Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program

(2016) Idil Çavuş et al.   ANNALS OF NEUROLOGY

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

(2016) Jacqueline A. Hubbard et al.   EXPERIMENTAL NEUROLOGY

Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice

(2016) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Glia as drivers of abnormal neuronal activity

(2016) Stefanie Robel et al.   NATURE NEUROSCIENCE

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

(2016) Sreekanth Puttachary et al.   NEUROBIOLOGY OF DISEASE

Status Epilepticus

(2016) Syndi Seinfeld et al.   Cold Spring Harbor Perspectives in Medicine

Disinhibition reduces extracellular glutamine and elevates extracellular glutamate in rat hippocampus in vivo

(2015) Keiko Kanamori   EPILEPSY RESEARCH

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia

(2015) Magdalena Zielińska et al.   JOURNAL OF NEUROCHEMISTRY

NMDA receptor binding in focal epilepsies

(2015) C J McGinnity et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-neuronal interactions in epileptogenesis

(2015) Mussie Ghezu Hadera et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial dysfunction and seizures: the neuronal energy crisis

(2015) Gábor Zsurka et al.   LANCET NEUROLOGY

Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis

(2015) Joeri Van Liefferinge et al.   NEUROSCIENCE LETTERS

Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry

(2015) Sreekanth Puttachary et al.   PLoS One

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

(2015) Melissa Barker-Haliski et al.   Cold Spring Harbor Perspectives in Medicine

Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats

(2014) W. Saskia van der Hel et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Excitatory amino acid transporter 2 downregulation correlates with thalamic neuronal death following kainic acid-induced status epilepticus in rat

(2014) Masashi Sakurai et al.   NEUROPATHOLOGY

Review: Hippocampal sclerosis in epilepsy: a neuropathology review

(2014) Maria Thom   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Trafficking of NMDA receptors during status epilepticus: Therapeutic implications

(2013) Claude G. Wasterlain et al.   EPILEPSIA

Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus

(2013) Keiko Kanamori et al.   EPILEPSY RESEARCH

Brain Mitochondrial Metabolic Dysfunction and Glutamate Level Reduction in the Pilocarpine Model of Temporal Lobe Epilepsy in Mice

(2013) Olav B Smeland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inducible Presynaptic Glutamine Transport Supports Glutamatergic Transmission at the Calyx of Held Synapse

(2013) D. Billups et al.   JOURNAL OF NEUROSCIENCE

Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus

(2013) Meredith C. Lane et al.   NEUROCHEMISTRY INTERNATIONAL

A Transient Upregulation of Glutamine Synthetase in the Dentate Gyrus Is Involved in Epileptogenesis Induced by Amygdala Kindling in the Rat

(2013) Hong-Liu Sun et al.   PLoS One

Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy

(2013) Mark William Lopes et al.   EXPERIMENTAL BRAIN RESEARCH

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy

(2012) Tore Eid et al.   EPILEPSIA

The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors

(2012) El Hassan Hamdani et al.   GLIA

Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity

(2012) Ingrid Morales et al.   GLIA

A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3

(2012) Lasse Ormel et al.   GLIA

New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment

(2012) Vincenzo Crunelli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy

(2012) Edgar L. Perez et al.   NEUROBIOLOGY OF DISEASE

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

(2012) A. Das et al.   NEUROSCIENCE

Standards for epidemiologic studies and surveillance of epilepsy

(2011) David J. Thurman et al.   EPILEPSIA

Transition to absence seizures and the role of GABAA receptors

(2011) Vincenzo Crunelli et al.   EPILEPSY RESEARCH

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats

(2011) Ismini E. Papageorgiou et al.   GLIA

Reduced Astrocytic Contribution to the Turnover of Glutamate, Glutamine, and GABA Characterizes the Latent Phase in the Kainate Model of Temporal Lobe Epilepsy

(2011) Silje Alvestad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

(2011) Angelisa Frasca et al.   NEUROBIOLOGY OF DISEASE

Roles of glutamine in neurotransmission

(2011) Jan Albrecht et al.   Neuron Glia Biology

Differential molecular regulation of glutamate in kindling resistant rats

(2010) Taku Doi et al.   BRAIN RESEARCH

Chronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brain

(2010) Keiko Kanamori et al.   BRAIN RESEARCH

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice

(2010) Mikhail Inyushin et al.   EPILEPSIA

The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis

(2010) Shang-Der Chen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Glutamine Is Required for Persistent Epileptiform Activity in the Disinhibited Neocortical Brain Slice

(2010) H. Tani et al.   JOURNAL OF NEUROSCIENCE

Decreased glutamine synthetase, increased citrulline–nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model

(2010) Mummedy Swamy et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus

(2010) D.K. Takahashi et al.   NEUROBIOLOGY OF DISEASE

mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure

(2010) John R. Ross et al.   NEUROCHEMISTRY INTERNATIONAL

Hippocampal distribution of vesicular glutamate transporter 1 in patients with temporal lobe epilepsy

(2009) W. Saskia van der Hel et al.   EPILEPSIA

Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels

(2009) Anna Rosati et al.   JOURNAL OF NEURO-ONCOLOGY

Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats

(2008) T. Eid et al.   BRAIN

Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy

(2008) Hans-J. Bidmon et al.   EPILEPSIA

Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: The importance of the “latent period” and other concepts

(2008) Robert S. Sloviter   EPILEPSIA

Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients

(2008) Idil Cavus et al.   EPILEPSIA

Beneficial Effects of Ceftriaxone Against Pentylenetetrazole-Evoked Convulsions

(2008) Ankica V. Jelenkovic et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy

(2008) Janniche Hammer et al.   GLIA

Subfield-specific Loss of Hippocampal N-acetyl Aspartate in Temporal Lobe Epilepsy

(2007) Stefan Vielhaber et al.   EPILEPSIA

Imaging of glutamate in brain slices using FRET sensors

(2007) Chris Dulla et al.   JOURNAL OF NEUROSCIENCE METHODS

Mechanisms of glutamate release from astrocytes

(2007) Erik B. Malarkey et al.   NEUROCHEMISTRY INTERNATIONAL