Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Prioritizing Chemicals and Data Requirements for Screening-Level Exposure and Risk Assessment

(2012) Jon A. Arnot et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Providing the Missing Link: the Exposure Science Ontology ExO

(2012) Carolyn J. Mattingly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement

(2012) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Use of pooled samples from the national health and nutrition examination survey

(2012) Samuel P. Caudill   STATISTICS IN MEDICINE

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring

(2012) Youngja H. Park et al.   TOXICOLOGY

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Consideration of dosimetry in evaluation of ToxCast™ data

(2011) Lesa L. Aylward et al.   JOURNAL OF APPLIED TOXICOLOGY

Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

(2011)   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

(2011) Karen Blackburn et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

QSARs for PBPK modelling of environmental contaminants

(2011) T. Peyret et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

The exposure data landscape for manufactured chemicals

(2011) Peter P. Egeghy et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

A practical approach to detect unique metabolic patterns for personalized medicine

(2010) Jennifer M. Johnson et al.   ANALYST

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

PubChem as a public resource for drug discovery

(2010) Qingliang Li et al.   DRUG DISCOVERY TODAY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Enhanced metabolite identification with MSE and a semi-automated software for structural elucidation

(2010) Britta Bonn et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

(2010) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals

(2010) Thomas Peyret et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB

(2009) Thomas B. Knudsen et al.   REPRODUCTIVE TOXICOLOGY

Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database

(2009) Matthew T. Martin et al.   TOXICOLOGICAL SCIENCES

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

The Toxicity Data Landscape for Environmental Chemicals

(2008) Richard Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

(2008) Matthew T. Martin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Characterizing populations of individuals using pooled samples

(2008) Samuel P Caudill   Journal of Exposure Science and Environmental Epidemiology