Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity

(2020) Alejandro Luarte et al.   Cells

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease

(2019) Brendan P. Lucey et al.   Science Translational Medicine

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

(2019) Raquel Pascua-Maestro et al.   Frontiers in Cellular Neuroscience

The emerging role of exosomes in mental disorders

(2019) Saumeh Saeedi et al.   Translational Psychiatry

Extracellular Vesicle as a Source of Alzheimer’s Biomarkers: Opportunities and Challenges

(2019) Seongju Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease

(2019) Luke S. Watson et al.   Molecular Neurodegeneration

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

(2019) Phuong H. L. Tran et al.   ADVANCED MATERIALS

Propagation of Tau via Extracellular Vesicles

(2019) Mar Pérez et al.   Frontiers in Neuroscience

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

(2019) Yuqin Men et al.   Nature Communications

Role of Exosomes in Central Nervous System Diseases

(2019) Wanying Liu et al.   Frontiers in Molecular Neuroscience

Mechanisms of nuclear content loading to exosomes

(2019) Akira Yokoi et al.   Science Advances

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers

(2018) Rama Rao Malla et al.   Asia-Pacific Journal of Clinical Oncology

Microglia-derived extracellular vesicles in Alzheimer’s Disease: A double-edged sword

(2018) Teresa Trotta et al.   BIOCHEMICAL PHARMACOLOGY

Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel

(2018) Jessica Gill et al.   BRAIN INJURY

Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Exosomal biomarkers in Down syndrome and Alzheimer's disease

(2018) Eric D. Hamlett et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuron-Related Blood Inflammatory Markers as an Objective Evaluation Tool for Major Depressive Disorder: An Exploratory Pilot Case-Control Study

(2018) Nobuki Kuwano et al.   JOURNAL OF AFFECTIVE DISORDERS

Autophagy regulates exosomal release of prions in neuronal cells

(2018) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multipotent mesenchymal stromal cell–derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat

(2018) Yuxia Han et al.   JOURNAL OF NEUROSURGERY

Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock

(2018) Aaron M Williams et al.   JOURNAL OF NEUROTRAUMA

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

(2018) Qingfu Zhu et al.   LAB ON A CHIP

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

(2018) Robin L. Webb et al.   STROKE

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

(2018) André M. Miranda et al.   Nature Communications

Effect of young exosomes injected in aged mice

(2018) Bo-Ram Lee et al.   International Journal of Nanomedicine

Increasing the Predictive Accuracy of Amyloid-β Blood-Borne Biomarkers in Alzheimer's Disease

(2018) Andrew D. Watt et al.   JOURNAL OF ALZHEIMERS DISEASE

A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer's Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls

(2018) Sébastien S. Hébert et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteins Recruited to Exosomes by Tau Overexpression Implicate Novel Cellular Mechanisms Linking Tau Secretion with Alzheimer's Disease

(2018) Sudad Saman et al.   JOURNAL OF ALZHEIMERS DISEASE

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease

(2018) Mao Ding et al.   NEUROCHEMICAL RESEARCH

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

(2018) Frank F. Heisler et al.   NEURON

Progression of Alzheimer’s disease, tau propagation, and its modifiable risk factors

(2018) Shuko Takeda   NEUROSCIENCE RESEARCH

A Comparison of Traditional and Novel Methods for the Separation of Exosomes from Human Samples

(2018) Li-Li Yu et al.   Biomed Research International

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

(2018) Claudia Cicognola et al.   ACTA NEUROPATHOLOGICA

Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons

(2018) Antonella Raffo-Romero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small extracellular vesicles in rat serum contain astrocyte-derived protein biomarkers of repetitive stress

(2018) Cristóbal Gómez-Molina et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

(2018) Charisse N. Winston et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

(2018) Nisim Perets et al.   Molecular Autism

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

(2017) Roger J. Mullins et al.   HUMAN BRAIN MAPPING

Sphingolipid-Enriched Extracellular Vesicles and Alzheimer’s Disease: A Decade of Research

(2017) Michael B. Dinkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of Gβγ subunits of Giprotein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes

(2017) Taketoshi Kajimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage

(2017) Laura Otero-Ortega et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

(2017) Annina M. DeLeo et al.   Journal of Neuroimmune Pharmacology

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury

(2017) Yanlu Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

(2017) Qianfa Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

(2017) Robin L. Webb et al.   Translational Stroke Research

Exosomes as Carriers of Alzheimer's Amyloid-ß

(2017) Kohei Yuyama et al.   Frontiers in Neuroscience

Exosomes and the Prion Protein: More than One Truth

(2017) Alexander Hartmann et al.   Frontiers in Neuroscience

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

(2017) Francesco Drago et al.   Frontiers in Pharmacology

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

(2017) Junichi Matsumoto et al.   Acta Neuropathologica Communications

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity

(2016) S. Sarkar et al.   BRAIN RESEARCH

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein

(2016) Kathrin Guitart et al.   GLIA

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells

(2016) Sandra Atienzar-Aroca et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

(2016) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

(2016) Mark Cohen et al.   Prion

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

(2016) Sylwia Koniusz et al.   Frontiers in Cellular Neuroscience

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

(2016) Daan R.M.G. Ophelders et al.   Stem Cells Translational Medicine

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

(2016) Erin L. Abner et al.   Annals of Clinical and Translational Neurology

Plasma microRNA biomarkers for detection of mild cognitive impairment

(2016) Kira S. Sheinerman et al.   Aging-US

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485Phosphorylation

(2015) Bhumsoo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

(2015) Ismael Santa-Maria et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

(2015) Fatemeh Momen-Heravi et al.   Journal of Translational Medicine

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

(2015) Insaf Bahrini et al.   Scientific Reports

Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets

(2014) Pierre Lau et al.   AGEING RESEARCH REVIEWS

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin

(2014) Xia Xiao et al.   PLoS One

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

(2014) Kasandra Burgos et al.   PLoS One

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

(2014) Robert Brunkhorst et al.   Frontiers in Cellular Neuroscience

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies

(2013) Z. Song et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Exosomes function in cell–cell communication during brain circuit development

(2013) Pranav Sharma et al.   CURRENT OPINION IN NEUROBIOLOGY

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

(2013) Chiara Corrado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

More than Cell Dust: Microparticles Isolated from Cerebrospinal Fluid of Brain Injured Patients Are Messengers Carrying mRNAs, miRNAs, and Proteins

(2013) Silke Patz et al.   JOURNAL OF NEUROTRAUMA

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

(2013) Gary P. Morris et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

(2013) Kyongman An et al.   Molecular Brain

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Extracellular vesicles - vehicles that spread cancer genes

(2012) Janusz Rak et al.   BIOESSAYS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Changes in circulating microRNA levels associated with prostate cancer

(2012) R J Bryant et al.   BRITISH JOURNAL OF CANCER

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

(2012) A. S. Chen-Plotkin et al.   JOURNAL OF NEUROSCIENCE

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

(2012) M. Lucrecia Alvarez et al.   KIDNEY INTERNATIONAL

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Spreading of Alzheimer’s disease inflammatory signaling through soluble micro-RNA

(2012) Walter J. Lukiw et al.   NEUROREPORT

Emerging Role of Neuronal Exosomes in the Central Nervous System

(2012) Mathilde Chivet et al.   Frontiers in Physiology

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

(2011) Hirosha Geekiyanage et al.   EXPERIMENTAL NEUROLOGY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

(2011) Leo Timmers et al.   Stem Cell Research

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Prion protein and Alzheimer disease

(2010) Katherine A.B. Kellett et al.   Prion

Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages

(2010) Pramod K. Giri et al.   PROTEOMICS

MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

(2010) Albert H. Kim et al.   SCHIZOPHRENIA RESEARCH

Wnt1-cre-mediated Conditional Loss of Dicer Results in Malformation of the Midbrain and Cerebellum and Failure of Neural Crest and Dopaminergic Differentiation in Mice

(2010) Tianwen Huang et al.   Journal of Molecular Cell Biology

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system

(2009) Yoko Kawase-Koga et al.   DEVELOPMENTAL DYNAMICS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Exosomes Derived from M. Bovis BCG Infected Macrophages Activate Antigen-Specific CD4+ and CD8+ T Cells In Vitro and In Vivo

(2008) Pramod K. Giri et al.   PLoS One

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

A microRNA-based gene dysregulation pathway in Huntington's disease

(2007) Rory Johnson et al.   NEUROBIOLOGY OF DISEASE