The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

(2017) Naomi McGovern et al.   NATURE

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors

(2016) Khaled S. Abdelkawy et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact

(2016) Kevin Rouault-Pierre et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus

(2016) Oskar Kövamees et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

(2016) Weiling Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation

(2016) Manuel Lasch et al.   LABORATORY INVESTIGATION

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Human cytomegalovirus may promote tumour progression by upregulating arginase-2

(2016) Helena Costa et al.   Oncotarget

Hypoxia and Hypoxia-Inducible Factors in Leukemias

(2016) Margaux Deynoux et al.   Frontiers in Oncology

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

(2015) F. Mussai et al.   CANCER RESEARCH

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

(2015) Charlie R. Mantel et al.   CELL

Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels

(2015) O. Kovamees et al.   JOURNAL OF INTERNAL MEDICINE

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

(2015) Laura J Pallett et al.   NATURE MEDICINE

Hypoxia-inducible factors in cancer stem cells and inflammation

(2015) Gong Peng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

(2014) Yuyan Xiong et al.   Autophagy

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

(2014) Y. Wang et al.   BLOOD

Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition

(2014) K. P. Ng et al.   BLOOD

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Effect of Arginase Inhibition on Ischemia-Reperfusion Injury in Patients with Coronary Artery Disease with and without Diabetes Mellitus

(2014) Oskar Kövamees et al.   PLoS One

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

Activity of the Hypoxia-Activated Prodrug, TH-302, in Preclinical Human Acute Myeloid Leukemia Models

(2013) S. Portwood et al.   CLINICAL CANCER RESEARCH

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

HIF isoforms in the skin differentially regulate systemic arterial pressure

(2013) A. S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production

(2012) Adrian T. Gonon et al.   PLoS One

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxic upregulation of arginase II in human lung endothelial cells

(2010) Karina Krotova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells

(2010) M Fiegl et al.   LEUKEMIA

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression

(2008) Rita Rotondo et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

(2008) David J Tate et al.   Journal of Hematology & Oncology