Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective

A cross-sectional study of changes in markers of immunological effects and lung health due to exposure to multi-walled carbon nanotubes

(2017) Jelle Vlaanderen et al.   Nanotoxicology

STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

(2017) Katherine S. Duke et al.   Particle and Fibre Toxicology

Multiwalled Carbon Nanotube Functionalization with High Molecular Weight Hyaluronan Significantly Reduces Pulmonary Injury

(2016) Salik Hussain et al.   ACS Nano

STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation

(2016) Mesias Pedroza et al.   FASEB JOURNAL

Nanographene Oxide Functionalization with Organic and Hybrid Organic–Inorganic Polymers by Molecular Layer Deposition

(2016) Aneeta Jaggernauth et al.   Journal of Physical Chemistry C

Biological interactions of carbon-based nanomaterials: From coronation to degradation

(2016) Kunal Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

TIMP1 promotes multi-walled carbon nanotube-induced lung fibrosis by stimulating fibroblast activation and proliferation

(2016) Jie Dong et al.   Nanotoxicology

Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

(2016) Jie Dong et al.   Particle and Fibre Toxicology

Fibrosis biomarkers in workers exposed to MWCNTs

(2016) Liliya M. Fatkhutdinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resurgence of Progressive Massive Fibrosis in Coal Miners — Eastern Kentucky, 2016

(2016) David J. Blackley et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis

(2016) Megan M. Cartwright et al.   Redox Biology

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

(2015) Anurag Mishra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Signal Transducer and Activator of Transcription 1 in Murine Allergen–Induced Airway Remodeling and Exacerbation by Carbon Nanotubes

(2015) Elizabeth A. Thompson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Monitoring of TGF-β 1-Induced Human Lung Adenocarcinoma A549 Cells Epithelial-Mesenchymal Transformation Process by Measuring Cell Adhesion Force with a Microfluidic Device

(2015) Yuan Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145

(2015) Hua-Yu Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin Treatment Suppresses CCR7 Expression and the Differentiation and Migration of Human Circulating Fibrocytes

(2015) Xu-yan Fu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations

(2015) Hiroaki Arakawa et al.   EUROPEAN RADIOLOGY

Long-term retention of pristine multi-walled carbon nanotubes in rat lungs after intratracheal instillation

(2015) Naohide Shinohara et al.   JOURNAL OF APPLIED TOXICOLOGY

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2

(2015) Jie Dong et al.   Nanotoxicology

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway

(2015) Manuela Polimeni et al.   Particle and Fibre Toxicology

Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure

(2015) Erinn C. Dandley et al.   Particle and Fibre Toxicology

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

(2015) Giulia Vietti et al.   Particle and Fibre Toxicology

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling

(2015) Gani Oruqaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS

(2015) Gina M. Hilton et al.   TOXICOLOGY

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1

(2015) Kelly A. Shipkowski et al.   PLoS One

Instillation versus Inhalation of Multiwalled Carbon Nanotubes: Exposure-Related Health Effects, Clearance, and the Role of Particle Characteristics

(2014) Rona M. Silva et al.   ACS Nano

Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis

(2014) Yoshinori Aono et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

(2014) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

Akt2 Mediates TGF-�1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3�/Snail Signaling Pathway in Renal Tubular Epithelial Cells

(2014) Aiping Lan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Myeloperoxidase gene polymorphism predicts fibrosis severity in women with hepatitis C

(2014) Rodrigo Feliciano do Carmo et al.   HUMAN IMMUNOLOGY

Sneezing and Allergic Dermatitis were Increased in Engineered Nanomaterial Handling Workers

(2014) Hui-Yi LIAO et al.   INDUSTRIAL HEALTH

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

(2014) Amruta Manke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiwalled carbon nanotubes induce altered morphology and loss of barrier function in human bronchial epithelium at noncytotoxic doses

(2014) Ryan J Snyder et al.   International Journal of Nanomedicine

Health surveillance study of workers who manufacture multi-walled carbon nanotubes

(2014) Jong Seong Lee et al.   Nanotoxicology

Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammationin vivo

(2014) Forrest Jessop et al.   Nanotoxicology

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

Nickel Nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet)

(2014) Ellen E Glista-Baker et al.   Particle and Fibre Toxicology

Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo

(2014) Alexia J. Taylor et al.   PLoS One

Multiwall Carbon Nanotubes Directly Promote Fibroblast-Myofibroblast and Epithelial-Mesenchymal Transitions through the Activation of the TGF-β/Smad Signaling Pathway

(2014) Peng Wang et al.   Small

Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway

(2014) Tian Chen et al.   TOXICOLOGY LETTERS

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Carbon-Based Nanomaterials: Multifunctional Materials for Biomedical Engineering

(2013) Chaenyung Cha et al.   ACS Nano

Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo

(2013) Gregg P. Kotchey et al.   ADVANCED DRUG DELIVERY REVIEWS

Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

(2013) Tian Xia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

(2013) James C. Bonner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V2O5)

(2013) Dianne M. Walters et al.   FASEB JOURNAL

Carbon Nanotube-Induced Pulmonary Granulomatous Disease: Twist1 and Alveolar Macrophage M1 Activation

(2013) Barbara Barna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in rats

(2013) Åsa Gustafsson et al.   JOURNAL OF APPLIED TOXICOLOGY

Six-month follow-up study of health markers of nanomaterials among workers handling engineered nanomaterials

(2013) Hui-Yi Liao et al.   Nanotoxicology

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay

(2013) Giulia Vietti et al.   Particle and Fibre Toxicology

Extrapulmonary transport of MWCNT following inhalation exposure

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation

(2013) Isham Huizar et al.   RESPIRATORY RESEARCH

Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease

(2013) Gisela E Lindahl et al.   RESPIRATORY RESEARCH

Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway

(2013) Peng Wang et al.   Small

Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of theIn VivoandIn VitroStudies

(2013) Abderrahim Nemmar et al.   Biomed Research International

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cell Cycle Regulation by Carboxylated Multiwalled Carbon Nanotubes through p53-Independent Induction of p21 under the Control of the BMP Signaling Pathway

(2012) Yi Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination

(2012) Raymond F. Hamilton et al.   INHALATION TOXICOLOGY

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

IL-1R signalling is critical for regulation of multi-walled carbon nanotubes-induced acute lung inflammation in C57Bl/6 mice

(2012) Teri Alyn Girtsman et al.   Nanotoxicology

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells

(2012) Fiona A Murphy et al.   Particle and Fibre Toxicology

Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice

(2012) Anna A. Shvedova et al.   PLoS One

Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases

(2012) ATSUSHI FUJIWARA et al.   RESPIROLOGY

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

(2011) Fiona A. Murphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Multiwalled Carbon Nanotubes Induce a Fibrogenic Response by Stimulating Reactive Oxygen Species Production, Activating NF-κB Signaling, and Promoting Fibroblast-to-Myofibroblast Transformation

(2011) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

STAT1 mediates cellular senescence induced by angiotensin II and H2O2 in human glomerular mesangial cells

(2011) Sumin Jiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

(2011) Etienne Meunier et al.   Nanomedicine-Nanotechnology Biology and Medicine

Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis

(2011) Chih-Ching Chang et al.   Nanotoxicology

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Acute pulmonary response of mice to multi-wall carbon nanotubes

(2010) Sung Gu Han et al.   INHALATION TOXICOLOGY

Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo

(2010) Barbara Rothen-Rutishauser et al.   Nanotoxicology

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro

(2010) Tina Thurnherr et al.   TOXICOLOGY LETTERS

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Inhaled carbon nanotubes reach the subpleural tissue in mice

(2009) Jessica P. Ryman-Rasmussen et al.   Nature Nanotechnology

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months

(2009) Lan Ma-Hock et al.   TOXICOLOGICAL SCIENCES

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Asbestos-induced lung diseases: an update

(2009) David W. Kamp   Translational Research

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

(2008) A. A. Shvedova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma

(2008) Jessica P. Ryman-Rasmussen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phospho-control of TGF-β superfamily signaling

(2008) Katharine H Wrighton et al.   CELL RESEARCH

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION

Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model

(2007) R. R. Mercer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY