Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

(2019) Jianmei Zou et al.   ANALYTICAL CHEMISTRY

In Vitro Selection of a DNA Aptamer by Cell-SELEX as a Molecular Probe for Cervical Cancer Recognition and Imaging

(2019) Jine Wang et al.   JOURNAL OF MOLECULAR EVOLUTION

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

(2019) Dnyaneshwar Kalyane et al.   Materials Science & Engineering C-Materials for Biological Applications

Distinct shed microvesicle and exosome microRNA signatures reveal diagnostic markers for colorectal cancer

(2019) Maoshan Chen et al.   PLoS One

Development of DNA Aptamers to Native EpCAM for Isolation of Lung Circulating Tumor Cells from Human Blood

(2019) Galina Zamay et al.   Cancers

A Detailed Protein-SELEX Protocol Allowing Visual Assessments of Individual Steps for a High Success Rate

(2019) Tao Wang et al.   Human Gene Therapy Methods

Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Cancer Targeted Therapy

(2019) Fang Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs

(2019) Phuong H.L. Tran et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

(2019) Lin Song et al.   Nature Communications

Differential binding cell-SELEX method to identify cell-specific aptamers using high-throughput sequencing

(2019) Karlis Pleiko et al.   Scientific Reports

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates

(2019) Koita Sacko et al.   Nanomaterials

Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers

(2018) Gang Zhou et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

(2018) Shabanali Khodashenas Limoni et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum

(2018) Sunil K. Arya et al.   BIOSENSORS & BIOELECTRONICS

Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity

(2018) Xiao-qian Dou et al.   International Journal of Nanomedicine

RNA Aptamer Delivery through Intact Human Skin

(2018) Jon D. Lenn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nanoparticles with CD44 Targeting and ROS Triggering Properties as Effective in Vivo Antigen Delivery System

(2018) Xiaoyu Liang et al.   MOLECULAR PHARMACEUTICS

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tunable cytotoxic aptamer–drug conjugates for the treatment of prostate cancer

(2018) Bethany Powell Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

(2018) Maggie K. S. Tang et al.   Nature Communications

Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion

(2018) Joshua S. Brzozowski et al.   Scientific Reports

An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells

(2018) Mostak Ahmed et al.   Biomaterials Science

STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

(2018) Carla Lucia Esposito et al.   Molecular Therapy-Nucleic Acids

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

(2018) Sunyoung Ham et al.   Frontiers in Immunology

Graphene nanocomposites modified electrochemical aptamer sensor for rapid and highly sensitive detection of prostate specific antigen

(2018) Bo Wei et al.   BIOSENSORS & BIOELECTRONICS

Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

(2018) N. L. Fletcher et al.   CHEMICAL COMMUNICATIONS

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

In vivo SELEX of bone targeting aptamer in prostate cancer bone metastasis model

(2018) Lingxiao Chen et al.   International Journal of Nanomedicine

Recent advancements in the use of exosomes as drug delivery systems

(2018) Edwin J. Bunggulawa et al.   JOURNAL OF NANOBIOTECHNOLOGY

Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting

(2018) Yuanyuan Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma

(2018) Sorah Yoon et al.   Molecular Therapy-Nucleic Acids

A TIM-3 Oligonucleotide Aptamer Enhances T Cell Functions and Potentiates Tumor Immunity in Mice

(2017) Tal Gefen et al.   MOLECULAR THERAPY

Aptamer-Targeted Attenuation of IL-2 Signaling in CD8 + T Cells Enhances Antitumor Immunity

(2017) Anugraha Rajagopalan et al.   MOLECULAR THERAPY

Development of Cell-Specific Aptamers: Recent Advances and Insight into the Selection Procedures

(2017) Kamal Rahimizadeh et al.   MOLECULES

Size dependent targeted delivery of gold nanoparticles modified with the IL-6R-specific aptamer AIR-3A to IL-6R-carrying cells

(2017) Lisa Prisner et al.   Nanoscale

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

(2017) Nicholas L. Syn et al.   TRENDS IN BIOTECHNOLOGY

Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery

(2017) Dongxi Xiang et al.   Theranostics

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

(2017) Grace Truong et al.   PLoS One

Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells

(2017) Hadi AlShamaileh et al.   Scientific Reports

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Multifunctional Transmembrane Protein Ligands for Cell-Specific Targeting of Plasma Membrane-Derived Vesicles

(2016) Chi Zhao et al.   Small

Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity

(2016) Joanna Macdonald et al.   Nucleic Acid Therapeutics

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples

(2016) Galina S. Zamay et al.   Scientific Reports

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

(2015) Dongxi Xiang et al.   Theranostics

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

(2015) Dongxi Xiang et al.   Theranostics

EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model

(2015) Tao Wang et al.   Theranostics

Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing

(2015) Rebecca E. Lane et al.   Scientific Reports

Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

(2014) Walhan Alshaer et al.   BIOCONJUGATE CHEMISTRY

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Probing the Coagulation Pathway with Aptamers Identifies Combinations that Synergistically Inhibit Blood Clot Formation

(2014) Kristin M. Bompiani et al.   CHEMISTRY & BIOLOGY

Functionalized nanofibers as drug-delivery systems for osteochondral regeneration

(2014) Evžen Amler et al.   Nanomedicine

An aptasensor for electrochemical detection of tumor necrosis factor in human blood

(2013) Ying Liu et al.   ANALYST

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

The Use of Sensitive Chemical Antibodies for Diagnosis: Detection of Low Levels of Epcam in Breast Cancer

(2013) Sarah Shigdar et al.   PLoS One

RNA aptamers targeting cancer stem cell marker CD133

(2012) Sarah Shigdar et al.   CANCER LETTERS

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

(2011) Sarah Shigdar et al.   CANCER SCIENCE

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Mammalian cell transfection: the present and the future

(2010) Tae Kyung Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION