Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Wei Yang, Cao Chen, Jia Chen, Ying Xia, Chao Hu, Lin Wang, Yue-Zhang Wu, Qi Shi, Zhi-Bao Chen, Xiao-Ping Dong
Summary: This study evaluated the effects of 3,4-dihydroxybenzalacetone (DBL) on prion-infected cells and found that DBL can decrease PrPSc levels, activate cellular protective mechanisms, and alleviate cellular stress and dysfunction. These findings suggest that DBL has potential as a therapeutic agent for prion diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui, Pei Jiang
Summary: Autophagy is a dynamic process that maintains cell homeostasis by digesting proteins and organelles. Its effect on neural tissue is debated, with some suggesting a protective role and others suggesting it can induce cell death. Oxidative stress, autophagy, and endoplasmic reticulum stress (ERS) are important defense mechanisms in cells under stress. They are integrated and amplified in pathophysiological conditions to promote disease progression. The interactions between oxidative stress, autophagy and ERS in neuronal cell death and survival are reviewed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Malgorzata Zatyka, Tatiana R. Rosenstock, Congxin Sun, Adina M. Palhegyi, Georgina W. Hughes, Samuel Lara-Reyna, Dewi Astuti, Alessandro di Maio, Axel Sciauvaud, Miriam E. Korsgen, Vesna Stanulovic, Gamze Kocak, Malgorzata Rak, Sandra Pourtoy-Brasselet, Katherine Winter, Thiago Varga, Margot Jarrige, Helene Polveche, Joao Correia, Eva-Maria Frickel, Maarten Hoogenkamp, Douglas G. Ward, Laetitia Aubry, Timothy Barrett, Sovan Sarkar
Summary: Wolfram syndrome (WS) is a rare early-onset neurodegenerative disease that is associated with mitochondrial abnormalities. The loss of interaction between WFS1 and VDAC1 in WS cells can compromise mitochondrial function, but restoring WFS1 levels can improve mitochondrial function and network. Therefore, targeting WFS1 or modulating mitochondrial function may provide a therapeutic intervention for WS and similar diseases.
Article
Biochemistry & Molecular Biology
Jianguo Liu, Rendong Qiu, Ran Liu, Pengjie Song, Pengfei Lin, Huatao Chen, Dong Zhou, Aihua Wang, Yaping Jin
Summary: This study found that primary bovine endometrial epithelial cells (bEECs) expressed an inflammatory response through the assembly of the NLRP3 inflammasome and activation of the NF-kappa B p65 subunit during Escherichia coli (E. coli) infection. E. coli infection also led to an abnormal increase in cytoplasmic calcium and mitochondrial dysfunction. The increase in cytosolic calcium was mainly caused by the release of calcium ions stored in the endoplasmic reticulum and mitochondria. Cytoplasmic calcium regulates mitochondrial respiratory chain transmission, DNA replication, and biogenesis. Activation of autophagy inhibited the release of inflammatory substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Elias Gebara, Olivia Zanoletti, Sriparna Ghosal, Jocelyn Grosse, Bernard L. Schneider, Graham Knott, Simone Astori, Carmen Sandi
Summary: The research suggests that the mitochondrial GTPase MFN2 in the NAc plays a crucial role in regulating anxiety and depression-like behaviors by impacting mitochondrial and MSN structure and function. Viral MFN2 overexpression in the NAc can reverse these behavioral and neuronal phenotypes changes.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Nasrin Abolhasanpour, Samin Alihosseini, Sevda Golipourkhalili, Reza Badalzadeh, Javad Mahmoudi, Leila Hosseini
Summary: Ischemic stroke leads to a cascade of cellular mechanisms in the brain, with melatonin showing beneficial effects in reducing oxidative stress, inflammation, and apoptosis. Studies suggest that melatonin therapy after stroke can improve mitochondrial dysfunction and alleviate ER stress and inflammation. The impact of melatonin on mitochondrial and ER function, as well as the crosstalk between the two organelles, is discussed as a therapeutic target for stroke.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Ronghui Fan, Senzhen Wang, Yalan Wu, Yongli Feng, Mengke Gao, Yue Cao, Xiaoxuan Ma, Songqiang Xie, Chaojie Wang, Lei Gao, Yanming Wang, Fujun Dai
Summary: This study aims to examine the effects of harmine on esophageal squamous cell carcinoma (ESCC) and its mechanism. The results showed that harmine inhibited the growth of ESCC cells and achieved this through regulation of endoplasmic reticulum stress. Therefore, harmine may be a promising candidate for the treatment of ESCC.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Thu-Ha Tran, Ming Kao, Hsiao-Sheng Liu, Yi-Ren Hong, Yeu Su, Chi-Ying F. Huang
Summary: In this study, it was found that the antipsychotic drug thioridazine (THD) could induce autophagy and immunogenic cell death (ICD) in colorectal cancer (CRC) cells. When combined with oxaliplatin (OXA), THD showed a remarkable ICD-activating effect to prevent tumor progression in a mouse model.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara
Summary: Exposure to methylmercury can induce oxidative and endoplasmic reticulum stress, leading to neuronal cell death. This study investigates the time course signaling alterations of the unfolded protein response (UPR) in the most affected brain areas, revealing a potential therapeutic target for treating neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Toxicology
Chang Liu, Rong Ju
Summary: Manganese (Mn) is a trace element involved in various physiological processes, but overexposure to Mn is associated with neurodegenerative disorders and neuronal apoptosis. The mechanisms of Mn-induced neuronal apoptosis include reactive oxygen species generation, neuroinflammation, protein accumulation, endoplasmic reticulum stress (ER stress), and autophagy. ER stress and autophagy both have dual roles in cell protection and injury, and their relationship in Mn-induced neurotoxicity is still unclear. This review discusses the mechanisms and connections between ER stress, autophagy, and apoptosis, providing a new perspective on Mn-induced neuronal apoptosis and neurodegenerative diseases.
TOXICOLOGICAL SCIENCES
(2023)
Review
Chemistry, Physical
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding
Summary: The immune system plays a vital role in the occurrence and development of cancer. Immunotherapy offers a promising approach to treat and cure cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells activates innate and adaptive immune responses by releasing tumor-associated antigens and damage-associated molecular patterns. This review summarizes the progress in using biomaterials to induce ICD and discusses their potential application in cancer immunotherapy.
Article
Environmental Sciences
Rulin Ma, Bei Li, Cheng Zhang, Rongrong Lei, Xiao Zhang, Chao Wang, Shun Zhang, Aiguo Wang
Summary: Research indicates that PBDE-47 damages thyroid tissues by triggering endoplasmic reticulum stress, apoptosis, and autophagy, and these changes can be reversed by 4-Phenylbutyric acid.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ting Zhang, Jie Lu, Ying Yao, Yanting Pang, Xiaomeng Ding, Meng Tang
Summary: This study aims to explore the importance of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-induced autophagy in CdTe QDs toxicity, and the different cell outcomes in normal cells and cancer cells. The results showed that CdTe QDs induce ROS generation and prolonged ER stress in normal human liver cells (L02), leading to apoptosis. In contrast, CdTe QDs activate protective cellular autophagy in human liver cancer cells (HepG2 cells), preventing apoptosis.
ENVIRONMENTAL POLLUTION
(2023)
