Serum amyloid A – a review

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

(2018) Magdolna Djurec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

(2018) Kairui Mao et al.   NATURE

Maternal serum amyloid A level as a novel marker of primary unexplained recurrent early pregnancy loss

(2017) Moustafa I. Ibrahim et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Serum amyloid A1 is upregulated in human glioblastoma

(2017) Franciele Hinterholz Knebel et al.   JOURNAL OF NEURO-ONCOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

(2017) Shobini Jayaraman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants

(2017) Leena B. Mithal et al.   PLoS One

Structural requirements of glycosaminoglycans for facilitating amyloid fibril formation of human serum amyloid A

(2016) Hiroka Takase et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Heparin interactions with apoA1 and SAA in inflammation-associated HDL

(2016) Andreas Digre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum amyloid A and atherosclerosis

(2016) Godfrey S. Getz et al.   CURRENT OPINION IN LIPIDOLOGY

The cytokine-serum amyloid A-chemokine network

(2016) Mieke De Buck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks

(2016) Nicholas M. Frame et al.   FEBS LETTERS

Serum amyloid A1: Structure, function and gene polymorphism

(2016) Lei Sun et al.   GENE

The activities of amyloids from a structural perspective

(2016) Roland Riek et al.   NATURE

The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice

(2015) Stephen J. Kennel et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The acute-phase protein SAA3 is present in the preterm human colostrum and breast milk

(2015) Olatejumoye Knee et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

“A Sledgehammer Breaks Glass but Forges Steel”: Bacteria Adhesion Shapes Gut Immunity

(2015) Virginia A. Pedicord et al.   CELL

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Hepatic Serum Amyloid A1 Aggravates T Cell-mediated Hepatitis by Inducing Chemokines via Toll-like Receptor 2 in Mice

(2015) Young Rae Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophils

(2015) Lei Sun et al.   JOURNAL OF IMMUNOLOGY

Bacterial Amyloid Formation: Structural Insights into Curli Biogensis

(2015) Nani Van Gerven et al.   TRENDS IN MICROBIOLOGY

Human Serum Amyloid A3 (SAA3) Protein, Expressed as a Fusion Protein with SAA2, Binds the Oxidized Low Density Lipoprotein Receptor

(2015) Takeshi Tomita et al.   PLoS One

Effect of amino acid variations in the central region of human serum amyloid A on the amyloidogenic properties

(2014) Hiroka Takase et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2

(2014) Mingjie Chen et al.   IMMUNOBIOLOGY

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

A brief elevation of serum amyloid A is sufficient to increase atherosclerosis

(2014) Joel C. Thompson et al.   JOURNAL OF LIPID RESEARCH

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis and are targets of metastasis-inducing S100A4

(2014) M T Hansen et al.   ONCOGENE

Serum Amyloid A in the Placenta and Its Role in Trophoblast Invasion

(2014) Silvana Sandri et al.   PLoS One

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis

(2014) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AA amyloidosis-resistant CE/J mice haveSaa1andSaa2genes that encode an identical SAA isoform

(2013) Masayuki Mori et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Deficiency of Endogenous Acute Phase Serum Amyloid A Does Not Affect Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice

(2013) Maria C. De Beer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Serum Amyloid A3 Binds MD-2 To Activate p38 and NF- B Pathways in a MyD88-Dependent Manner

(2013) A. Deguchi et al.   JOURNAL OF IMMUNOLOGY

Interaction of serum amyloid A with human cystatin C-assessment of amino acid residues crucial for hCC-SAA formation (part II)

(2013) Marta Spodzieja et al.   JOURNAL OF MOLECULAR RECOGNITION

Acute-phase serum amyloid A: Perspectives on its physiological and pathological roles

(2012) Robert Kisilevsky et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

SAA does not induce cytokine production in physiological conditions

(2012) Myung-Hee Kim et al.   CYTOKINE

Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2

(2012) Saipraveen Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Dissociates Serum Amyloid A (SAA) from Acute-phase High-density Lipoprotein, Promoting SAA Aggregation

(2012) Fredrik Noborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

(2012) Lee J. Quinton et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Amyloid A Facilitates the Binding of High-Density Lipoprotein From Mice Injected With Lipopolysaccharide to Vascular Proteoglycans

(2011) Tsuyoshi Chiba et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Serum amyloid A 2.2 refolds into a octameric oligomer that slowly converts to a more stable hexamer

(2011) Yun Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

(2011) Serban Nacu et al.   BMC Medical Genomics

Serum amyloid A in atherosclerosis

(2011) Victoria L. King et al.   CURRENT OPINION IN LIPIDOLOGY

Association of Genetic Variation in Serum Amyloid-A with Cardiovascular Disease and Interactions withIL6, IL1RN, IL1.BETA. and TNF Genes in the Cardiovascular Health Study

(2011) Cara L. Carty et al.   Journal of Atherosclerosis and Thrombosis

Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase

(2011) Joanne M. Wroblewski et al.   JOURNAL OF LIPID RESEARCH

Sarcoidosis—scientific progress and clinical challenges

(2011) Edward S. Chen et al.   Nature Reviews Rheumatology

Differential affinity of serum amyloid A1 isotypes for high-density lipoprotein

(2010) Toshiyuki Yamada et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Intestinal Epithelial Serum Amyloid A Modulates Bacterial Growth In Vitro and Pro-Inflammatory Responses in Mouse Experimental Colitis

(2010) Erik RM Eckhardt et al.   BMC GASTROENTEROLOGY

Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer

(2010) S L Wood et al.   BRITISH JOURNAL OF CANCER

CD36 Is a Novel Serum Amyloid A (SAA) Receptor Mediating SAA Binding and SAA-induced Signaling in Human and Rodent Cells

(2010) Irina N. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II biomarker trial of a multimarker diagnostic for ovarian cancer

(2010) Tracey Edgell et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Serum Amyloid A in Human Ovarian Epithelial Tumors: Implication for a Role in Ovarian Tumorigenesis

(2010) Simcha Urieli-Shoval et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

Impact of serum amyloid A on high density lipoprotein composition and levels

(2010) Maria C. de Beer et al.   JOURNAL OF LIPID RESEARCH

The acute phase response inhibits reverse cholesterol transport

(2010) Kenneth R. Feingold et al.   JOURNAL OF LIPID RESEARCH

Myeloperoxidase and serum amyloid A contribute to impaired in vivo reverse cholesterol transport during the acute phase response but not group IIA secretory phospholipase A2

(2010) Wijtske Annema et al.   JOURNAL OF LIPID RESEARCH

Identification and Validation of SAA as a Potential Lung Cancer Biomarker and its Involvement in Metastatic Pathogenesis of Lung Cancer

(2010) Hye-Jin Sung et al.   JOURNAL OF PROTEOME RESEARCH

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

Prion-like aggregates: infectious agents in human disease

(2010) Gunilla T. Westermark et al.   TRENDS IN MOLECULAR MEDICINE

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A

(2010) Carola Marzi et al.   PLoS Genetics

Serum Amyloid A Regulates Granulomatous Inflammation in Sarcoidosis through Toll-like Receptor-2

(2009) Edward S. Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer

(2009) E Cocco et al.   BRITISH JOURNAL OF CANCER

Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy

(2009) Jae J. Chae et al.   BRITISH JOURNAL OF HAEMATOLOGY

Serum amyloid A

(2009) Emiliano Cocco et al.   CANCER

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Responses to Amyloids of Microbial and Host Origin Are Mediated through Toll-like Receptor 2

(2009) Çagla Tükel et al.   Cell Host & Microbe

Inflammation Impairs Reverse Cholesterol Transport In Vivo

(2009) Fiona C. McGillicuddy et al.   CIRCULATION

Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome

(2009) Claudia Paret et al.   EUROPEAN UROLOGY

Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection:in vitroand in murine models of intestinal disease

(2009) Gillian E. Gardiner et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Mechanisms of the Hepatic Acute-Phase Response during Bacterial Pneumonia

(2009) L. J. Quinton et al.   INFECTION AND IMMUNITY

Secretory Phospholipase A2, Group IIA Is a Novel Serum Amyloid A Target Gene

(2009) Christopher P. Sullivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Amyloid A As a Prognostic Marker in Melanoma Identified by Proteomic Profiling

(2009) Peter Findeisen et al.   JOURNAL OF CLINICAL ONCOLOGY

Plasma Biomarkers in a Mouse Model of Preterm Labor

(2009) Qing Yang et al.   PEDIATRIC RESEARCH

Regulation of Serum Amyloid A3 (SAA3) in Mouse Colonic Epithelium and Adipose Tissue by the Intestinal Microbiota

(2009) Christopher S. Reigstad et al.   PLoS One

Serum Amyloid A, but Not C-Reactive Protein, Stimulates Vascular Proteoglycan Synthesis in a Pro-Atherogenic Manner

(2008) Patricia G. Wilson et al.   AMERICAN JOURNAL OF PATHOLOGY

Is serum amyloid A an endogenous TLR4 agonist?

(2008) Silvana Sandri et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SAA, HDL biogenesis, and inflammation

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis

(2008) J. C. H. van der Hilst et al.   RHEUMATOLOGY

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2007) Steven Bozinovski et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines

(2007) Alenka Kovacevic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY