Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

(2013) Iftach Dolev et al.   NATURE NEUROSCIENCE

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain

(2011) Wen-Quan Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

The cellular prion protein and its role in Alzheimer disease

(2010) J. L. Velayos et al.   Prion

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of phe19 and phe20 on fibril formation by amyloidogenic peptide Aβ16-22 (Ac-KLVFFAE-NH2)

(2010) Hideyo Inouye et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

(2008) Sandrine Alais et al.   BIOLOGY OF THE CELL

Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils

(2008) Takuma Okada et al.   JOURNAL OF MOLECULAR BIOLOGY

Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation

(2008) Kohei Yuyama et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Exosomes: The Trojan horses of neurodegeneration

(2008) Roberta Ghidoni et al.   MEDICAL HYPOTHESES

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY