Network-wide dysregulation of calcium homeostasis in Alzheimer’s disease

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

(2013) Diana M. Sama et al.   AGEING RESEARCH REVIEWS

Ca 2+ spiking activity caused by the activation of store-operated Ca 2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation

(2013) Masayuki Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microglial calcium signaling in the adult, aged and diseased brain

(2013) Bianca Brawek et al.   CELL CALCIUM

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease

(2013) Elena Popugaeva et al.   Frontiers in Molecular Neuroscience

High-resolution in vivo imaging of microglia using a versatile nongenetically encoded marker

(2012) Bernd Schwendele et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

Spontaneous Calcium Waves in Bergman Glia Increase with Age and Hypoxia and may Reduce Tissue Oxygen

(2012) Claus Mathiesen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia

(2012) A. Torres et al.   Science Signaling

TNFα in synaptic function: switching gears

(2012) Mirko Santello et al.   TRENDS IN NEUROSCIENCES

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes

(2012) Cendra Agulhon et al.   Frontiers in Pharmacology

Transmitter- and hormone-activated Ca2+ responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca2+ sensor

(2011) Stefanie Seifert et al.   CELL CALCIUM

Cytokines and brain excitability

(2011) Michael A. Galic et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+signaling

(2011) Marioly Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Recent advances in (patho)physiology of astroglia

(2010) Alexei Verkhratsky et al.   ACTA PHARMACOLOGICA SINICA

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo

(2010) Gerhard Eichhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ATP in neuron–glia bidirectional signalling

(2010) Claudia Verderio et al.   BRAIN RESEARCH REVIEWS

Astrocytes are GABAergic cells that modulate microglial activity

(2010) Moonhee Lee et al.   GLIA

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition

(2009) Giulio Taglialatela et al.   BEHAVIOURAL BRAIN RESEARCH

The cortical innate immune response increases local neuronal excitability leading to seizures

(2009) K. M. Rodgers et al.   BRAIN

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Astrocytes going live: advances and challenges

(2009) Axel Nimmerjahn   JOURNAL OF PHYSIOLOGY-LONDON

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES