Links with arginase inhibition and phenolic profile

(2020) Alexandra Bujor et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo

(2020) Mariska P.M. Van den Berg et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy

(2020) Matthew J. Mitcheltree et al.   ACS Medicinal Chemistry Letters

Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors

(2020) Roman Blaszczyk et al.   ACS Medicinal Chemistry Letters

Arginase inhibitory properties of flavonoid compounds from the leaves of Mulberry ( Morus alba , Moraceae)

(2020) Kamel Arraki et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Altered brain arginine metabolism in a mouse model of tauopathy

(2019) Pranav Vemula et al.   AMINO ACIDS

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

(2019) Juan J. Miret et al.   Journal for ImmunoTherapy of Cancer

Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase

(2019) Irena Roci et al.   Cell Reports

Engineered immune cells as highly sensitive cancer diagnostics

(2019) Amin Aalipour et al.   NATURE BIOTECHNOLOGY

Anti-PD-L1 treatment results in functional remodeling of the macrophage compartment

(2019) Huizhong Xiong et al.   CANCER RESEARCH

A method for visualizing fluorescence of flavonoid therapeutics in vivo in the model eukaryote Dictyostelium discoideum

(2019) Billy T Ferrara et al.   BIOTECHNIQUES

Combination of L-Arginine and L-Norvaline protects against pulmonary fibrosis progression induced by bleomycin in mice

(2019) Lu Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis

(2019) Nicole Hannemann et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

(2019) Yiming Zhang et al.   Nature Communications

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

(2019) Malgorzata Czystowska-Kuzmicz et al.   Nature Communications

Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

(2019) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel

(2019) Yu-Sheng Wu et al.   MOLECULAR PHARMACOLOGY

440OPhase I study of the arginase inhibitor INCB001158 (1158) alone and in combination with pembrolizumab (PEM) in patients (Pts) with advanced/metastatic (adv/met) solid tumours

(2019) A Naing et al.   ANNALS OF ONCOLOGY

160P Novel arginase inhibitor alone and in combination with an immune check point inhibitor reduces tumour growth in murine experimental gliomas

(2019) P Pilanc-kudlek et al.   ANNALS OF ONCOLOGY

Applications of fluorine-containing amino acids for drug design

(2019) Haibo Mei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Arginase Isoform Expression in Chronic Rhinosinusitis

(2019) Diana Vlad et al.   Journal of Clinical Medicine

In situ and real-time imaging of superoxide anion and peroxynitrite elucidating arginase 1 nitration aggravating hepatic ischemia-reperfusion injury

(2019) Wen Zhang et al.   BIOMATERIALS

Synthesis and biological evaluation of [18F](2S,4S)4-(3-fluoropropyl) arginine as a tumor imaging agent

(2019) Renbo Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats

(2019) Nikolay Avtandilyan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Gold Nanoparticle-Based Photoluminescent Nanoswitch Controlled by Host–Guest Recognition and Enzymatic Hydrolysis for Arginase Activity Assay

(2018) Hao-Hua Deng et al.   ACS Applied Materials & Interfaces

Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats

(2018) Kelly J. Peyton et al.   AMINO ACIDS

Bryophyllum pinnatum inhibits arginase II activity and prevents oxidative damage occasioned by carbon tetrachloride (CCl 4 ) in rats

(2018) Scholastica Onyebuchi Anadozie et al.   BIOMEDICINE & PHARMACOTHERAPY

Rational design of novel irreversible inhibitors for human arginase

(2018) Xuefeng Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel photoluminescence enzyme immunoassay based on supramolecular host-guest recognition using L -arginine/6-aza-2-thiothymine-stabilized gold nanocluster

(2018) Youmei Wang et al.   BIOSENSORS & BIOELECTRONICS

Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine

(2018) Teresa Berninger et al.   BIOSENSORS & BIOELECTRONICS

Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

(2018) Mariam Choudry et al.   IMMUNOLOGY

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

(2018) Carmela De Santo et al.   Journal of Hematology & Oncology

Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia

(2018) A.H. Cull et al.   LEUKEMIA RESEARCH

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes

(2018) Huina Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions

(2018) Xiaoyun Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice

(2018) Amanda A. Felizardo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cerebroprotective effects of hydrogen sulfide in homocysteine-induced neurovascular permeability: Involvement of oxidative stress, arginase, and matrix metalloproteinase-9

(2018) Nibendu Nath et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke

(2018) Hanna Yoo et al.   MOLECULAR NEUROBIOLOGY

The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

(2018) King Pan Ng et al.   PLoS One

Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome

(2018) Xiao-Kun Li et al.   Science Translational Medicine

Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance

(2018) S. Tommasi et al.   Scientific Reports

The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma

(2018) Jia You et al.   Biomed Research International

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

(2018) Qinrui Fu et al.   ADVANCED MATERIALS

Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

(2018) Livingstone Fultang et al.   CANCER RESEARCH

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

(2018) Francis Mussai et al.   INTERNATIONAL JOURNAL OF CANCER

Phytochemical screening and arginase inhibitory activity of extracts from several Tunisian medicinal plants

(2018) R. Attia et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

(2018) Surabhi Chandra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET)

(2017) Joshua Clark et al.   JOURNAL OF FLUORINE CHEMISTRY

M1 Means Kill; M2 Means Heal

(2017) Klaus Ley   JOURNAL OF IMMUNOLOGY

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase

(2017) Nuria Villalba et al.   JOURNAL OF NEUROTRAUMA

Critical role for arginase 2 in obesity-associated pancreatic cancer

(2017) Tamara Zaytouni et al.   Nature Communications

Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

(2017) Elisabeth Müller et al.   Frontiers in Immunology

Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT

(2017) Brian P. Rempel et al.   Molecular Imaging

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

1115PTHE CHARACTERISATION OF ARGINASE-1 EXPRESSING MYELOID-DERIVED SUPPRESSOR CELLS IN ADVANCED MELANOMA

(2017) C. Bailey et al.   ANNALS OF ONCOLOGY

Arginine metabolic endotypes related to asthma severity

(2017) Weiling Xu et al.   PLoS One

Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

(2017) Jérémie Mortier et al.   Scientific Reports

Targeting myeloid cells in the tumor sustaining microenvironment

(2017) Jonathan Schupp et al.   CELLULAR IMMUNOLOGY

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice

(2016) Jochen Steppan et al.   ANESTHESIA AND ANALGESIA

Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II

(2016) Bhuvana A. Setty et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Asymmetric dimethylarginine and related metabolites in exhaled breath condensate of children with cystic fibrosis

(2016) Francesca Lucca et al.   Clinical Respiratory Journal

Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors

(2016) Khaled S. Abdelkawy et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

(2016) Weiling Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Arginine Metabolism Revisited

(2016) Sidney M Morris   JOURNAL OF NUTRITION

Semi-automated radiosynthesis of 18F-labeled l-arginine derivative as a potential PET tracer for lung cancer imaging

(2016) Siyuan Gao et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation

(2016) Manuel Lasch et al.   LABORATORY INVESTIGATION

Arginase Inhibitors: A Rational Approach Over One Century

(2016) Marc Pudlo et al.   MEDICINAL RESEARCH REVIEWS

Arginase Inhibitor 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function

(2016) Bonggu Yi et al.   PLANTA MEDICA

Investigation of Mammal Arginase Inhibitory Properties of Natural Ubiquitous Polyphenols by Using an Optimized Colorimetric Microplate Assay

(2016) Simon Bordage et al.   PLANTA MEDICA

Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation

(2016) Minh Cong Nguyen et al.   YONSEI MEDICAL JOURNAL

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype

(2016) Fan Zhang et al.   Oncotarget

Molecular imaging of enzyme activity in vivo using activatable probes

(2016) Runqi Yan et al.   Science Bulletin

Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages

(2016) Ian Zhang et al.   PLoS One

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs

(2015) Hartmut Grasemann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease

(2015) Stefano Patassini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Re(I) and Tc(I) Complexes for Targeting Nitric Oxide Synthase: Influence of the Chelator in the Affinity for the Enzyme

(2015) Bruno L. Oliveira et al.   Chemical Biology & Drug Design

FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1Novelty and Significance

(2015) Min Zhu et al.   CIRCULATION RESEARCH

Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma

(2015) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

L-Arginine administration attenuates airway inflammation by altering L-arginine metabolism in an NC/Nga mouse model of asthma

(2015) Ran Zhang et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis

(2015) Leticia Monin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mature Cystic Fibrosis Airway Neutrophils Suppress T Cell Function: Evidence for a Role of Arginase 1 but Not Programmed Death-Ligand 1

(2015) Sarah A. Ingersoll et al.   JOURNAL OF IMMUNOLOGY

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

(2015) Lin Wang et al.   MICROVASCULAR RESEARCH

The Promise of Plant-Derived Substances as Inhibitors of Arginase

(2015) C. Girard-Thernier et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia

(2015) YanBiao Chu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients

(2015) NAICHUN ZHANG et al.   Molecular Medicine Reports

Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction

(2015) Riccardo Lacchini et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Deletion of Genes Encoding Arginase Improves Use of “Heavy” Isotope-Labeled Arginine for Mass Spectrometry in Fission Yeast

(2015) Weronika E. Borek et al.   PLoS One

Arginase: an old enzyme with new tricks

(2015) Ruth B. Caldwell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats

(2015) Jin Sun Cho et al.   BMC Anesthesiology

Detecting Enzyme Activities with Exogenous MRI Contrast Agents

(2014) Dina V. Hingorani et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Particulate Biochromatographic Support for the Research of Arginase Inhibitors Doped with Nanomaterials: Differences Observed Between Carbon and Boron Nitride Nanotubes. Application to Three Plant Extracts

(2014) Claire André et al.   CHROMATOGRAPHIA

Immunosuppression in cervical cancer with special reference to arginase activity

(2014) Astrid M. Bedoya et al.   GYNECOLOGIC ONCOLOGY

Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues

(2014) Christine M. Hochstedler et al.   JOURNAL OF HISTOTECHNOLOGY

Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration

(2014) K. Ckless et al.   JOURNAL OF IMMUNOLOGY

Imaging Pulmonary Inducible Nitric Oxide Synthase Expression with PET

(2014) H. J. Huang et al.   JOURNAL OF NUCLEAR MEDICINE

Altered arginine metabolism in Alzheimer's disease brains

(2014) Ping Liu et al.   NEUROBIOLOGY OF AGING

Effect of Arginase Inhibition on Pulmonary L-Arginine Metabolism in Murine Pseudomonas Pneumonia

(2014) Anne Mehl et al.   PLoS One

Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma

(2013) Z. Arıkan-Ayyıldız et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica

(2013) Sang Won Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice

(2013) Vania C. Olivon et al.   ATHEROSCLEROSIS

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arginase inhibition by piceatannol-3′-O-β-D-glucopyranoside improves endothelial dysfunction via activation of endothelial nitric oxide synthase in ApoE-null mice fed a high-cholesterol diet

(2013) AINIENG WOO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Impact of Substrate Protonation and Tautomerization States on Interactions with the Active Site of Arginase I

(2013) Shanthi Nagagarajan et al.   Journal of Chemical Information and Modeling

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

(2013) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radiolabeled Amino Acids for Oncologic Imaging

(2013) C. Huang et al.   JOURNAL OF NUCLEAR MEDICINE

Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

(2013) Zuzana Havlinova et al.   XENOBIOTICA

Korean red ginseng inhibits arginase and contributes to endothelium-dependent vasorelaxation through endothelial nitric oxide synthase coupling

(2013) Woosung Shin et al.   Journal of Ginseng Research

Role of Arginase in Vessel Wall Remodeling

(2013) William Durante   Frontiers in Immunology

Feasibility and Dosimetry Studies for 18F-NOS as a Potential PET Radiopharmaceutical for Inducible Nitric Oxide Synthase in Humans

(2012) P. Herrero et al.   JOURNAL OF NUCLEAR MEDICINE

Synthesis and Properties of a Sterically Unencumbered δ-Silanediol Amino Acid

(2012) Jin Kyung Kim et al.   JOURNAL OF ORGANIC CHEMISTRY

Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases

(2012) Nathan D. Roe et al.   VASCULAR PHARMACOLOGY

Susceptibility to hydrolysis of phenylboronic pinacol esters at physiological pH

(2012) Cesare Achilli et al.   Open Chemistry

Immunohistochemical study of arginase 1 and 2 in various tissues of rats

(2011) Sungyoung Choi et al.   ACTA HISTOCHEMICA

Strategies for in vivo imaging of enzyme activity: an overview and recent advances

(2011) Andrew Razgulin et al.   CHEMICAL SOCIETY REVIEWS

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

(2011) Monica Ilies et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new arginase enzymatic reactor: Development and application for the research of plant-derived inhibitors

(2011) Claire André et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Arginase Inhibition by Ethylacetate Extract ofCaesalpinia sappanLignum Contributes to Activation of Endothelial Nitric Oxide Synthase

(2011) Woosung Shin et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

(2011) Gisela Lättig-Tünnemann et al.   Nature Communications

Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model

(2010) Noriko Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of human arginase I by substrate and product analogues

(2010) Luigi Di Costanzo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Piceatannol-3'-O-β-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity

(2010) Ainieng Woo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Impact of Arginase II on CBF in Experimental Cortical Impact Injury in Mice Using MRI

(2010) Brittany R Bitner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of L-Arginine Metabolizing Enzymes by L-Arginine-Derived Advanced Glycation End Products

(2010) Ying-Ling Lai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I

(2010) Monica Ilies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endothelial arginase II responds to pharmacological inhibition by elevation in protein level

(2010) Karina Krotova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets

(2010) Aaron Erdely et al.   PLoS One

TPL-2-Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability

(2010) V. Mieulet et al.   Science Signaling

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope

(2009) Rie Mukai et al.   CYTOTECHNOLOGY

Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

(2009) Teddy Bagnost et al.   JOURNAL OF HYPERTENSION

Diffusion Tensor Imaging in Arginase Deficiency Reveals Damage to Corticospinal Tracts

(2009) Michael S. Oldham et al.   PEDIATRIC NEUROLOGY

Systemic abnormalities in liver disease

(2009) Masami Minemura et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

(2008) Harm Maarsingh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo

(2008) Oliver Schnorr et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis and Application of [18F]FDG-Maleimidehexyloxime ([18F]FDG-MHO): A [18F]FDG-Based Prosthetic Group for the Chemoselective18F-Labeling of Peptides and Proteins†

(2008) Frank Wuest et al.   BIOCONJUGATE CHEMISTRY

Evolution of the arginase fold and functional diversity

(2008) D. P. Dowling et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Arginase II

(2008) Sungwoo Ryoo et al.   CIRCULATION RESEARCH

iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells

(2008) Feng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

(S)-2-Amino-6-nitrohexanoic Acid Binds to Human Arginase I through Multiple Nitro−Metal Coordination Interactions in the Binuclear Manganese Cluster

(2008) Tatiana Y. Zakharian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arginase blockade lessens endothelial dysfunction after thrombosis

(2008) Chandani Lewis et al.   JOURNAL OF VASCULAR SURGERY

The discovery of nitric oxide and its role in vascular biology

(2006) S Moncada et al.   BRITISH JOURNAL OF PHARMACOLOGY