Role of Exosomes in Central Nervous System Diseases

Potential biomarkers to detect traumatic brain injury by the profiling of salivary extracellular vesicles

(2019) Yan Cheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease

(2019) Dilan Athauda et al.   JAMA Neurology

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease

(2019) Joseph O. Ojo et al.   Frontiers in Neuroscience

The spleen may be an important target of stem cell therapy for stroke

(2019) Zhe Wang et al.   Journal of Neuroinflammation

Noncoding RNAs and intracerebral hemorrhage

(2019) Lingzhi Li et al.   CNS & Neurological Disorders-Drug Targets

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Noninvasive Assessment of Fetal Central Nervous System Insult: Potential Application to Prenatal Diagnosis

(2019) Laura Goetzl et al.   PRENATAL DIAGNOSIS

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

(2019) Min Shi et al.   PROGRESS IN NEUROBIOLOGY

Modified Exosomes Reduce Apoptosis and Ameliorate Neural Deficits Induced by Traumatic Brain Injury

(2018) Bo Wang et al.   ASAIO JOURNAL

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury

(2018) Kimbra Kenney et al.   BRAIN INJURY

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Diagnosis of Hyperacute and Acute Ischaemic Stroke: The Potential Utility of Exosomal MicroRNA-21-5p and MicroRNA-30a-5p

(2018) Wei Wang et al.   CEREBROVASCULAR DISEASES

miR-7 Replacement Therapy in Parkinson’s Disease

(2018) Ricardo Titze-de-Almeida et al.   CURRENT GENE THERAPY

Fed-EXosome: extracellular vesicles and cell–cell communication in metabolic regulation

(2018) Isabella Samuelson et al.   Essays in Biochemistry

Exosomes and extracellular vesicles: the path forward

(2018) Philip D. Stahl et al.   Essays in Biochemistry

An update on diagnostic and prognostic biomarkers for traumatic brain injury

(2018) Kevin K. Wang et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Dendritic cells and routing cargo into exosomes

(2018) Dario A Leone et al.   IMMUNOLOGY AND CELL BIOLOGY

Exosome-mediated amplification of endogenous brain repair mechanisms and brain and systemic organ interaction in modulating neurological outcome after stroke

(2018) Poornima Venkat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The splenic response to stroke: from rodents to stroke subjects

(2018) Hilary A. Seifert et al.   Journal of Neuroinflammation

Exosomes and their role in the intercellular trafficking of normal and disease associated prion proteins

(2018) Lesley Cheng et al.   MOLECULAR ASPECTS OF MEDICINE

Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment

(2018) Nicole Osier et al.   MOLECULAR NEUROBIOLOGY

Exosomes and their implications in central nervous system tumor biology

(2018) Oliver D. Mrowczynski et al.   PROGRESS IN NEUROBIOLOGY

Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases With Focus on Prion Diseases

(2018) Syed Zahid Ali Shah et al.   Frontiers in Aging Neuroscience

A Preliminary Report on Brain-Derived Extracellular Vesicle as Novel Blood Biomarkers for Sport-Related Concussions

(2018) Keisuke Kawata et al.   Frontiers in Neurology

Extracellular vesicles: translational challenges and opportunities

(2018) Hannah Clemmens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role of Exosomes/Extracellular Vesicles in Neural Signal Transduction

(2018) Hironori Kawahara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Platelet-derived extracellular vesicles in Huntington’s disease

(2018) Hélèna L. Denis et al.   JOURNAL OF NEUROLOGY

Neuronal Enriched Extracellular Vesicle Proteins as Biomarkers for Brain Traumatic Injury

(2018) Hanuma Kumar Karnati et al.   JOURNAL OF NEUROTRAUMA

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

(2018) Frank F. Heisler et al.   NEURON

Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease

(2018) Yuki Kitamura et al.   NEUROSCIENCE

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

(2018) Edwin E. Reza-Zaldivar et al.   Frontiers in Cellular Neuroscience

MicroRNA Alterations in the Brain and Body Fluids of Humans and Animal Prion Disease Models: Current Status and Perspectives

(2018) Eirini Kanata et al.   Frontiers in Aging Neuroscience

Role of Exosomes as a Treatment and Potential Biomarker for Stroke

(2018) Laura Otero-Ortega et al.   Translational Stroke Research

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke

(2018) Nadine Kerr et al.   Frontiers in Molecular Neuroscience

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

(2018) Claudia Cicognola et al.   ACTA NEUROPATHOLOGICA

Potential of Exosomes for the Treatment of Stroke

(2018) Shi-Bin Hong et al.   CELL TRANSPLANTATION

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

(2018) Liang Zhao et al.   Journal of Neuroinflammation

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

(2018) Takuma Ohmichi et al.   PARKINSONISM & RELATED DISORDERS

Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications

(2018) Ana-Maria Zagrean et al.   Frontiers in Neuroscience

Extracellular Vesicles: How Drug and Pathology Interfere With Their Biogenesis and Function

(2018) Daniela Cesselli et al.   Frontiers in Physiology

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients

(2018) Daniel Saucier et al.   BRAIN RESEARCH

microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

(2017) Loredana Leggio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy

(2017) Hamed Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

(2017) Annina M. DeLeo et al.   Journal of Neuroimmune Pharmacology

Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

(2017) Rachna Manek et al.   MOLECULAR NEUROBIOLOGY

Emerging potential of exosomes for treatment of traumatic brain injury

(2017) Ye Xiong et al.   Neural Regeneration Research

Differential protein expression in exosomal samples taken from trauma patients

(2017) Ron B. Moyron et al.   Proteomics Clinical Applications

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury

(2017) Yongxiang Yang et al.   Frontiers in Cellular Neuroscience

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

(2017) George K. Tofaris   Journal of Parkinsons Disease

Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets

(2017) James K. T. Wang et al.   Frontiers in Neuroscience

Exosomes and the Prion Protein: More than One Truth

(2017) Alexander Hartmann et al.   Frontiers in Neuroscience

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules

(2017) Greg Maguire   World Journal of Stem Cells

Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

(2016) Mijung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

(2016) Roberta Bonafede et al.   EXPERIMENTAL CELL RESEARCH

Impaired activation of ALS monocytes by exosomes

(2016) Lisa Zondler et al.   IMMUNOLOGY AND CELL BIOLOGY

The Diagnostic Value of Circulating Brain-specific MicroRNAs for Ischemic Stroke

(2016) Zhong-Bao Yang et al.   INTERNAL MEDICINE

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes in stroke pathogenesis and therapy

(2016) Zheng Gang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

(2016) Aaron D. Thome et al.   JOURNAL OF NEUROSCIENCE

MicroRNA abundance is altered in synaptoneurosomes during prion disease

(2016) Amrit S. Boese et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Circulating microRNAs as biomarkers in progressive multiple sclerosis

(2016) Julia Vistbakka et al.   Multiple Sclerosis Journal

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

(2016) Katarzyna Winek et al.   STROKE

Are prions transported by plasma exosomes?

(2016) Larisa Cervenakova et al.   TRANSFUSION AND APHERESIS SCIENCE

Exosomes in Parkinson’s Disease

(2016) Xiaoqing Wu et al.   Neuroscience Bulletin

Circulating microRNAs as biomarkers in progressive multiple sclerosis

(2016) Julia Vistbakka et al.   Multiple Sclerosis Journal

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche

(2016) Alejandro Luarte et al.   Stem Cells International

MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer’s disease

(2016) Gang Wang et al.   Scientific Reports

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

(2015) Pooja Joshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs

(2015) F. Collino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126

(2015) Fan Chen et al.   Translational Stroke Research

Forebrain neurocircuitry associated with human reflex cardiovascular control

(2015) J. Kevin Shoemaker et al.   Frontiers in Physiology

Cerebral Small Vessel Disease and Renal Function: Systematic Review and Meta-Analysis

(2015) Stephen D.J. Makin et al.   CEREBROVASCULAR DISEASES

Impact of proteinuria and glomerular filtration rate on risk of ischaemic and intracerebral hemorrhagic stroke: a result from the Kailuan study

(2014) Z. Li et al.   EUROPEAN JOURNAL OF NEUROLOGY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Exosome platform for diagnosis and monitoring of traumatic brain injury

(2014) D. D. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery of Prognostic Biomarker Candidates of Lacunar Infarction by Quantitative Proteomics of Microvesicles Enriched Plasma

(2014) Arnab Datta et al.   PLoS One

Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study

(2014) Danny A Kanhai et al.   BMJ Open

Comparison of Associations of Outcomes After Stroke With Estimated GFR Using Chinese Modifications of the MDRD Study and CKD-EPI Creatinine Equations: Results From the China National Stroke Registry

(2013) Xianwei Wang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Systems Approach to Neurodegenerative Disease Biomarker Discovery

(2013) Christopher Lausted et al.   Annual Review of Pharmacology and Toxicology

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION