Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice

(2016) Jochen Steppan et al.   ANESTHESIA AND ANALGESIA

Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors

(2016) Khaled S. Abdelkawy et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Say NO to Obesity-Related Hypertension

(2016) Niwanthi W. Rajapakse et al.   HYPERTENSION

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Safety and Effectiveness of Arginine in Adults

(2016) Catherine J McNeal et al.   JOURNAL OF NUTRITION

Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans

(2016) Mariam El Assar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Arginase Inhibitors: A Rational Approach Over One Century

(2016) Marc Pudlo et al.   MEDICINAL RESEARCH REVIEWS

The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study

(2016) Parvin Mirmiran et al.   Nutrients

Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity

(2015) Huan Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels

(2015) O. Kovamees et al.   JOURNAL OF INTERNAL MEDICINE

Augmented endothelial-specific L-arginine transport prevents obesity-induced hypertension

(2014) N. W. Rajapakse et al.   Acta Physiologica

Arginase promotes endothelial dysfunction and hypertension in obese rats

(2014) Fruzsina K. Johnson et al.   Obesity

Sexual dimorphism in obesity-mediated left ventricular hypertrophy

(2013) Christian Böhm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginase inhibition alleviates hypertension in the metabolic syndrome

(2013) Hany M El-Bassossy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

Obesity and Insulin Resistance Induce Early Development of Diastolic Dysfunction in Young Female Mice Fed a Western Diet

(2013) Camila Manrique et al.   ENDOCRINOLOGY

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight

(2013) M. Atiya Ali et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment-A position paper of theThe Obesity Societyand theAmerican Society of Hypertension

(2013) Lewis Landsberg et al.   Obesity

Increased levels of circulating arginase I in overweight compared to normal weight adolescents

(2013) Christian Jung et al.   PEDIATRIC DIABETES

Increased Plasma Citrulline in Mice Marks Diet-Induced Obesity and May Predict the Development of the Metabolic Syndrome

(2013) Manuela Sailer et al.   PLoS One

Role of Arginase in Vessel Wall Remodeling

(2013) William Durante   Frontiers in Immunology

Protein Tyrosine Phosphatase SHP2 Mediates Chronic Insulin-Induced Endothelial Inflammation

(2012) Hemant Giri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

Effect of a long-term oral l-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trial

(2012) L. D. Monti et al.   DIABETES OBESITY & METABOLISM

Arginase inhibition alleviates hypertension associated with diabetes: Effect on endothelial dependent relaxation and NO production

(2012) Hany M. El-Bassossy et al.   VASCULAR PHARMACOLOGY

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

(2011) Alia Shatanawi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Polyamines Are Increased in Obese Children and Are Related to Markers of Oxidative/Nitrosative Stress and Angiogenesis

(2011) Pilar Codoñer-Franch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat

(2011) Camila Manrique et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome

(2011) Mario Siervo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity

(2011) Oh Yoen Kim et al.   NUTRITION

Insulin resistance in obesity and metabolic syndrome: Is there a connection with platelet l-arginine transport?

(2010) Carmen R.L. Assumpção et al.   BLOOD CELLS MOLECULES AND DISEASES

Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets

(2010) Aaron Erdely et al.   PLoS One

The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries

(2009) NN Huynh et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

(2009) Teddy Bagnost et al.   JOURNAL OF HYPERTENSION

Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases

(2009) Thekkethil P. Nedungadi et al.   Journal of Cardiovascular Translational Research

Endothelial Arginase II

(2008) Sungwoo Ryoo et al.   CIRCULATION RESEARCH

Obesity reduces the bioavailability of nitric oxide in juveniles

(2008) H-J Gruber et al.   INTERNATIONAL JOURNAL OF OBESITY

Dietary l-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats

(2008) Wenjuan Jobgen et al.   JOURNAL OF NUTRITION