The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

(2017) Rory B. Conolly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Practical approaches to adverse outcome pathway development and weight-of-evidence evaluation as illustrated by ecotoxicological case studies

(2017) Kellie A. Fay et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A framework for predicting impacts on ecosystem services from (sub)organismal responses to chemicals

(2017) Valery E. Forbes et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes

(2016) Natàlia Garcia-Reyero et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Conformal Prediction Classification of a Large Data Set of Environmental Chemicals from ToxCast and Tox21 Estrogen Receptor Assays

(2016) Ulf Norinder et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of AhR-mediated toxicity pathway by emerging pollutants polychlorinated diphenyl sulfides

(2016) Junjiang Zhang et al.   CHEMOSPHERE

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

(2016) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

(2016) Justin G. Teeguarden et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Whole-Organism Transcriptomic Analysis Provides Mechanistic Insight into the Acute Toxicity of Emamectin Benzoate in Daphnia magna

(2016) You Song et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems

(2016) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Environmental surveillance and monitoring-The next frontiers for high-throughput toxicology

(2016) Anthony L. Schroeder et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Multilevel functional genomics data integration as a tool for understanding physiology: a network biology perspective

(2016) Peter K. Davidsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Metabolomics as read-across tool: A case study with phenoxy herbicides

(2016) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Editor’s Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity

(2016) Carlie A. LaLone et al.   TOXICOLOGICAL SCIENCES

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

(2016) Clemens Wittwehr et al.   TOXICOLOGICAL SCIENCES

Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure

(2016) E. Fabian et al.   TOXICOLOGY LETTERS

Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

(2016) Luigi Margiotta-Casaluci et al.   Scientific Reports

MOAtox: A comprehensive mode of action and acute aquatic toxicity database for predictive model development

(2015) M.G. Barron et al.   AQUATIC TOXICOLOGY

Moving from rats to cellular omics in regulatory toxicology: great challenge toward sustainability or “up-shit-creek without a paddle”?

(2015) Tewes Tralau et al.   ARCHIVES OF TOXICOLOGY

Impact of the omic technologies for understanding the modes of action of biological control agents against plant pathogens

(2015) Sebastien Massart et al.   BIOCONTROL

Investigation of the Verhaar scheme for predicting acute aquatic toxicity: Improving predictions obtained from Toxtree ver. 2.6

(2015) Claire M. Ellison et al.   CHEMOSPHERE

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

Differences in Activation of Aryl Hydrocarbon Receptors of White Sturgeon Relative to Lake Sturgeon Are Predicted by Identities of Key Amino Acids in the Ligand Binding Domain

(2015) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Systems Biology Approach Reveals a Calcium-Dependent Mechanism for Basal Toxicity in Daphnia magna

(2015) Philipp Antczak et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals

(2015) Julie A. Bourdon-Lacombe et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A novel transcriptomics based in vitro method to compare and predict hepatotoxicity based on mode of action

(2015) K. Nadira De Abrew et al.   TOXICOLOGY

Aligning the 3Rs with new paradigms in the safety assessment of chemicals

(2015) Natalie Burden et al.   TOXICOLOGY

Identification and expression of aryl hydrocarbon receptors (AhR1 and AhR2) provide insight in an evolutionary context regarding sensitivity of white sturgeon (Acipenser transmontanus) to dioxin-like compounds

(2014) Jon A. Doering et al.   AQUATIC TOXICOLOGY

Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

(2014) P. C. J. Schmeits et al.   ARCHIVES OF TOXICOLOGY

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Risk assessment in the 21st century: Roadmap and matrix

(2014) Michelle R. Embry et al.   CRITICAL REVIEWS IN TOXICOLOGY

A 21st century roadmap for human health risk assessment

(2014) Timothy P. Pastoor et al.   CRITICAL REVIEWS IN TOXICOLOGY

Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality

(2014) Christine L. Russom et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife

(2014) J. C. Madden et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals

(2014) T. H. Hutchinson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insight into the primary mode of action of TiO2nanoparticles onEscherichia coliin the dark

(2014) Bénédicte Sohm et al.   PROTEOMICS

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway Development II: Best Practices

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Dynamic energy budget approach to modeling mechanisms of CdSe quantum dot toxicity

(2013) Tin Klanjscek et al.   ECOTOXICOLOGY

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Integrative approaches for finding modular structure in biological networks

(2013) Koyel Mitra et al.   NATURE REVIEWS GENETICS

A Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes

(2013) J. Craig Rowlands et al.   TOXICOLOGICAL SCIENCES

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

A comparative analysis of biclustering algorithms for gene expression data

(2012) K. Eren et al.   BRIEFINGS IN BIOINFORMATICS

A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae

(2012) Intawat Nookaew et al.   NUCLEIC ACIDS RESEARCH

Cross-Species Transcriptomic Analysis of Mouse and Rat Lung Exposed to Chloroprene

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish

(2011) Fred A. Tilton et al.   AQUATIC TOXICOLOGY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Species extrapolation for the 21st century

(2010) Malin C. Celander et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Systems biology: Leading the revolution in ecotoxicology

(2010) Natàlia Garcia-Reyero et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Reverse engineering adverse outcome pathways

(2010) Edward J. Perkins et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects

(2010) Vincent J. Kramer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Genome-Wide Gene Expression Analysis in Response to Organophosphorus Pesticide Chlorpyrifos and Diazinon in C. elegans

(2010) Ana Viñuela et al.   PLoS One

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

(2010) et al.   SCIENCE

Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos

(2010) Estefania G. Moreira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals

(2010) Beate I Escher et al.   Integrated Environmental Assessment and Management

The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research

(2009) Michelle R. Embry et al.   AQUATIC TOXICOLOGY

Biologically Relevant Exposure Science for 21st Century Toxicity Testing

(2009) Elaine A. Cohen Hubal   TOXICOLOGICAL SCIENCES

Classification of chemicals according to mechanism of aquatic toxicity: An evaluation of the implementation of the Verhaar scheme in Toxtree

(2008) S.J. Enoch et al.   CHEMOSPHERE

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY