Adverse Outcome Pathway Development II: Best Practices

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

In Silico Analysis of the Conservation of Human Toxicity and Endocrine Disruption Targets in Aquatic Species

(2014) Fiona M. McRobb et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality

(2014) Christine L. Russom et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

(2014) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action

(2013) Carlie A. LaLone et al.   AQUATIC TOXICOLOGY

CROSS-SPECIES CONSERVATION OF ENDOCRINE PATHWAYS: A CRITICAL ANALYSIS OF TIER 1 FISH AND RAT SCREENING ASSAYS WITH 12 MODEL CHEMICALS

(2013) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms

(2013) Francesco Regoli et al.   MARINE ENVIRONMENTAL RESEARCH

Progress and promises in toxicogenomics in aquatic toxicology: Is technical innovation driving scientific innovation?

(2011) Karl Fent et al.   AQUATIC TOXICOLOGY

Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology

(2011) Johannes A. H. Schwöbel et al.   CHEMICAL REVIEWS

Species extrapolation for the 21st century

(2010) Malin C. Celander et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects

(2009) Kim Boekelheide et al.   TOXICOLOGICAL SCIENCES

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

(2007) Ann-Therese Karlberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY