Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

(2016) Q. Zhang et al.   BLOOD

DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer

(2016) Krista P. Terracina et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Molecular basis and current strategies of therapeutic arginine depletion for cancer

(2016) Livingstone Fultang et al.   INTERNATIONAL JOURNAL OF CANCER

MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses

(2016) Andre Kunert et al.   JOURNAL OF IMMUNOLOGY

Arginase Inhibitors: A Rational Approach Over One Century

(2016) Marc Pudlo et al.   MEDICINAL RESEARCH REVIEWS

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

(2015) F. Mussai et al.   BLOOD

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

(2015) H. Dombret et al.   BLOOD

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

(2015) F. Mussai et al.   CANCER RESEARCH

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

(2015) S S Kenderian et al.   LEUKEMIA

Treatment of CD33-directed Chimeric Antigen Receptor-modified T Cells in One Patient With Relapsed and Refractory Acute Myeloid Leukemia

(2015) Quan-shun Wang et al.   MOLECULAR THERAPY

Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2

(2014) D. Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer

(2014) K. Odunsi et al.   Cancer Immunology Research

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Wilms’ Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses

(2013) Benjamin Uttenthal et al.   BRITISH JOURNAL OF HAEMATOLOGY

Polyphenol E Enhances the Antitumor Immune Response in Neuroblastoma by Inactivating Myeloid Suppressor Cells

(2013) G. Santilli et al.   CLINICAL CANCER RESEARCH

Phase II Trial of Vorinostat With Idarubicin and Cytarabine for Patients With Newly Diagnosed Acute Myelogenous Leukemia or Myelodysplastic Syndrome

(2012) Guillermo Garcia-Manero et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia

(2011) Djordje Atanackovic et al.   AMERICAN JOURNAL OF HEMATOLOGY

Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

(2010) O. Goodyear et al.   BLOOD

CD8+ T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect

(2010) A. McLarnon et al.   HAEMATOLOGICA