Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

Prion-like Spreading in Tauopathies

(2018) Jacob I. Ayers et al.   BIOLOGICAL PSYCHIATRY

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

(2017) Patrick Reilly et al.   NEUROBIOLOGY OF DISEASE

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Diagnostic Potential of Neural Exosome Cargo as Biomarkers for Acute Brain Injury

(2017) Laura Goetzl et al.   Annals of Clinical and Translational Neurology

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Q&A: What are exosomes, exactly?

(2016) James R. Edgar   BMC BIOLOGY

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

(2016) Robert A. Stern et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

(2014) Simon Dujardin et al.   Acta Neuropathologica Communications

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function

(2013) Adam W. Oaks et al.   PLoS One

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice

(2013) Nadine A Hoffmann et al.   Acta Neuropathologica Communications

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

(2012) Brian Spencer et al.   MOLECULAR THERAPY

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration

(2011) Tomasz Jaworski et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells

(2011) Shauna H. Yuan et al.   PLoS One

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY