Detecting Enzyme Activities with Exogenous MRI Contrast Agents

Flexibility and Reactivity in Promiscuous Enzymes

(2013) Pietro Gatti-Lafranconi et al.   CHEMBIOCHEM

Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate

(2013) A.W. Barb et al.   JOURNAL OF MAGNETIC RESONANCE

Synthesis and Relaxometric Characterization of a MRI Gd-Based Probe Responsive to Glutamic Acid Decarboxylase Enzymatic Activity

(2013) Roberta Napolitano et al.   JOURNAL OF MEDICINAL CHEMISTRY

A CatalyCEST MRI Contrast Agent That Detects the Enzyme-Catalyzed Creation of a Covalent Bond

(2013) Dina V. Hingorani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Hanes-Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI

(2013) Edward A. Randtke et al.   MAGNETIC RESONANCE IN MEDICINE

Detection of in vivo enzyme activity with CatalyCEST MRI

(2013) Byunghee Yoo et al.   MAGNETIC RESONANCE IN MEDICINE

Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

(2013) M. A. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

19F-MRS/1H-MRI dual-function probe for detection of β-galactosidase activity

(2013) Jian-Xin Yu et al.   Chemical Science

19F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface β-Lactamase Activity

(2012) Hisashi Matsushita et al.   CHEMBIOCHEM

A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

(2012) Aneta Keliris et al.   Contrast Media & Molecular Imaging

Assessment of early diabetic renal changes with hyperpolarized [1-13C]pyruvate

(2012) Christoffer Laustsen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

MRI biosensor for protein kinase A encoded by a single synthetic gene

(2012) Raag D. Airan et al.   MAGNETIC RESONANCE IN MEDICINE

Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells

(2012) Alessia Lodi et al.   NMR IN BIOMEDICINE

The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper

(2011) Kenneth A. Johnson et al.   BIOCHEMISTRY

β-Gal Gene Expression MRI Reporter in Melanoma Tumor Cells. Design, Synthesis, andin Vitroandin VivoTesting of a Gd(III) Containing Probe Forming a High Relaxivity, Melanin-Like Structure upon β-Gal Enzymatic Activation

(2011) Francesca Arena et al.   BIOCONJUGATE CHEMISTRY

Bimodal Quantitative Monitoring for Enzymatic Activity with Simultaneous Signal Increases in19F NMR and Fluorescence Using Silica Nanoparticle-Based Molecular Probes

(2011) Kazuo Tanaka et al.   BIOCONJUGATE CHEMISTRY

Strategies for in vivo imaging of enzyme activity: an overview and recent advances

(2011) Andrew Razgulin et al.   CHEMICAL SOCIETY REVIEWS

Gold nanocages as contrast agents for photoacoustic imaging

(2011) Weiyang Li et al.   Contrast Media & Molecular Imaging

Activatable Optical Probes for the Detection of Enzymes

(2011) Christopher R. Drake et al.   CURRENT ORGANIC SYNTHESIS

Lanthanide Complexes as Paramagnetic Probes for 19F Magnetic Resonance

(2011) Peter Harvey et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Monitoring Enzyme Activity Using a Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agent

(2011) Guanshu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time Molecular Imaging of Tricarboxylic Acid Cycle Metabolism in Vivo by Hyperpolarized 1-13C Diethyl Succinate

(2011) Niki M. Zacharias et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Release activation of iron oxide nanoparticles: (REACTION) A novel environmentally sensitive MRI paradigm

(2011) Dorit Granot et al.   MAGNETIC RESONANCE IN MEDICINE

A Tumor-Environment-Responsive Nanocarrier That Evolves Its Surface Properties upon Sensing Matrix Metalloproteinase-2 and Initiates Agglomeration to EnhanceT2Relaxivity for Magnetic Resonance Imaging

(2011) Sachiko Matsumura et al.   MOLECULAR PHARMACEUTICS

Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma

(2011) H. S. Venkatesh et al.   NEURO-ONCOLOGY

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-13C2]pyruvate in vivo

(2011) Albert P. Chen et al.   NMR IN BIOMEDICINE

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs)

(2011) Shann S Yu et al.   JOURNAL OF NANOBIOTECHNOLOGY

A Secreted Enzyme Reporter System for MRI

(2010) Gil G. Westmeyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes

(2010) Sara Figueiredo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

lacZas a genetic reporter for real-time MRI

(2010) Niclas E. Bengtsson et al.   MAGNETIC RESONANCE IN MEDICINE

Self-degrading, MRI-detectable hydrogel sensors with picomolar target sensitivity

(2010) Jason Colomb et al.   MAGNETIC RESONANCE IN MEDICINE

S-Gal®, A novel 1H MRI reporter for β-galactosidase

(2010) Weina Cui et al.   MAGNETIC RESONANCE IN MEDICINE

1H-MR Spectroscopy in Traumatic Brain Injury

(2010) Silvia Marino et al.   Neurocritical Care

A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies

(2010) Mojmír Suchý et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Imaging β-Galactosidase Activity in Human Tumor Xenografts and Transgenic Mice Using a Chemiluminescent Substrate

(2010) Li Liu et al.   PLoS One

Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate

(2009) Magnus Karlsson et al.   INTERNATIONAL JOURNAL OF CANCER

New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging

(2009) Beata Jastrzȩbska et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Nanoparticles Engineered to Sense Kinase Activity in MRI

(2009) Mikhail G. Shapiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperpolarized [2-13C]-Fructose: A Hemiketal DNP Substrate for In Vivo Metabolic Imaging

(2009) Kayvan R. Keshari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activatable Magnetic Resonance Imaging Agents for Myeloperoxidase Sensing: Mechanism of Activation, Stability, and Toxicity

(2009) Elisenda Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperpolarized13C magnetic resonance detection of carboxypeptidase G2 activity

(2009) Yann Jamin et al.   MAGNETIC RESONANCE IN MEDICINE

Bioluminescence imaging of myeloperoxidase activity in vivo

(2009) Shimon Gross et al.   NATURE MEDICINE

An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

(2009) Byunghee Yoo et al.   TETRAHEDRON LETTERS

Detection of Enzymatic Activity by PARACEST MRI: A General Approach to Target a Large Variety of Enzymes

(2008) Thomas Chauvin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protease-Specific Nanosensors for Magnetic Resonance Imaging

(2008) Eyk Schellenberger et al.   BIOCONJUGATE CHEMISTRY

Current and Potential Applications of Clinical 13C MR Spectroscopy

(2008) J. Kurhanewicz et al.   JOURNAL OF NUCLEAR MEDICINE

Molecular Imaging of Hypoxia

(2008) K. A. Krohn et al.   JOURNAL OF NUCLEAR MEDICINE

New “multicolor” polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI

(2008) Michael T. McMahon et al.   MAGNETIC RESONANCE IN MEDICINE

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized13C-labeled glutamine

(2008) Ferdia A. Gallagher et al.   MAGNETIC RESONANCE IN MEDICINE

Whole-body imaging at 7T: Preliminary results

(2008) J. Thomas Vaughan et al.   MAGNETIC RESONANCE IN MEDICINE

A19F-NMR approach using reporter molecule pairs to assessβ-galactosidase in human xenograft tumorsin vivo

(2008) Jian-Xin Yu et al.   NMR IN BIOMEDICINE

An overview of responsive MRI contrast agents for molecular imaging

(2007) Byunghee Yoo   Frontiers in Bioscience-Landmark

Paramagnetic Relaxation-Based19F MRI Probe To Detect Protease Activity

(2007) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY