Microglial polarization: novel therapeutic mechanism against Alzheimer’s disease

Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway

(2018) Juan Ji et al.   AGING CELL

sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model

(2018) Seyeon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer’s disease

(2018) Mingzhe Liu et al.   BRAIN RESEARCH

Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

(2018) Yanhua Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice

(2018) Kai Yao et al.   EXPERIMENTAL GERONTOLOGY

Simvastatin alters M1/M2 polarization of murine BV2 microglia via Notch signaling

(2018) Fei Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers

(2018) Hai-Yun Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

(2018) Scott Dyck et al.   Journal of Neuroinflammation

Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ 1–42

(2018) Haifeng Zhao et al.   NEUROSCIENCE

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

(2018) Xian-Qin Luo et al.   Chinese Medicine

Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

(2018) Chuwen Li et al.   Frontiers in Molecular Neuroscience

Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis

(2018) Yike Huang et al.   Frontiers in Immunology

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells

(2017) Valerie Sackmann et al.   NEUROBIOLOGY OF AGING

FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects

(2017) Haibiao Guo et al.   NEUROPHARMACOLOGY

Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB

(2017) Young Eun Kim et al.   NEUROPHARMACOLOGY

Physical Exercise Improves Cognitive Function Together with Microglia Phenotype Modulation and Remyelination in Chronic Cerebral Hypoperfusion

(2017) Ting Jiang et al.   Frontiers in Cellular Neuroscience

Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration

(2017) Jose L. Labandeira-Garcia et al.   Frontiers in Aging Neuroscience

Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates

(2017) Feng Zhang et al.   Frontiers in Aging Neuroscience

Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis

(2016) Kai Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

(2016) Qiuying Zhao et al.   Journal of Neuroinflammation

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

(2016) M Guo et al.   MOLECULAR PSYCHIATRY

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

(2015) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effect of a novel Rho kinase inhibitor WAR–5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors

(2015) Yan-hua Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

(2015) Xiaoning Han et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson׳s disease

(2015) Shaoxia Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

TRAM1 Promotes Microglia M1 Polarization

(2015) Hanxiang Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease

(2015) Yong-fei Zhao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy

(2015) Katarzyna Popiolek-Barczyk et al.   NEURAL PLASTICITY

Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis

(2014) Chan Chen et al.   ACTA PHARMACOLOGICA SINICA

Cytokine-Mediated Inhibition of Fibrillar Amyloid-  Peptide Degradation by Human Mononuclear Phagocytes

(2014) M. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Microglia as Dynamic and Essential Components of the Amyloid Hypothesis

(2013) Sam Gandy et al.   NEURON

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

(2012) Hong-Cui Liu et al.   CELLULAR IMMUNOLOGY

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms

(2012) Juan E. Tichauer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model

(2012) Kerstin T.S. Wirz et al.   NEUROBIOLOGY OF AGING

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

(2012) K. Kawahara et al.   NEUROSCIENCE

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms

(2011) D. R. Balce et al.   BLOOD

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease

(2010) Lih-Fen Lue et al.   MOLECULAR NEUROBIOLOGY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA