Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles

(2020) Tânia Lima et al.   Scientific Reports

Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

(2020) Niels Hadrup et al.   Small

21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis

(2020) Luna Rahman et al.   Small

Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge

(2019) Nathan L Pollesch et al.   TOXICOLOGICAL SCIENCES

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

(2019) Russell S Thomas et al.   TOXICOLOGICAL SCIENCES

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

(2019) Niels Hadrup et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Adverse Outcome Pathways: Moving from a Scientific Concept to an Internationally Accepted Framework

(2019) Markus Hecker et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations

(2019) Pranita K. Kabadi et al.   Particle and Fibre Toxicology

Development and analysis of an adverse outcome pathway network for human neurotoxicity

(2019) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice

(2019) Niels Hadrup et al.   Nanotoxicology

Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice

(2019) Kenneth Klingenberg Barfod et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice

(2019) Pernille Høgh Danielsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells

(2018) Li-Yin Hung et al.   AMERICAN JOURNAL OF PATHOLOGY

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

(2018) Robim M. Rodrigues et al.   ARCHIVES OF TOXICOLOGY

Serum amyloid A3 is pro-atherogenic

(2018) Joel C. Thompson et al.   ATHEROSCLEROSIS

Aggregation State of Metal-based Nanomaterials at the Pulmonary Surfactant Film Determines Biophysical Inhibition

(2018) Yi Yang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse outcome pathway networks II: Network analytics

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathway networks I: Development and applications

(2018) Dries Knapen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers

(2018) Christian Monsé et al.   Particle and Fibre Toxicology

Taking adverse outcome pathways to the next level

(2018) Mathieu Vinken   TOXICOLOGY IN VITRO

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

(2018) Jorid Sørli   ALTEX-Alternatives to Animal Experimentation

Global Asbestos Disaster

(2018) Sugio Furuya et al.   International Journal of Environmental Research and Public Health

Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis

(2018) Jie Dong et al.   Frontiers in Immunology

Serum amyloid A – a review

(2018) George H. Sack   MOLECULAR MEDICINE

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

(2018) Marvin Martens et al.   Frontiers in Genetics

Leveraging proteomics to compare submerged versus air-liquid interface carbon nanotube exposure to a 3D lung cell model

(2018) G. Hilton et al.   TOXICOLOGY IN VITRO

Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge

(2017) Vicki Stone et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

(2017) Rory B. Conolly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

toxFlow: A Web-Based Application for Read-Across Toxicity Prediction Using Omics and Physicochemical Data

(2017) Dimitra-Danai Varsou et al.   Journal of Chemical Information and Modeling

Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells

(2017) Yusuke Hiraku et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

(2017) Jake Nikota et al.   Particle and Fibre Toxicology

Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

(2017) Xiaobo Li et al.   Particle and Fibre Toxicology

Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs

(2017) J. Dumková et al.   Particle and Fibre Toxicology

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

(2017) Erica K. Brockmeier et al.   TOXICOLOGICAL SCIENCES

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

(2017) Penny Nymark et al.   TOXICOLOGICAL SCIENCES

Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective

(2017) Katherine S. Duke et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk

(2017) Sabina Halappanavar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

(2017) Pekka Kohonen et al.   Nature Communications

Occupational exposure to vapor, gas, dust, or fumes and chronic airflow limitation, COPD, and emphysema: the Swedish CArdioPulmonary BioImage Study (SCAPIS pilot)

(2017) Kjell Toren et al.   International Journal of Chronic Obstructive Pulmonary Disease

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice

(2017) Sarah S. Poulsen et al.   PLoS One

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

(2016) Amy J. Clippinger et al.   ARCHIVES OF TOXICOLOGY

Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)

(2016) Monita Sharma et al.   ARCHIVES OF TOXICOLOGY

Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans

(2016) Eileen D. Kuempel et al.   CRITICAL REVIEWS IN TOXICOLOGY

Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

(2016) Jie Dong et al.   Particle and Fibre Toxicology

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

(2015) Simon Sebastian Raesch et al.   ACS Nano

Biophysical Influence of Airborne Carbon Nanomaterials on Natural Pulmonary Surfactant

(2015) Russell P. Valle et al.   ACS Nano

Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes

(2015) Terry Tetley et al.   International Journal of Nanomedicine

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

(2015) Natalie Burden et al.   JOURNAL OF APPLIED TOXICOLOGY

Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film

(2015) Qinglin Hu et al.   Nanoscale

Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling

(2015) Giulia Vietti et al.   Nanotoxicology

Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

(2015) Yusuke Hiraku et al.   Particle and Fibre Toxicology

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

(2015) Giulia Vietti et al.   Particle and Fibre Toxicology

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials

(2015) Jake Nikota et al.   Particle and Fibre Toxicology

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Contribution of air pollution to COPD and small airway dysfunction

(2015) Norbert Berend   RESPIROLOGY

A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor

(2015) Elina M. Rydman et al.   TOXICOLOGICAL SCIENCES

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

(2015) Andrew Williams et al.   Beilstein Journal of Nanotechnology

Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

(2015) Ran You et al.   eLife

Time-Dependent Subcellular Distribution and Effects of Carbon Nanotubes in Lungs of Mice

(2015) Carsten Købler et al.   PLoS One

Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

(2014) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Multiwall Carbon Nanotubes Directly Promote Fibroblast-Myofibroblast and Epithelial-Mesenchymal Transitions through the Activation of the TGF-β/Smad Signaling Pathway

(2014) Peng Wang et al.   Small

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway Development II: Best Practices

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Differential expression of C-Reactive protein and Serum amyloid A in different cell types in the lung tissue of chronic obstructive pulmonary disease patients

(2014) Carmen Calero et al.   BMC Pulmonary Medicine

Increasing Hydrophobicity of Nanoparticles Intensifies Lung Surfactant Film Inhibition and Particle Retention

(2014) Russell P. Valle et al.   ACS Sustainable Chemistry & Engineering

Physicochemical Properties of Nanoparticles Regulate Translocation across Pulmonary Surfactant Monolayer and Formation of Lipoprotein Corona

(2013) Guoqing Hu et al.   ACS Nano

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation

(2013) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay

(2013) Giulia Vietti et al.   Particle and Fibre Toxicology

Particle-Induced Pulmonary Acute Phase Response Correlates with Neutrophil Influx Linking Inhaled Particles and Cardiovascular Risk

(2013) Anne Thoustrup Saber et al.   PLoS One

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

(2013) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

(2012) Marsha Wills-Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Assessment of Pulmonary Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells

(2012) Anurag Mishra et al.   Journal of Nanomaterials

Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

(2012) Anja Schinwald et al.   Particle and Fibre Toxicology

A short history of the toxicology of inhaled particles

(2012) Ken Donaldson et al.   Particle and Fibre Toxicology

The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells

(2012) Fiona A Murphy et al.   Particle and Fibre Toxicology

Inhaled nanoparticles and lung cancer - what we can learn from conventional particle toxicology

(2012) K Donaldson et al.   SWISS MEDICAL WEEKLY

Hepatic and Pulmonary Toxicogenomic Profiles in Mice Intratracheally Instilled With Carbon Black Nanoparticles Reveal Pulmonary Inflammation, Acute Phase Response, and Alterations in Lipid Homeostasis

(2012) Julie A. Bourdon et al.   TOXICOLOGICAL SCIENCES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Multiwalled Carbon Nanotubes Induce a Fibrogenic Response by Stimulating Reactive Oxygen Species Production, Activating NF-κB Signaling, and Promoting Fibroblast-to-Myofibroblast Transformation

(2011) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

(2011) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

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(2011) Zhe Dong et al.   MOLECULAR MEDICINE

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Lung Damage in Mice after Inhalation of Nanofilm Spray Products: The Role of Perfluorination and Free Hydroxyl Groups

(2010) Asger W. Nørgaard et al.   TOXICOLOGICAL SCIENCES

The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond

(2010) A. D. Maynard et al.   TOXICOLOGICAL SCIENCES

Interaction of nanoparticles with the pulmonary surfactant system

(2009) Carsten Schleh et al.   INHALATION TOXICOLOGY

Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective

(2009) Deepak K. Bhalla et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Molecular and genetic changes in asbestos-related lung cancer

(2008) Penny Nymark et al.   CANCER LETTERS

Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats

(2008) Mo-Tao Zhu et al.   TOXICOLOGY

Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model

(2007) R. R. Mercer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A comparative study of mechanisms of surfactant inhibition

(2007) Lasantha Gunasekara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Metal Nanoparticle Pollutants Interfere with Pulmonary Surfactant Function In Vitro

(2007) Mandeep Singh Bakshi et al.   BIOPHYSICAL JOURNAL