Strategies for in vivo imaging of enzyme activity: an overview and recent advances

A Flexible and Stereoselective Synthesis of Azetidin-3-ones through Gold-Catalyzed Intermolecular Oxidation of Alkynes

(2011) Longwu Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia

(2010) Qunzhao Wang et al.   ACS Chemical Biology

Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

(2010) David H. Kwan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Secreted Enzyme Reporter System for MRI

(2010) Gil G. Westmeyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Evaluation of64Cu-Labeled Magnetic Nanoparticles as a Dual-Modality PET/MR Imaging Agent

(2010) Charles Glaus et al.   BIOCONJUGATE CHEMISTRY

Heparin immobilized gold nanoparticles for targeted detection and apoptotic death of metastatic cancer cells

(2010) Kyuri Lee et al.   BIOMATERIALS

Alternatives to Gadolinium-Based Metal Chelates for Magnetic Resonance Imaging†

(2010) Subha Viswanathan et al.   CHEMICAL REVIEWS

In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New Depths

(2010) Chulhong Kim et al.   CHEMICAL REVIEWS

Challenges for Molecular Magnetic Resonance Imaging

(2010) Enzo Terreno et al.   CHEMICAL REVIEWS

Designing multifunctional quantum dots for bioimaging, detection, and drug delivery

(2010) Pavel Zrazhevskiy et al.   CHEMICAL SOCIETY REVIEWS

Delivering quantum dots to cells: bioconjugated quantum dots for targeted and nonspecific extracellular and intracellular imaging

(2010) Vasudevanpillai Biju et al.   CHEMICAL SOCIETY REVIEWS

Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology

(2010) Natasha Thorne et al.   CHEMISTRY & BIOLOGY

Molecular imaging: current status and emerging strategies

(2010) M.A. Pysz et al.   CLINICAL RADIOLOGY

Inhibition of NF- B Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia coli Effector Protein NleE

(2010) A. Vossenkamper et al.   JOURNAL OF IMMUNOLOGY

Near-Infrared Light Emitting Luciferase via Biomineralization

(2010) Nan Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Robust Light Emission from Cyclic Alkylaminoluciferin Substrates for Firefly Luciferase

(2010) Gadarla Randheer Reddy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Imaging of an Activatable Photoacoustic Probe

(2010) Jelena Levi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

S-Gal®, A novel 1H MRI reporter for β-galactosidase

(2010) Weina Cui et al.   MAGNETIC RESONANCE IN MEDICINE

A robust coregistration method forin vivostudies using a first generation simultaneous PET/MR scanner

(2010) Thomas S. C. Ng et al.   MEDICAL PHYSICS

High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation

(2010) Mikako Ogawa et al.   Molecular BioSystems

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

(2010) Stephan Kontos et al.   MOLECULAR PHARMACEUTICS

Imaging β-Galactosidase Activity in Human Tumor Xenografts and Transgenic Mice Using a Chemiluminescent Substrate

(2010) Li Liu et al.   PLoS One

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

(2010) Q. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging tuberculosis with endogenous  -lactamase reporter enzyme fluorescence in live mice

(2010) Y. Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H-Type Dimer Formation of Fluorophores: A Mechanism for Activatable,in VivoOptical Molecular Imaging

(2009) Mikako Ogawa et al.   ACS Chemical Biology

Development of Near-Infrared Fluorophore (NIRF)-Labeled Activity-Based Probes forin VivoImaging of Legumain

(2009) Jiyoun Lee et al.   ACS Chemical Biology

Red-emitting luciferases for bioluminescence reporter and imaging applications

(2009) Bruce R. Branchini et al.   ANALYTICAL BIOCHEMISTRY

Engineering Bioluminescent Proteins: Expanding their Analytical Potential

(2009) Laura Rowe et al.   ANALYTICAL CHEMISTRY

Ring-Opening Polymerization with Synergistic Co-monomers: Access to a Boronate-Functionalized Polymeric Monolith for the Specific Capture ofcis-Diol-Containing Biomolecules under Neutral Conditions

(2009) Lianbing Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-Function Probe to Detect Protease Activity for Fluorescence Measurement and19F MRI

(2009) Shin Mizukami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Optical Imaging of LacZ Expression Using lacZ Transgenic Mice

(2009) Guo-Jun Zhang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates

(2009) Anca Dragulescu-Andrasi et al.   BIOCONJUGATE CHEMISTRY

An Improved Cell-Penetrating, Caspase-Activatable, Near-Infrared Fluorescent Peptide for Apoptosis Imaging

(2009) Dustin Maxwell et al.   BIOCONJUGATE CHEMISTRY

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

(2009) Eiji Nakata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin duringToxoplasma gondiiinfection

(2009) Melissa B. Lodoen et al.   CELLULAR MICROBIOLOGY

Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

(2009) Young-Pil Kim et al.   CHEMICAL COMMUNICATIONS

Genetically encoded biosensors based on engineered fluorescent proteins

(2009) Wolf B. Frommer et al.   CHEMICAL SOCIETY REVIEWS

Cell-Permeable [99mTc(CO3)]-Labeled Fluorogenic Caspase 3 Substrate for Dual-Modality Detection of Apoptosis

(2009) Chiyi Xiong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery and development of biopharmaceuticals: current issues

(2009) William R Strohl et al.   CURRENT OPINION IN BIOTECHNOLOGY

Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model

(2009) Rahul Anil Sheth et al.   GYNECOLOGIC ONCOLOGY

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

(2009) Emilia S. Olson et al.   Integrative Biology

Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe

(2009) Hyeran Lee et al.   JOURNAL OF BIOMEDICAL OPTICS

In Vivo Near-Infrared Fluorescence Imaging of Matrix Metalloproteinase Activity after Cerebral Ischemia

(2009) Jan Klohs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging

(2009) Beata Jastrzȩbska et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications

(2009) Frederic Leblond et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Protein Nanoparticles Engineered to Sense Kinase Activity in MRI

(2009) Mikhail G. Shapiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalent Protein Labeling Based on Noncatalytic β-Lactamase and a Designed FRET Substrate

(2009) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activatable Magnetic Resonance Imaging Agents for Myeloperoxidase Sensing: Mechanism of Activation, Stability, and Toxicity

(2009) Elisenda Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy

(2009) S. H. Thorne et al.   MOLECULAR CANCER THERAPEUTICS

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging

(2009) Yousuke Takaoka et al.   Nature Chemistry

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

Conformational behaviour determines the low-relaxivity state of a conditional MRI contrast agent

(2009) Ugo Cosentino et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity

(2009) Galia Blum et al.   PLoS One

Anthrax Toxin Uptake by Primary Immune Cells as Determined with a Lethal Factor-β-Lactamase Fusion Protein

(2009) Haijing Hu et al.   PLoS One

In vivo far-red luminescence imaging of a biomarker based on BRET from Cypridina bioluminescence to an organic dye

(2009) C. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model

(2009) E. M. Barnett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carotid Artery Brain Aneurysm Model: In Vivo Molecular Enzyme-specific MR Imaging of Active Inflammation in a Pilot Study

(2009) Michael J. DeLeo et al.   RADIOLOGY

Cadmium-containing nanoparticles: Perspectives on pharmacology and toxicology of quantum dots☆

(2009) Beverly A. Rzigalinski et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A catalytically and genetically optimized β-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

(2009) Mike C Wolf et al.   Virology Journal

Enzymatic Hydrogelation of Small Molecules

(2008) Zhimou Yang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multiplex Detection of Protease Activity with Quantum Dot Nanosensors Prepared by Intein-Mediated Specific Bioconjugation

(2008) Zuyong Xia et al.   ANALYTICAL CHEMISTRY

A Hybrid Nanoparticle Probe for Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging

(2008) Jin-sil Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Near-Infrared-Fluorescence-Quenched Gold-Nanoparticle Imaging Probe for In Vivo Drug Screening and Protease Activity Determination

(2008) Seulki Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Enzymatic Activity by PARACEST MRI: A General Approach to Target a Large Variety of Enzymes

(2008) Thomas Chauvin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protease-Specific Nanosensors for Magnetic Resonance Imaging

(2008) Eyk Schellenberger et al.   BIOCONJUGATE CHEMISTRY

Determination of Optimal Rhodamine Fluorophore forin VivoOptical Imaging

(2008) Michelle R. Longmire et al.   BIOCONJUGATE CHEMISTRY

Structural Modification of Protease Inducible Preprogrammed Nanofiber Precursor

(2008) Benedict Law et al.   BIOMACROMOLECULES

Development of an optimized activatable MMP-14 targeted SPECT imaging probe

(2008) Gregory A. Watkins et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Self-Cleavable Bioluminogenic Luciferin Phosphates as Alkaline Phosphatase Reporters

(2008) Wenhui Zhou et al.   CHEMBIOCHEM

GFP Family: Structural Insights into Spectral Tuning

(2008) Alexey A. Pakhomov et al.   CHEMISTRY & BIOLOGY

Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging

(2008) P. Brader et al.   CLINICAL CANCER RESEARCH

Monitoring Caspase-3 Activation with a Multimodality Imaging Sensor in Living Subjects

(2008) P. Ray et al.   CLINICAL CANCER RESEARCH

Firefly bioluminescence: A mechanistic approach of luciferase catalyzed reactions

(2008) Simone M. Marques et al.   IUBMB LIFE

Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging

(2008) Jodi Haller et al.   JOURNAL OF APPLIED PHYSIOLOGY

PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)-Conjugated Radiolabeled Iron Oxide Nanoparticles

(2008) H.-Y. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging Induction of Cytoprotective Enzymes in Intact Human Cells: Coumberone, a Metabolic Reporter for Human AKR1C Enzymes Reveals Activation by Panaxytriol, an Active Component of Red Ginseng

(2008) Marlin Halim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

T2 relaxation induced by clusters of superparamagnetic nanoparticles: Monte Carlo simulations

(2008) Yuri Matsumoto et al.   MAGNETIC RESONANCE IMAGING

Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model

(2008) Réjean Lebel et al.   MAGNETIC RESONANCE IN MEDICINE

Quantification of bacterial internalization by host cells using a β-lactamase reporter strain: Neisseria gonorrhoeae invasion into cervical epithelial cells requires bacterial viability

(2008) S BISH et al.   MICROBES AND INFECTION

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE

Simultaneous PET-MRI: a new approach for functional and morphological imaging

(2008) Martin S Judenhofer et al.   NATURE MEDICINE

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

(2008) Yasuteru Urano et al.   NATURE MEDICINE

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

A19F-NMR approach using reporter molecule pairs to assessβ-galactosidase in human xenograft tumorsin vivo

(2008) Jian-Xin Yu et al.   NMR IN BIOMEDICINE

A redshifted codon-optimized firefly luciferase is a sensitive reporter for bioluminescence imaging

(2008) Henrike Caysa et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease-Triggered Unveiling of Bioactive Nanoparticles

(2008) Todd J. Harris et al.   Small

Selective Activity-Based Probes for Cysteine Cathepsins

(2007) Anja Watzke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to β-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME) Phenomenon

(2007) Kenjiro Hanaoka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic Investigation of β-Galactosidase-Activated MR Contrast Agents

(2007) Lauren M. Urbanczyk-Pearson et al.   INORGANIC CHEMISTRY

Paramagnetic Relaxation-Based19F MRI Probe To Detect Protease Activity

(2007) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY