Article
Nutrition & Dietetics
Ryszard Pluta, Wanda Furmaga-Jablonska, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: Curcumin, a natural polyphenolic compound, has pleiotropic biological properties and can regulate changes in the brain after ischemia and neurodegenerative diseases. It can prevent the aggregation and insolubility of aging-related proteins, and reduce neurotoxicity. Animal models of cerebral ischemia have demonstrated that curcumin can reduce various pathological changes and improve neurological and behavioral deficits.
Article
Geriatrics & Gerontology
Sara Cazzaro, Cenxiao Fang, Hirah Khan, Richard Witas, Teresa R. Kee, Jung-A A. Woo, David E. Kang
Summary: The study reveals that cargo receptors Sqstm1/p62 and optineurin inhibit sEV secretion, which requires their ability to bind ubiquitinated cargo. In addition, increasing actin dynamics can also enhance sEV secretion. These findings provide a potential strategy to promote misfolded protein degradation and reduce sEV-mediated cell-to-cell spread of pathology.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Guimin Zheng, Lei Wang, Xiuqin Li, Xiaoli Niu, Guodong Xu, Peiyuan Lv
Summary: The study demonstrated that rapamycin can improve cognitive impairment in vascular dementia rats, alleviate neuronal injury, and mitigate mitochondrial dysfunction. Its mechanism of action may involve inhibiting neuronal apoptosis and enhancing mitophagy through the PI3K/AKT/mTOR pathway. These findings offer a promising possibility for a novel treatment strategy for vascular dementia.
Review
Biochemistry & Molecular Biology
Ryszard Pluta, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: This article highlights the neuroprotective effects of molecular hydrogen following ischemic brain injury, including its potential for improving cognitive and neurological deficits and preventing neurodegenerative changes. The study suggests that molecular hydrogen may be a promising therapeutic agent in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Ryszard Pluta, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: The review evaluated the potential dietary therapy with myricetin for post-ischemic neurodegeneration, highlighting its pleiotropic properties and potential as a promising candidate for treating neurodegenerative disorders. Myricetin is seen as a safe, commercially available, cost-effective substance, with evidence suggesting its therapeutic potential in the prevention and treatment of brain neurodegeneration caused by ischemia.
Article
Biochemistry & Molecular Biology
Alaa Abou Daher, Sahar Alkhansa, William S. Azar, Rim Rafeh, Hilda E. Ghadieh, Assaad A. Eid
Summary: Understanding the mechanisms behind diabetic nephropathy (DN) is crucial for developing effective treatments. The mTOR pathway has been identified as a key player in diabetes-induced kidney injury, through its involvement in insulin resistance, oxidative stress, and autophagy regulation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Clinical Neurology
Michael S. Pollanen, Sylvester Onzivua, Paul M. McKeever, Janice Robertson, Ian R. Mackenzie, Gabor G. Kovacs, Francis Olwa, David L. Kitara, Amanda Fong
Summary: This article describes the clinicopathologic spectrum of nodding syndrome in northern Uganda. All 16 cases had chronic seizures, and seven cases also had progressive cognitive, behavioural, and motor decline. The main neuropathologic findings included tau pathology, cerebellar degeneration, and white matter degeneration.
Review
Cell Biology
Alejandro R. Roda, Gabriel Serra-Mir, Laia Montoliu-Gaya, Lidia Tiessler, Sandra Villegas
Summary: Alzheimer's disease is a neurodegenerative disease characterized by abnormal accumulation of amyloid-beta and tau proteins. While amyloid-beta accumulation may initiate the pathology, tau protein impairment is likely the main mediator of neurodegeneration. Factors such as the immune system and specific genes are implicated in both amyloid-beta and tau pathologies, and combined therapies targeting both proteins have been proposed as a strategy to stop disease progression.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb
Summary: This study reveals that Cx3cr1 deficiency impairs the uptake and degradation of A beta by microglia, leading to increased accumulation of neurotoxic A beta species. Additionally, the loss of Cx3cr1 results in dysfunctional microglia characterized by dampened TGF beta signaling, increased oxidative stress responses, and dysregulated pro-inflammatory activation. These findings highlight the significant role of Cx3cr1 in modulating neurodegeneration and cognitive function.
MOLECULAR NEURODEGENERATION
(2022)
Article
Clinical Neurology
Maryam Ghahremani, Meng Wang, Hung-Yu Chen, Henrik Zetterberg, Eric Smith, Zahinoor Ismail
Summary: This study investigated the association between mild behavioral impairment (MBI) and plasma p-tau181 levels, cognitive function changes, and the risk of developing Alzheimer's disease (AD). The findings showed that compared to individuals with no behavioral symptoms, those with MBI had higher levels of p-tau181, which was associated with declined memory and executive function, and an increased risk of developing AD.
Editorial Material
Cell Biology
Julian M. Carosi, Timothy J. Sargeant
Summary: The potential use of rapamycin for treating Alzheimer's disease has been studied, suggesting promise for early prevention but limited effectiveness in resolving existing pathology. The impact of lysosomal degradative capacity on rapamycin's effectiveness in Alzheimer's treatment needs further investigation.
Article
Neurosciences
Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri
Summary: This study investigated the association between the severity of neuropsychiatric symptoms (NPS) and Alzheimer's disease (AD) biomarkers (Aβ, p-tau, and HR) in order to characterize MCI patients with a poor prognosis. The results showed that only MCI patients with severe NPS had a lower hippocampal volume ratio (HR), indicating more pronounced medio-temporal atrophy. Future longitudinal studies are needed to further understand the relevance of this finding.
Article
Oncology
Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Summary: The study demonstrated that rapamycin protects against aristolochic acid-induced nephropathy by activating the mTOR-autophagy axis. This finding provides evidence for rapamycin as a promising pharmacological target for the treatment of aristolochic acid nephropathy.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Andrea Perez-Iturralde, Beatriz Carte, Rafael Aldabe
Summary: The study found that mTOR inhibitors have complex effects on AAV hepatic transduction efficiency, with rapamycin enhancing AAV transduction while RapaLink-1 and MLN0128 do not. This indicates that mTOR inhibition is not a straightforward strategy for improving AAV transduction, and more research is needed to elucidate the mechanisms involved in their effects.
HUMAN GENE THERAPY
(2021)
Article
Clinical Neurology
Sigrid Klotz, Gerda Ricken, Matthias Preusser, Karin Dieckmann, Georg Widhalm, Karl Rossler, Peter Fischer, Ognian Kalev, Adelheid Wohrer, Gabor G. Kovacs, Ellen Gelpi
Summary: Neurodegenerative diseases pose a significant health burden, and their underlying mechanisms are not fully understood. This study found enhanced autophagy and deposition of neurodegeneration-associated proteins within and around glioblastoma tumor cells, suggesting a preexisting neurodegenerative pathology rather than a tumor-induced condition.
Article
Behavioral Sciences
Luke S. Watson, Tyler D. Stone, Dominique Williams, Alexus S. Williams, Catrina Sims-Robinson
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Eric D. Hamlett, Erik Hjorth, Aurelie Ledreux, Anah Gilmore, Marianne Schultzberg, Ann Charlotte Granholm
Article
Neurosciences
L. Lemoine, A. Ledreux, E. J. Mufson, S. E. Perez, G. Simic, E. Doran, I. Lott, S. Carroll, K. Bharani, S. Thomas, A. Gilmore, E. D. Hamlett, A. Nordberg, A. C. Granholm
MOLECULAR NEURODEGENERATION
(2020)
Article
Medicine, General & Internal
Aurelie Ledreux, Sarah Thomas, Eric D. Hamlett, Camille Trautman, Anah Gilmore, Emily Rickman Hager, Daniel A. Paredes, Martin Margittai, Juan Fortea, Ann-Charlotte Granholm
Summary: Individuals with Down syndrome exhibit Alzheimer's disease pathology at a young age, including amyloid plaques and neurofibrillary tangles. Tau pathology can spread via extracellular vesicles, and NDEVs from individuals with DS-AD have been found to contain p-Tau. Transferring NDEVs from DS-AD patients into wildtype mice resulted in the spread of Tau pathology in the brain, demonstrating that these vesicles have Tau seeding capacity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Pengfei Li, Yan Wu, Eric D. Hamlett, Andrew J. Goodwin, Perry Halushka, Steven L. Carroll, Meng Liu, Hongkuan Fan
Summary: The transcription factor Fli-1 plays a role in the loss of pericytes, inflammatory response, AD deposition, vascular dysfunction, and cognitive decline in AD. Inhibition of Fli-1 may represent a novel therapeutic strategy for AD.
Article
Medicine, General & Internal
Zhenwu Luo, Sylvia Fitting, Catrina Robinson, Andreana Benitez, Min Li, Yongxia Wu, Xiaoyu Fu, Davide Amato, Wangbin Ning, Nicholas Funderburg, Xu Wang, Zejun Zhou, Xuezhong Yu, Amanda Wagner, Xiaomei Cong, Wanli Xu, Kendra Maas, Bethany J. Wolf, Lei Huang, Jeremy Yu, Alison Scott, Aimee Mcrae-Clark, Eric D. Hamlett, Wei Jiang
Summary: This study revealed that chronic cannabis smoking may lead to oral microbial dysbiosis, resulting in enrichment of Actinomyces meyeri and its association with CNS abnormalities.
Article
Clinical Neurology
Andreana Benitez, Jens H. Jensen, Kathryn Thorn, Siddhartha Dhiman, Stephanie Fountain-Zaragoza, William J. Rieter, Maria Vittoria Spampinato, Eric D. Hamlett, Paul J. Nietert, Maria de Fatima Falangola, Joseph A. Helpern
Summary: This study aimed to detect and describe amyloid-related white matter changes in preclinical Alzheimer's disease using diffusional kurtosis imaging (DKI) and biophysical modeling. The results showed greater diffusion restriction in white matter, particularly in the extra-axonal space within late myelinating tracts, in Alzheimer's disease patients. The diffusion metrics were able to predict amyloid status incrementally and were associated with other biomarkers.
ANNALS OF NEUROLOGY
(2022)
Review
Neurosciences
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson
Summary: Ischemic stroke and traumatic brain injury are major causes of death and disability worldwide, and neurotrophic factors play a crucial role in promoting neural repair and recovery. However, the translation of these factors from preclinical to clinical trials has been challenging.
Article
Neurosciences
Sophie Dutheil, Luke S. Watson, Robert E. Davis, Gretchen L. Snyder
Summary: Lumateperone is approved for the treatment of schizophrenia and bipolar depression in adults. It acts by modulating serotonin, dopamine, and glutamate neurotransmission. Preclinical studies suggest that it may also have anti-inflammatory effects and regulate genes/pathways involved in tissue integrity and blood-brain barrier function.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Eric D. Hamlett, Lisi Flores-Aguilar, Benjamin Handen, Marie-Claude Potier, Ann-Charlotte Granholm, Stephanie Sherman, Victoria Puig, Jonathan D. Santoro, Maria Carmona-Iragui, Anne-Sophie Rebillat, Elizabeth Head, Andre Strydom, Jorge Busciglio
Summary: Research on Down syndrome has been gaining momentum in recent years, providing a better understanding of how trisomy 21 modifies molecular and cellular processes. The Trisomy 21 Research Society (T21RS) is a leading scientific organization for researchers and clinicians studying Down syndrome. During the COVID pandemic, T21RS held its first virtual conference, bringing together 342 scientists, families, and industry representatives from over 25 countries to share the latest discoveries and therapeutic approaches related to T21.
MOLECULAR SYNDROMOLOGY
(2023)
Editorial Material
Clinical Neurology
Melanie W. Gail, Catrina Sims-Robinson, Heather Boger, Adviye Ergul, Rupak Mukherjee, Dorothea D. Jenkins, Mark S. George
Article
Biochemistry & Molecular Biology
Stephanie G. Dilucia, B. Jacob Kendrick, Catrina Sims-Robinson
Summary: Insulin signaling plays a crucial role in maintaining adequate cerebral perfusion. However, hyperinsulinemia disrupts the internalization of insulin receptor, impairs nitric oxide synthase activation, and dysregulates phosphorylation of key effectors involved in endocytosis. This study highlights the detrimental impact of hyperinsulinemia on brain endothelial cells' ability to regulate blood flow.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Crystal J. Smith, Serena-Kaye Sims, Stacy Nguyen, Alexus Williams, Taylor McLeod, Catrina Sims-Robinson
Summary: Obesity is associated with increased stroke risk and worse post-stroke outcomes, but the underlying mechanisms are not well understood. This study aimed to investigate the potential impact of brain insulin deficiency on post-stroke outcomes.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Luke S. Watson, Brynna Wilken-Resman, Alexus Williams, Stephanie DiLucia, Guadalupe Sanchez, Taylor L. McLeod, Catrina Sims-Robinson
Summary: Hyperinsulinemia affects the internalization of insulin receptors in brain endothelial cells. Under high insulin levels, the signaling of insulin receptors is weakened while the receptor levels increase. PTP1B plays a role in regulating this process. This study provides insights into the mechanism of insulin receptor internalization.
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
