21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis

The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis

(2019) T Raselli et al.   Journal of Crohns & Colitis

A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis

(2018) Katy M. Roach et al.   Scientific Reports

Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis

(2018) Tyler A. Beach et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis

(2017) Yunan Chen et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis

(2017) Luna Rahman et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

(2017) Jake Nikota et al.   Particle and Fibre Toxicology

Impaired Ciliogenesis in differentiating human bronchial epithelia exposed to non-Cytotoxic doses of multi-walled carbon Nanotubes

(2017) Ryan J. Snyder et al.   Particle and Fibre Toxicology

Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective

(2017) Katherine S. Duke et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice

(2017) Sarah S. Poulsen et al.   PLoS One

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

(2017) Satoshi Noguchi et al.   Scientific Reports

Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone

(2016) Jonathan M. Ciencewicki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Immune Mechanisms in Pulmonary Fibrosis

(2016) Saeed Kolahian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes

(2016) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics analysis of mouse lung responses following exposure to titanium dioxide nanomaterials reveal their disease potential at high doses

(2016) Luna Rahman et al.   MUTAGENESIS

Critical review of the current and future challenges associated with advancedin vitrosystems towards the study of nanoparticle (secondary) genotoxicity

(2016) Stephen J. Evans et al.   MUTAGENESIS

Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity

(2016) Sarah S. Poulsen et al.   Nanotoxicology

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

(2016) A. Hess et al.   TOXICOLOGY IN VITRO

Lung Microtissue Array to Screen the Fibrogenic Potential of Carbon Nanotubes

(2016) Zhaowei Chen et al.   Scientific Reports

Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

(2015) Mainul Husain et al.   Nanotoxicology

Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating

(2015) Donna C. Davidson et al.   Particle and Fibre Toxicology

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials

(2015) Jake Nikota et al.   Particle and Fibre Toxicology

Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin

(2015) S. Knippenberg et al.   THORAX

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

(2015) Andrew Williams et al.   Beilstein Journal of Nanotechnology

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

(2014) Gerrit John-Schuster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

(2014) Sinéad Weldon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

(2014) O. Delgado et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis

(2014) T. R. Cox et al.   CLINICAL CANCER RESEARCH

Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

(2014) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells

(2014) Hongyu Zhang et al.   PROTEOMICS

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation

(2014) Ursula G. Sauer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis

(2013) Deborah E. Citrin et al.   JNCI-Journal of the National Cancer Institute

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Functional Testing of an Inhalable Nanoparticle Based Influenza Vaccine Using a Human Precision Cut Lung Slice Technique

(2013) Vanessa Neuhaus et al.   PLoS One

Transcriptomic Analysis Reveals Novel Mechanistic Insight into Murine Biological Responses to Multi-Walled Carbon Nanotubes in Lungs and Cultured Lung Epithelial Cells

(2013) Sarah Søs Poulsen et al.   PLoS One

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

(2013) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

(2013) Christian Lacks Lino Cardenas et al.   PLoS Genetics

Overexpression of Tumor Necrosis Factor-α in the Lungs Alters Immune Response, Matrix Remodeling, and Repair and Maintenance Pathways

(2012) Errol M. Thomson et al.   AMERICAN JOURNAL OF PATHOLOGY

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

(2012) Helinor Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation

(2012) Takashi Moritake et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Non-classical membrane trafficking processes galore

(2012) Christelle En Lin Chua et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Multiwalled Carbon Nanotube-Induced Gene Signatures in the Mouse Lung: Potential Predictive Value for Human Lung Cancer Risk and Prognosis

(2012) Nancy L. Guo et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Differential Transcriptomic Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non–Small Cell Lung Cancer

(2012) Arun R. Pandiri et al.   TOXICOLOGIC PATHOLOGY

Gold Nanoparticles Uptake and Cytotoxicity Assessed on Rat Liver Precision-Cut Slices

(2012) Stefania Dragoni et al.   TOXICOLOGICAL SCIENCES

Effects of inhaled nano-TiO2 aerosols showing two distinct agglomeration states on rat lungs

(2012) A. Noël et al.   TOXICOLOGY LETTERS

Identification of Candidate Genes Downstream of TLR4 Signaling after Ozone Exposure in Mice: A Role for Heat-Shock Protein 70

(2011) Alison K. Bauer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

FIZZ2/RELM-  Induction and Role in Pulmonary Fibrosis

(2011) T. Liu et al.   JOURNAL OF IMMUNOLOGY

attract: A Method for Identifying Core Pathways That Define Cellular Phenotypes

(2011) Jessica C. Mar et al.   PLoS One

Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension

(2010) Eileen Hsu et al.   ARTHRITIS AND RHEUMATISM

Interleukin 6, but Not T Helper 2 Cytokines, Promotes Lung Carcinogenesis

(2010) C. E. Ochoa et al.   Cancer Prevention Research

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation

(2010) Gillian S. Backus et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

FcγRIIb Inhibits Allergic Lung Inflammation in a Murine Model of Allergic Asthma

(2010) Nilesh Dharajiya et al.   PLoS One

The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond

(2010) A. D. Maynard et al.   TOXICOLOGICAL SCIENCES

Challenges in assessing nanomaterial toxicology: a personal perspective

(2010) Charles L. Geraci et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Stereological Estimates of Alveolar Number and Size and Capillary Length and Surface Area in Mice Lungs

(2009) Juliane Knust et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

(2009) John T. Pesce et al.   PLoS Pathogens

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS

Disease-Specific Gene Expression Profiling in Multiple Models of Lung Disease

(2007) Christina C. Lewis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE