Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets

(2018) Santa Mammana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

(2018) Jie Tang et al.   NEUROCHEMICAL RESEARCH

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

(2017) Jingkao Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

(2017) Fei Mao et al.   Biomed Research International

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Toll-Interleukin 1 Receptor domain-containing adaptor protein positively regulates BV2 cell M1 polarization

(2016) Leilei Gong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging

(2016) Lara Ordoñez-Gutierrez et al.   JOURNAL OF ALZHEIMERS DISEASE

A systematic literature review on nurses’ and health care support workers’ experiences of caring for people with dementia on orthopaedic wards

(2016) Jubilee Moonga et al.   JOURNAL OF CLINICAL NURSING

Vitamin D2 suppresses amyloid-β 25–35 induced microglial activation in BV2 cells by blocking the NF-κB inflammatory signaling pathway

(2016) Suchismita Raha et al.   LIFE SCIENCES

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells: Identification, Purification, and Biological Characteristics

(2016) Bin Zhang et al.   Stem Cells International

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation

(2016) Xiao Li et al.   EBioMedicine

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

(2015) Serena Rubina Baglio et al.   Stem Cell Research & Therapy

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up

(2015) Arnaud François et al.   PLoS One

Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation

(2014) A. Das et al.   JOURNAL OF IMMUNOLOGY

Inflammation and Programmed Cell Death in Alzheimer’s Disease: Comparison of the Central Nervous System and Peripheral Blood

(2014) Beatrice Macchi et al.   MOLECULAR NEUROBIOLOGY

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Immunomodulatory Potential of Human Adipose Mesenchymal Stem Cells Derived Exosomes on in vitro Stimulated T Cells

(2014) Rebeca Blazquez et al.   Frontiers in Immunology

Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice

(2013) Hongna Yang et al.   PLoS One

Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury

(2013) Joan E Nichols et al.   Stem Cell Research & Therapy

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling

(2012) Aram Mokarizadeh et al.   IMMUNOLOGY LETTERS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: A study in APP mutant mice

(2011) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice

(2011) Melinda E. Lull et al.   PLoS One

Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities

(2011) Rebecca A. Pelekanos et al.   Stem Cell Research

Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain

(2010) Suqing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease

(2009) Lingfei Ruan et al.   Current Alzheimer Research

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

(2009) Tian Sheng Chen et al.   NUCLEIC ACIDS RESEARCH

Disease-modifying therapies in Alzheimer’s disease

(2008) Stephen Salloway et al.   Alzheimers & Dementia

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells

(2008) Mark L. Weiss et al.   STEM CELLS

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Aβ levels

(2006) E. Hellström-Lindahl et al.   NEUROBIOLOGY OF AGING