Arginase Inhibitors: A Rational Approach Over One Century

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

(2016) Dana M. Hardbower et al.   AMINO ACIDS

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis

(2016) Claudia C. Maquiaveli et al.   JOURNAL OF NATURAL PRODUCTS

Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans

(2016) Mariam El Assar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets

(2016) Sanja Glisic et al.   MOLECULES

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Novel Selective Inhibitor ofLeishmania (Leishmania) amazonensisArginase

(2015) Edson R. da Silva et al.   Chemical Biology & Drug Design

Arginase I Release from Activated Neutrophils Induces Peripheral Immunosuppression in a Murine Model of Stroke

(2015) Trisha R Sippel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mature Cystic Fibrosis Airway Neutrophils Suppress T Cell Function: Evidence for a Role of Arginase 1 but Not Programmed Death-Ligand 1

(2015) Sarah A. Ingersoll et al.   JOURNAL OF IMMUNOLOGY

Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels

(2015) O. Kovamees et al.   JOURNAL OF INTERNAL MEDICINE

Antiretrovirals inhibit arginase in human microglia

(2015) Lucia Lisi et al.   JOURNAL OF NEUROCHEMISTRY

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

(2015) J. B. Hunt et al.   JOURNAL OF NEUROSCIENCE

The Promise of Plant-Derived Substances as Inhibitors of Arginase

(2015) C. Girard-Thernier et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia

(2015) YanBiao Chu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Boronic Acids and Derivatives—Probing the Structure–Activity Relationships for Mutagenicity

(2015) Marvin M. Hansen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Arginase: an old enzyme with new tricks

(2015) Ruth B. Caldwell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity

(2015) Ashley B. Petrone et al.   Translational Stroke Research

Arginase inhibition restores endothelial function in diet-induced obesity

(2014) Ji Hyung Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis

(2014) Yang Hai et al.   BIOCHEMISTRY

OxLDL Triggers Retrograde Translocation of Arginase2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase

(2014) Deepesh Pandey et al.   CIRCULATION RESEARCH

Increased arginase levels contribute to impaired perfusion after cardiopulmonary resuscitation

(2014) Christian Jung et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Isolation of Arginase Inhibitors from the Bioactivity-Guided Fractionation of Byrsonima coccolobifolia Leaves and Stems

(2014) Lorena Ramos Freitas de Sousa et al.   JOURNAL OF NATURAL PRODUCTS

Effect of Arginase Inhibition on Ischemia-Reperfusion Injury in Patients with Coronary Artery Disease with and without Diabetes Mellitus

(2014) Oskar Kövamees et al.   PLoS One

Arginase 2 Deficiency Prevents Oxidative Stress and Limits Hyperoxia-Induced Retinal Vascular Degeneration

(2014) Jutamas Suwanpradid et al.   PLoS One

Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice

(2014) Marka R. Crittenden et al.   RADIATION RESEARCH

Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice

(2014) Jeongyeon Yoon et al.   VASCULAR PHARMACOLOGY

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections

(2013) Edward L. D’Antonio et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica

(2013) Sang Won Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Contribution of arginase activation to vascular dysfunction in cigarette smoking

(2013) Gautam Sikka et al.   ATHEROSCLEROSIS

Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice

(2013) Vania C. Olivon et al.   ATHEROSCLEROSIS

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

An assessment of the genetic toxicology of novel boron-containing therapeutic agents

(2013) Vic Ciaravino et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation

(2013) Xu-Ping Wang et al.   EUROPEAN HEART JOURNAL

Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection

(2013) Leticia Correa Manjolin et al.   FOOD CHEMISTRY

Impact of Substrate Protonation and Tautomerization States on Interactions with the Active Site of Arginase I

(2013) Shanthi Nagagarajan et al.   Journal of Chemical Information and Modeling

Local Arginase 1 Activity Is Required for Cutaneous Wound Healing

(2013) Laura Campbell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

(2013) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement

(2013) Ebenézer de Mello Cruz et al.   PHYTOCHEMISTRY

Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions

(2013) Matheus Balduíno Goncalves dos Reis et al.   PLoS One

Arginase in retinopathy

(2013) S. Priya Narayanan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

(2013) Zuzana Havlinova et al.   XENOBIOTICA

Role of Arginase in Vessel Wall Remodeling

(2013) William Durante   Frontiers in Immunology

Arginase 1 Mediates Increased Blood Pressure and Contributes to Vascular Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertension

(2013) Haroldo A. Toque et al.   Frontiers in Immunology

Arginase as a mediator of diabetic retinopathy

(2013) Chintan Patel   Frontiers in Immunology

Binding of the unreactive substrate analogL-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I

(2012) Edward L. D'Antonio et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Structure and Function of Non-Native Metal Clusters in Human Arginase I

(2012) Edward L. D’Antonio et al.   BIOCHEMISTRY

Arginase enzymes in the human prostate: expression of arginase isoenzymes and effects of arginase inhibitors on isolated human prostate tissue

(2012) George T. Kedia et al.   BJU INTERNATIONAL

Arginase II Inhibitory Activity of Phenolic Compounds from Saururus chinensis

(2012) Chae-Jin Lim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

(2012) Edson Roberto da Silva et al.   EXPERIMENTAL PARASITOLOGY

Homology modeling, docking and molecular dynamics of the Leishmania mexicana arginase: A description of the catalytic site useful for drug design

(2012) Carlos A. Méndez-Cuesta et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Immunohistochemical study of arginase 1 and 2 in various tissues of rats

(2011) Sungyoung Choi et al.   ACTA HISTOCHEMICA

Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes

(2011) Timea Beleznai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetes-induced vascular dysfunction involves arginase I

(2011) Maritza J. Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Crystal Structures of Complexes with Cobalt-Reconstituted Human Arginase I

(2011) Edward L. D’Antonio et al.   BIOCHEMISTRY

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8

(2011) Monica Ilies et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

(2011) Monica Ilies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

(2011) Rafael Balaña-Fouce et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Modeling gas phase nitric oxide release in lung epithelial cells

(2011) Jingjing Jiang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

New tricks new ways: Exploitation of a multifunctional enzyme arginase by pathogens

(2011) Amit Lahiri et al.   Virulence

Inhibition of human arginase I by substrate and product analogues

(2010) Luigi Di Costanzo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

(2010) Sungwoo Ryoo et al.   ATHEROSCLEROSIS

Crystal Structure of Arginase fromPlasmodium falciparumand Implications forl-Arginine Depletion in Malarial Infection,

(2010) Daniel P. Dowling et al.   BIOCHEMISTRY

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

(2010) Teddy Bagnost et al.   CARDIOVASCULAR RESEARCH

Piceatannol-3'-O-β-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity

(2010) Ainieng Woo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I

(2010) Monica Ilies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice

(2010) Haroldo A. Toque et al.   Journal of Sexual Medicine

Modulation of the Arginase Pathway in the Context of Microbial Pathogenesis: A Metabolic Enzyme Moonlighting as an Immune Modulator

(2010) Priyanka Das et al.   PLoS Pathogens

Infrastructure for the life sciences: design and implementation of the UniProt website

(2009) Eric Jain et al.   BMC BIOINFORMATICS

Vascular dysfunction in retinopathy—An emerging role for arginase

(2009) Ruth B. Caldwell et al.   BRAIN RESEARCH BULLETIN

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

(2009) Harm Maarsingh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

(2009) Teddy Bagnost et al.   JOURNAL OF HYPERTENSION

Molecular modeling of Helicobacter pylori arginase and the inhibitor coordination interactions

(2009) Homa Azizian et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

(2009) Rosa M. Reguera et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue

(2009) Johan M. Lorenzen et al.   WORLD JOURNAL OF UROLOGY

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Arginine metabolism and nutrition in growth, health and disease

(2008) Guoyao Wu et al.   AMINO ACIDS

Probing the Specificity Determinants of Amino Acid Recognition by Arginase†‡

(2008) Ekaterina Y. Shishova et al.   BIOCHEMISTRY

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Possible Involvement of Altered Arginase Activity, Arginase Type I and Type II Expressions, and Nitric Oxide Production in Occurrence of Intimal Hyperplasia in Premenopausal Human Uterine Arteries

(2008) Galina Vasileva Marinova et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

(S)-2-Amino-6-nitrohexanoic Acid Binds to Human Arginase I through Multiple Nitro−Metal Coordination Interactions in the Binuclear Manganese Cluster

(2008) Tatiana Y. Zakharian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contrasting features of urea cycle disorders in human patients and knockout mouse models

(2008) Joshua L. Deignan et al.   MOLECULAR GENETICS AND METABOLISM

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

(2008) Tatiana Y. Zakharian et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH