Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)

A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles

(2016) Barbara Rothen-Rutishauser   ALTEX-Alternatives to Animal Experimentation

Nanomaterial Categorization for Assessing Risk Potential To Facilitate Regulatory Decision-Making

(2015) Hilary Godwin et al.   ACS Nano

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Repeated exposure to carbon nanotube-based aerosols does not affect the functional properties of a 3D human epithelial airway model

(2015) Savvina Chortarea et al.   Nanotoxicology

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

(2015) Giulia Vietti et al.   Particle and Fibre Toxicology

Multi-walled carbon nanotube-induced gene expression in vitro : Concordance with in vivo studies

(2015) Brandi N. Snyder-Talkington et al.   TOXICOLOGY

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Influence of dispersive agent on nanomaterial agglomeration and implications for biological effects in vivo or in vitro

(2015) Ursula G. Sauer et al.   TOXICOLOGY IN VITRO

Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung

(2014) D. van Berlo et al.   ARCHIVES OF TOXICOLOGY

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

(2014) Amruta Manke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model

(2014) Jennifer D. Sisler et al.   Nanotoxicology

Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats

(2014) Tatsuya Kasai et al.   Nanotoxicology

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

(2014) Linda M Sargent et al.   Particle and Fibre Toxicology

Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo

(2014) Alexia J. Taylor et al.   PLoS One

Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway

(2014) Tian Chen et al.   TOXICOLOGY LETTERS

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

(2014) Fabian Herzog et al.   Beilstein Journal of Nanotechnology

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Pulmonary toxicity of carbon nanotubes and asbestos — Similarities and differences

(2013) Ken Donaldson et al.   ADVANCED DRUG DELIVERY REVIEWS

Breaking theIn VitroAlveolar Type II Cell Proliferation Barrier while Retaining Ion Transport Properties

(2013) Peter F. Bove et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Iron Impurities in the Toxic Effects Exerted by Short Multiwalled Carbon Nanotubes (MWCNT) in Murine Alveolar Macrophages

(2013) E. Aldieri et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts

(2013) M I Suwara et al.   Mucosal Immunology

Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells

(2013) Brandi N Snyder-Talkington et al.   Particle and Fibre Toxicology

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology

(2013) Aaron Erdely et al.   Particle and Fibre Toxicology

Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay

(2013) Giulia Vietti et al.   Particle and Fibre Toxicology

An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung

(2013) Sebastian G Klein et al.   Particle and Fibre Toxicology

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

(2013) Fabian Herzog et al.   Particle and Fibre Toxicology

Transcriptomic Analysis Reveals Novel Mechanistic Insight into Murine Biological Responses to Multi-Walled Carbon Nanotubes in Lungs and Cultured Lung Epithelial Cells

(2013) Sarah Søs Poulsen et al.   PLoS One

Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway

(2013) Peng Wang et al.   Small

A Comparative Study of Different In Vitro Lung Cell Culture Systems to Assess the Most Beneficial Tool for Screening the Potential Adverse Effects of Carbon Nanotubes

(2013) Martin J. D. Clift et al.   TOXICOLOGICAL SCIENCES

A triple cell co-culture model of the air–blood barrier reconstructed from primary human cells

(2013) George Jackson et al.   TOXICOLOGY LETTERS

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies

(2012) Christoph L. Klein et al.   ARCHIVES OF TOXICOLOGY

NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination

(2012) Raymond F. Hamilton et al.   INHALATION TOXICOLOGY

Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

(2012) Kim Jantzen et al.   MUTAGENESIS

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

Pulmonary toxicity and fibrogenic response of carbon nanotubes

(2012) Amruta Manke et al.   TOXICOLOGY MECHANISMS AND METHODS

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa

(2011) Anh Thu Nguyen Hoang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Thickness of Multiwalled Carbon Nanotubes Affects Their Lung Toxicity

(2011) Ivana Fenoglio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung—A dialog between aerosol science and biology

(2011) Hanns-Rudolf Paur et al.   JOURNAL OF AEROSOL SCIENCE

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Resolving the Scar of Pulmonary Fibrosis

(2011) Gregory P. Downey   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo

(2010) Barbara Rothen-Rutishauser et al.   Nanotoxicology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Quantitative Evaluation of Cellular Uptake and Trafficking of Plain and Polyethylene Glycol-Coated Gold Nanoparticles

(2010) Christina Brandenberger et al.   Small

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An open-access microfluidic model for lung-specific functional studies at an air-liquid interface

(2009) Divya D. Nalayanda et al.   BIOMEDICAL MICRODEVICES

Engineering an artificial alveolar-capillary membrane: a novel continuously perfused model within microchannels

(2009) Divya D. Nalayanda et al.   JOURNAL OF PEDIATRIC SURGERY

Inhaled carbon nanotubes reach the subpleural tissue in mice

(2009) Jessica P. Ryman-Rasmussen et al.   Nature Nanotechnology

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes®) relative to α-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGY

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Proteomics-based safety evaluation of multi-walled carbon nanotubes

(2009) Hisao Haniu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

(2009) C. Brandenberger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake

(2008) Sarah J. Kemp et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10

(2008) E. Alfaro-Moreno et al.   EUROPEAN RESPIRATORY JOURNAL

In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter

(2008) Barbara Rothen-Rutishauser et al.   Expert Opinion on Drug Metabolism & Toxicology

Monitoring Multiwalled Carbon Nanotube Exposure in Carbon Nanotube Research Facility

(2008) Jeong Hee Han et al.   INHALATION TOXICOLOGY

Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube

(2008) Atsuya Takagi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY