Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Taurine potentiates the anticonvulsive effect of the GABAA agonist muscimol and pentobarbital in the immature mouse hippocampus

(2019) Paula Winkler et al.   EPILEPSIA

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment

(2019) Lu-Lin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis

(2019) Allison R. Peterson et al.   NEUROSCIENCE

Microglial polarization: novel therapeutic mechanism against Alzheimer’s disease

(2019) Kai Yao et al.   INFLAMMOPHARMACOLOGY

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

(2019) Tiziana Bonifacino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Acute Activation of the CB1 Receptor in the Hippocampus Decreases Neurotoxicity and Prevents Spatial Memory Impairment in Rats Lesioned with β-Amyloid 25–35

(2019) Aleidy Patricio-Martínez et al.   NEUROSCIENCE

Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium

(2019) Nastaran Rahimi et al.   NEUROSCIENCE LETTERS

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity

(2019) Joana Gonçalves-Ribeiro et al.   Frontiers in Cellular Neuroscience

Role of astrocyte purinergic signaling in epilepsy

(2019) Ljiljana Nikolic et al.   GLIA

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

(2019) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

(2018) Balázs Pál   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha

(2018) Azadeh Kia et al.   GLIA

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

(2018) Cátia Gomes et al.   MOLECULAR NEUROBIOLOGY

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

(2018) Bhuvaneish T. Selvaraj et al.   Nature Communications

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

(2018) Eiji Kobayashi et al.   Scientific Reports

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

(2018) Sara R. Tanqueiro et al.   Frontiers in Pharmacology

Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death

(2018) Min Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

(2017) Yan Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

(2017) Carolina Cunha et al.   MOLECULAR NEUROBIOLOGY

Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models

(2017) I. Popova et al.   NEUROBIOLOGY OF DISEASE

Small conductance Ca 2+ -activated K + channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases

(2017) Birgit Honrath et al.   NEUROCHEMISTRY INTERNATIONAL

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival

(2017) Jordan Rose et al.   TOXICOLOGY

Mechanical stress activates NMDA receptors in the absence of agonists

(2017) Mohammad Mehdi Maneshi et al.   Scientific Reports

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

Synaptic Activity Protects Neurons Against Calcium-Mediated Oxidation and Contraction of Mitochondria During Excitotoxicity

(2017) Constanze Depp et al.   ANTIOXIDANTS & REDOX SIGNALING

A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine

(2017) Hongqiu Guo et al.   Scientific Reports

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

(2016) Jacqueline A. Hubbard et al.   EXPERIMENTAL NEUROLOGY

Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke

(2016) Ming-Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids

(2016) Angela Maria Amorini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy

(2016) Longze Sha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1

(2016) M. Gravel et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

(2016) Jan Albrecht et al.   NEUROCHEMICAL RESEARCH

The Epidemiology of Global Epilepsy

(2016) Anuradha Singh et al.   NEUROLOGIC CLINICS

Motor cortical function determines prognosis in sporadic ALS

(2016) Kazumoto Shibuya et al.   NEUROLOGY

Crucial role of astrocytes in temporal lobe epilepsy

(2016) C. Steinhäuser et al.   NEUROSCIENCE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

The Rise and Fall of the d -Serine-Mediated Gliotransmission Hypothesis

(2016) Herman Wolosker et al.   TRENDS IN NEUROSCIENCES

Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death

(2016) Yoshinori Mikami et al.   EBioMedicine

Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Matthew J. Fogarty et al.   Acta Neuropathologica Communications

Neuronal networks provide rapid neuroprotection against spreading toxicity

(2016) Andrew J. Samson et al.   Scientific Reports

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc− Mediates Aglycemic Neuronal Cell Death

(2015) Trista L. Thorn et al.   ASN Neuro

Sporadic and hereditary amyotrophic lateral sclerosis (ALS)

(2015) Senda Ajroud-Driss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Altered Functionality, Morphology, and Vesicular Glutamate Transporter Expression of Cortical Motor Neurons from a Presymptomatic Mouse Model of Amyotrophic Lateral Sclerosis

(2015) L. Saba et al.   CEREBRAL CORTEX

Taming Glutamate Excitotoxicity: Strategic Pathway Modulation for Neuroprotection

(2015) Ming Jia et al.   CNS DRUGS

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy

(2015) Shane Rowley et al.   NEUROBIOLOGY OF DISEASE

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis

(2015) Marco Milanese et al.   NEUROBIOLOGY OF DISEASE

GLT1 overexpression in SOD1G93A mouse cervical spinal cord does not preserve diaphragm function or extend disease

(2015) Ke Li et al.   NEUROBIOLOGY OF DISEASE

Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus

(2015) Cui Wang et al.   NEUROCHEMICAL RESEARCH

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes

(2015) Sébastien Sultan et al.   NEURON

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective

(2015) S. Williams et al.   NEUROSCIENCE

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation

(2015) Vikas Mishra et al.   Scientific Reports

Astrocyte Regulation of Synaptic Behavior

(2014) Nicola J. Allen   Annual Review of Cell and Developmental Biology

Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity

(2014) Plamena R. Angelova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Study on ATP concentration changes in cytosol of individual cultured neurons during glutamate-induced deregulation of calcium homeostasis

(2014) A. M. Surin et al.   BIOCHEMISTRY-MOSCOW

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Network-wide dysregulation of calcium homeostasis in Alzheimer’s disease

(2014) Bianca Brawek et al.   CELL AND TISSUE RESEARCH

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

(2014) André Jerónimo-Santos et al.   CEREBRAL CORTEX

Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epilepsy

(2014) Zlatina Petkova et al.   EPILEPSY & BEHAVIOR

Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy

(2014) Marie Soukupová et al.   EXPERIMENTAL NEUROLOGY

The metabolic response to excitotoxicity – lessons from single-cell imaging

(2014) Niamh M. C. Connolly et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokine-Mediated Inhibition of Fibrillar Amyloid-  Peptide Degradation by Human Mononuclear Phagocytes

(2014) M. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation

(2014) N. M. C. Connolly et al.   JOURNAL OF NEUROSCIENCE

Decreased Astroglial Monocarboxylate Transporter 4 Expression in Temporal Lobe Epilepsy

(2014) Bei Liu et al.   MOLECULAR NEUROBIOLOGY

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Extrasynaptic NMDA Receptor in Excitotoxicity

(2014) Xianju Zhou et al.   NEUROSCIENTIST

Behavioral assessment of acute inhibition of system xc - in rats

(2014) Victoria Lutgen et al.   PSYCHOPHARMACOLOGY

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Cerebral glycolysis: a century of persistent misunderstanding and misconception

(2014) Avital Schurr   Frontiers in Neuroscience

The Role of Functional Neuroimaging in Pre-Surgical Epilepsy Evaluation

(2014) Francesca Pittau et al.   Frontiers in Neurology

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cortical GABAergic neurons are more severely impaired by alkalosis than acidosis

(2013) Shuyan Zhang et al.   BMC Neurology

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

(2013) Jianbin Tong et al.   EMBO JOURNAL

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

(2013) Jong Seok Bae et al.   Journal of Clinical Neurology

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Storage and Uptake of D-Serine into Astrocytic Synaptic-Like Vesicles Specify Gliotransmission

(2013) M. Martineau et al.   JOURNAL OF NEUROSCIENCE

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats

(2013) Maria Nikodemova et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Excitation BolsTORs Motor Neurons in ALS Mice

(2013) Mark P. Mattson   NEURON

The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impairments

(2013) Karina D. Thielsen et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?

(2013) Margarida V. Caldeira et al.   PROGRESS IN NEUROBIOLOGY

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Multifunctional role of astrocytes as gatekeepers of neuronal energy supply

(2013) Jillian L. Stobart et al.   Frontiers in Cellular Neuroscience

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

Early interneuron dysfunction in ALS: Insights from a mutantsod1zebrafish model

(2012) Alexander McGown et al.   ANNALS OF NEUROLOGY

Non-Cell Autonomous Influence of the Astrocyte System xc− on Hypoglycaemic Neuronal Cell Death

(2012) Nicole A Jackman et al.   ASN Neuro

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis

(2012) Darrin J. Lee et al.   EXPERIMENTAL NEUROLOGY

Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

(2012) S. Kovac et al.   JOURNAL OF CELL SCIENCE

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

(2012) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

(2012) K. Ryan et al.   JOURNAL OF NEUROSCIENCE

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis

(2012) Francesco Giribaldi et al.   NEUROPHARMACOLOGY

Energy depletion in seizures: Anaplerosis as a strategy for future therapies

(2012) Stjepana Kovac et al.   NEUROPHARMACOLOGY

Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

(2012) A. Das et al.   NEUROSCIENCE

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

(2012) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain

(2012) Amanda Wright et al.   Frontiers in Molecular Neuroscience

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Regulation of xCT expression and system $$ x_{\text{c}}^{ - } $$ function in neuronal cells

(2011) Jan Lewerenz et al.   AMINO ACIDS

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes

(2011) L.H. Bergersen et al.   CEREBRAL CORTEX

Aβ Oligomers Induce Glutamate Release from Hippocampal Neurons

(2011) J. Brito-Moreira et al.   Current Alzheimer Research

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

(2011) C. X. Bittner et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

(2011) Markel Olabarria et al.   Molecular Neurodegeneration

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Disruption of the nNOS–PSD-95 complex is neuroprotective in models of cerebral ischemia

(2011) Nick Jones   Nature Reviews Neurology

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by ExtrasynapticN-Methyl-d-aspartate Receptors

(2010) Oliver Dick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

(2010) Ling-Hui Zeng et al.   NEUROBIOLOGY OF DISEASE

Brain Energy Metabolism During Experimental Neonatal Seizures

(2010) Claude G. Wasterlain et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

(2010) Andrezza Sossai Rodrigues Carvalho et al.   NEUROCHEMISTRY INTERNATIONAL

The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25–35 into the temporal cortex

(2010) Alfonso Diaz et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

2009 Alzheimer's disease facts and figures

(2009)   Alzheimers & Dementia

Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy

(2009) SINAN SARAC et al.   APMIS

Astrocyte dysfunction in epilepsy

(2009) Gerald Seifert et al.   BRAIN RESEARCH REVIEWS

Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosis

(2009) M. Witgert et al.   EUROPEAN JOURNAL OF NEUROLOGY

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

(2009) P. Weisova et al.   JOURNAL OF NEUROSCIENCE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Effects of short interval intracortical inhibition and intracortical facilitation on short interval intracortical facilitation in human primary motor cortex

(2009) Aparna Wagle-Shukla et al.   JOURNAL OF PHYSIOLOGY-LONDON

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Effects of chronic mild stress on the oxidative parameters in the rat brain

(2009) Giancarlo Lucca et al.   NEUROCHEMISTRY INTERNATIONAL

The amyloid-β25–35 injection into the CA1 region of the neonatal rat hippocampus impairs the long-term memory because of an increase of nitric oxide

(2009) Alfonso Díaz et al.   NEUROSCIENCE LETTERS

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Focal degeneration of astrocytes in amyotrophic lateral sclerosis

(2008) D Rossi et al.   CELL DEATH AND DIFFERENTIATION

Voronoi-based spatial analysis reveals selective interneuron changes in the cortex of FALS mice

(2008) Diego Minciacchi et al.   EXPERIMENTAL NEUROLOGY

Differential involvement of TNFα in hypoxic suppression of astrocyte glutamate transporters

(2008) Hannah E. Boycott et al.   GLIA

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

NMDA receptor activity regulates transcription of antioxidant pathways

(2008) Stuart A Lipton   NATURE NEUROSCIENCE

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

(2008) Stuart G. Jarrett et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

Kainate receptors in epilepsy and excitotoxicity

(2008) P. Vincent et al.   NEUROSCIENCE

Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

(2008) F. Ferraguti et al.   PHARMACOLOGICAL REVIEWS

Neuronuclear Assessment of Patients With Epilepsy

(2008) Karolien Goffin et al.   SEMINARS IN NUCLEAR MEDICINE

Focal reduction of neuronal glutamate transporters in human neocortical epilepsy

(2007) Sanjay N. Rakhade et al.   EPILEPSIA

Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester

(2007) Bala T.S. Susarla et al.   NEUROCHEMISTRY INTERNATIONAL

Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway

(2007) P.J. Mulholland et al.   NEUROSCIENCE

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Taurine-Induced Attenuation of MPP+ Neurotoxicity In Vitro

(2003) Muriel B. O'Byrne et al.   JOURNAL OF NEUROCHEMISTRY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY